BPIA3_MOUSE
ID BPIA3_MOUSE Reviewed; 232 AA.
AC Q9D9J8;
DT 10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=BPI fold-containing family A member 3;
DE AltName: Full=Short palate, lung and nasal epithelium carcinoma-associated protein 3;
DE Flags: Precursor;
GN Name=Bpifa3; Synonyms=Splunc3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
CC {ECO:0000305}.
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DR EMBL; AK006829; BAB24760.1; -; mRNA.
DR CCDS; CCDS71163.1; -.
DR RefSeq; NP_001278008.1; NM_001291079.1.
DR RefSeq; NP_082804.1; NM_028528.3.
DR AlphaFoldDB; Q9D9J8; -.
DR SMR; Q9D9J8; -.
DR STRING; 10090.ENSMUSP00000028984; -.
DR GlyGen; Q9D9J8; 3 sites.
DR MaxQB; Q9D9J8; -.
DR PaxDb; Q9D9J8; -.
DR PRIDE; Q9D9J8; -.
DR Antibodypedia; 25527; 23 antibodies from 11 providers.
DR DNASU; 73388; -.
DR Ensembl; ENSMUST00000109746; ENSMUSP00000105368; ENSMUSG00000027482.
DR GeneID; 73388; -.
DR KEGG; mmu:73388; -.
DR UCSC; uc056zqd.1; mouse.
DR CTD; 128861; -.
DR MGI; MGI:1920638; Bpifa3.
DR VEuPathDB; HostDB:ENSMUSG00000027482; -.
DR eggNOG; ENOG502T3DV; Eukaryota.
DR GeneTree; ENSGT01020000230460; -.
DR HOGENOM; CLU_101222_0_0_1; -.
DR InParanoid; Q9D9J8; -.
DR OrthoDB; 1311318at2759; -.
DR BioGRID-ORCS; 73388; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Bpifa3; mouse.
DR PRO; PR:Q9D9J8; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9D9J8; protein.
DR Bgee; ENSMUSG00000027482; Expressed in seminiferous tubule of testis and 6 other tissues.
DR ExpressionAtlas; Q9D9J8; baseline and differential.
DR Genevisible; Q9D9J8; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR InterPro; IPR032946; Bpifa3.
DR InterPro; IPR017942; Lipid-bd_serum_glycop_N.
DR PANTHER; PTHR47736; PTHR47736; 1.
DR Pfam; PF01273; LBP_BPI_CETP; 1.
DR SUPFAM; SSF55394; SSF55394; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..232
FT /note="BPI fold-containing family A member 3"
FT /id="PRO_0000017188"
FT CARBOHYD 67
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 95
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 118
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 165..209
FT /evidence="ECO:0000250"
SQ SEQUENCE 232 AA; 25713 MW; 0D52D24A3076D5DC CRC64;
MHLLWRLLVL LLGLLALPSA LPKQPWPGLT KAHKDGRSTL ARIIAQGLLK LNAEGRIQSM
RLLDRLNVSG TVAPGMVGWL IGGMNFQQQQ EISINITNVQ LDCGGIQMAF PKEWFSANIT
LEFDIEFKLP FNSNIIKTHA CMGLTAESWL EKDEFGRREL VMGRCRMEPS SGGASMSTEE
TSPKMKHFLH NLRESLGKVI PNLVESQVCP LIGEILRQLD VKLLKGLVGA CS
