TAF11_HUMAN
ID TAF11_HUMAN Reviewed; 211 AA.
AC Q15544; B2R8R3; B4DY18; Q9UHS0;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 202.
DE RecName: Full=Transcription initiation factor TFIID subunit 11;
DE AltName: Full=TFIID subunit p30-beta;
DE AltName: Full=Transcription initiation factor TFIID 28 kDa subunit;
DE Short=TAF(II)28;
DE Short=TAFII-28;
DE Short=TAFII28;
GN Name=TAF11; Synonyms=TAF2I; ORFNames=PRO2134;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND PARTIAL PROTEIN SEQUENCE.
RX PubMed=7729427; DOI=10.1002/j.1460-2075.1995.tb07138.x;
RA Mengus G., May M., Jacq X., Staub A., Tora L., Chambon P., Davidson I.;
RT "Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three
RT subunits of the human transcription factor TFIID.";
RL EMBO J. 14:1520-1531(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=8820923; DOI=10.1248/bpb.19.122;
RA Kuzuhara T., Horikoshi M.;
RT "Isolation and characterization of a cDNA encoding a human TFIID subunit
RT containing a variety of putative structural motifs including direct
RT repeats.";
RL Biol. Pharm. Bull. 19:122-126(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Subthalamic nucleus, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P.,
RA Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y.,
RA LaBaer J.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ARG-68.
RG NIEHS SNPs program;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 50-211 (ISOFORM 1).
RC TISSUE=Fetal liver;
RA Zhang C., Yu Y., Zhang S., Wei H., Zhou G., Bi J., Zhang Y., Liu M., He F.;
RT "Functional prediction of the coding sequences of 33 new genes deduced by
RT analysis of cDNA clones from human fetal liver.";
RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic kidney;
RX PubMed=17525332; DOI=10.1126/science.1140321;
RA Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E.,
RA Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y.,
RA Gygi S.P., Elledge S.J.;
RT "ATM and ATR substrate analysis reveals extensive protein networks
RT responsive to DNA damage.";
RL Science 316:1160-1166(2007).
RN [11]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [12]
RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 113-201 IN COMPLEX WITH TAF13.
RX PubMed=9695952; DOI=10.1016/s0092-8674(00)81423-3;
RA Birck C., Poch O., Romier C., Ruff M., Mengus G., Lavigne A.C.,
RA Davidson I., Moras D.;
RT "Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by
RT atypical evolutionary conserved motifs also found in the SPT3 family.";
RL Cell 94:239-249(1998).
RN [13] {ECO:0007744|PDB:7EDX, ECO:0007744|PDB:7EG7, ECO:0007744|PDB:7EG8, ECO:0007744|PDB:7EG9, ECO:0007744|PDB:7EGA, ECO:0007744|PDB:7EGB, ECO:0007744|PDB:7EGC, ECO:0007744|PDB:7EGD, ECO:0007744|PDB:7EGE, ECO:0007744|PDB:7EGF}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.16 ANGSTROMS), FUNCTION, IDENTIFICATION
RP IN THE TFIID COMPLEX, AND SUBUNIT.
RX PubMed=33795473; DOI=10.1126/science.aba8490;
RA Chen X., Qi Y., Wu Z., Wang X., Li J., Zhao D., Hou H., Li Y., Yu Z.,
RA Liu W., Wang M., Ren Y., Li Z., Yang H., Xu Y.;
RT "Structural insights into preinitiation complex assembly on core
RT promoters.";
RL Science 372:0-0(2021).
CC -!- FUNCTION: The TFIID basal transcription factor complex plays a major
CC role in the initiation of RNA polymerase II (Pol II)-dependent
CC transcription (PubMed:33795473). TFIID recognizes and binds promoters
CC with or without a TATA box via its subunit TBP, a TATA-box-binding
CC protein, and promotes assembly of the pre-initiation complex (PIC)
CC (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated
CC factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7,
CC TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). TAF11,
CC together with TAF13 and TBP, play key roles during promoter binding by
CC the TFIID and TFIIA transcription factor complexes (PubMed:33795473).
CC {ECO:0000269|PubMed:33795473}.
CC -!- SUBUNIT: Component of the TFIID basal transcription factor complex,
CC composed of TATA-box-binding protein TBP, and a number of TBP-
CC associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5,
CC TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13
CC (PubMed:33795473). Interacts with TAF13 both in vitro and
CC intracellularly; also interacts directly with TBP (PubMed:9695952).
CC {ECO:0000269|PubMed:33795473, ECO:0000269|PubMed:9695952}.
CC -!- INTERACTION:
CC Q15544; Q92624: APPBP2; NbExp=6; IntAct=EBI-1027005, EBI-743771;
CC Q15544; Q15543: TAF13; NbExp=2; IntAct=EBI-1027005, EBI-1026992;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q15544-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q15544-2; Sequence=VSP_044936;
CC -!- DOMAIN: TBP and TAFII18 bind to distinct domains of TAFII28.
CC -!- SIMILARITY: Belongs to the TAF11 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF22038.1; Type=Frameshift; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC URL="http://egp.gs.washington.edu/data/taf11/";
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DR EMBL; X83928; CAA58780.1; -; mRNA.
DR EMBL; D63705; BAA23620.1; -; mRNA.
DR EMBL; AK302226; BAG63580.1; -; mRNA.
DR EMBL; AK313475; BAG36260.1; -; mRNA.
DR EMBL; CR542068; CAG46865.1; -; mRNA.
DR EMBL; BT019404; AAV38211.1; -; mRNA.
DR EMBL; BT019405; AAV38212.1; -; mRNA.
DR EMBL; AY217767; AAO25652.1; -; Genomic_DNA.
DR EMBL; AL033520; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC021972; AAH21972.1; -; mRNA.
DR EMBL; AF118094; AAF22038.1; ALT_SEQ; mRNA.
DR CCDS; CCDS4797.1; -. [Q15544-1]
DR CCDS; CCDS59014.1; -. [Q15544-2]
DR PIR; JC4540; JC4540.
DR RefSeq; NP_001257417.1; NM_001270488.1. [Q15544-2]
DR RefSeq; NP_005634.1; NM_005643.3. [Q15544-1]
DR PDB; 1BH8; X-ray; 3.00 A; B=113-201.
DR PDB; 1BH9; X-ray; 2.60 A; B=113-201.
DR PDB; 6MZD; EM; 9.80 A; P=1-211.
DR PDB; 6MZL; EM; 23.00 A; P=1-211.
DR PDB; 7EDX; EM; 4.50 A; k=1-211.
DR PDB; 7EG7; EM; 6.20 A; k=1-211.
DR PDB; 7EG8; EM; 7.40 A; k=1-211.
DR PDB; 7EG9; EM; 3.70 A; k=1-211.
DR PDB; 7EGA; EM; 4.10 A; k=1-211.
DR PDB; 7EGB; EM; 3.30 A; k=1-211.
DR PDB; 7EGC; EM; 3.90 A; k=1-211.
DR PDB; 7EGD; EM; 6.75 A; k=1-211.
DR PDB; 7EGE; EM; 9.00 A; k=1-211.
DR PDB; 7EGF; EM; 3.16 A; k=1-211.
DR PDB; 7EGI; EM; 9.82 A; k=1-211.
DR PDB; 7EGJ; EM; 8.64 A; k=1-211.
DR PDB; 7ENA; EM; 4.07 A; Dk=1-211.
DR PDB; 7ENC; EM; 4.13 A; Dk=1-211.
DR PDBsum; 1BH8; -.
DR PDBsum; 1BH9; -.
DR PDBsum; 6MZD; -.
DR PDBsum; 6MZL; -.
DR PDBsum; 7EDX; -.
DR PDBsum; 7EG7; -.
DR PDBsum; 7EG8; -.
DR PDBsum; 7EG9; -.
DR PDBsum; 7EGA; -.
DR PDBsum; 7EGB; -.
DR PDBsum; 7EGC; -.
DR PDBsum; 7EGD; -.
DR PDBsum; 7EGE; -.
DR PDBsum; 7EGF; -.
DR PDBsum; 7EGI; -.
DR PDBsum; 7EGJ; -.
DR PDBsum; 7ENA; -.
DR PDBsum; 7ENC; -.
DR AlphaFoldDB; Q15544; -.
DR SMR; Q15544; -.
DR BioGRID; 112745; 54.
DR ComplexPortal; CPX-915; General transcription factor complex TFIID.
DR ComplexPortal; CPX-930; General transcription factor complex TFIID, TAF4B variant.
DR CORUM; Q15544; -.
DR DIP; DIP-495N; -.
DR IntAct; Q15544; 20.
DR STRING; 9606.ENSP00000354633; -.
DR BindingDB; Q15544; -.
DR ChEMBL; CHEMBL4523300; -.
DR iPTMnet; Q15544; -.
DR PhosphoSitePlus; Q15544; -.
DR BioMuta; TAF11; -.
DR DMDM; 3024707; -.
DR EPD; Q15544; -.
DR jPOST; Q15544; -.
DR MassIVE; Q15544; -.
DR MaxQB; Q15544; -.
DR PaxDb; Q15544; -.
DR PeptideAtlas; Q15544; -.
DR PRIDE; Q15544; -.
DR ProteomicsDB; 5489; -.
DR ProteomicsDB; 60626; -. [Q15544-1]
DR Antibodypedia; 15108; 255 antibodies from 25 providers.
DR DNASU; 6882; -.
DR Ensembl; ENST00000361288.9; ENSP00000354633.4; ENSG00000064995.19. [Q15544-1]
DR Ensembl; ENST00000420584.3; ENSP00000408121.2; ENSG00000064995.19. [Q15544-2]
DR GeneID; 6882; -.
DR KEGG; hsa:6882; -.
DR MANE-Select; ENST00000361288.9; ENSP00000354633.4; NM_005643.4; NP_005634.1.
DR UCSC; uc003ojw.3; human. [Q15544-1]
DR CTD; 6882; -.
DR DisGeNET; 6882; -.
DR GeneCards; TAF11; -.
DR HGNC; HGNC:11544; TAF11.
DR HPA; ENSG00000064995; Low tissue specificity.
DR MIM; 600772; gene.
DR neXtProt; NX_Q15544; -.
DR OpenTargets; ENSG00000064995; -.
DR PharmGKB; PA36319; -.
DR VEuPathDB; HostDB:ENSG00000064995; -.
DR eggNOG; KOG3219; Eukaryota.
DR GeneTree; ENSGT00390000013228; -.
DR HOGENOM; CLU_088696_0_0_1; -.
DR InParanoid; Q15544; -.
DR OMA; IHECSAT; -.
DR OrthoDB; 1528461at2759; -.
DR PhylomeDB; Q15544; -.
DR TreeFam; TF315132; -.
DR PathwayCommons; Q15544; -.
DR Reactome; R-HSA-167161; HIV Transcription Initiation.
DR Reactome; R-HSA-167162; RNA Polymerase II HIV Promoter Escape.
DR Reactome; R-HSA-167172; Transcription of the HIV genome.
DR Reactome; R-HSA-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-HSA-6804756; Regulation of TP53 Activity through Phosphorylation.
DR Reactome; R-HSA-6807505; RNA polymerase II transcribes snRNA genes.
DR Reactome; R-HSA-73776; RNA Polymerase II Promoter Escape.
DR Reactome; R-HSA-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR Reactome; R-HSA-75953; RNA Polymerase II Transcription Initiation.
DR Reactome; R-HSA-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR SignaLink; Q15544; -.
DR SIGNOR; Q15544; -.
DR BioGRID-ORCS; 6882; 58 hits in 1088 CRISPR screens.
DR ChiTaRS; TAF11; human.
DR EvolutionaryTrace; Q15544; -.
DR GeneWiki; TAF11; -.
DR GenomeRNAi; 6882; -.
DR Pharos; Q15544; Tchem.
DR PRO; PR:Q15544; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q15544; protein.
DR Bgee; ENSG00000064995; Expressed in amniotic fluid and 208 other tissues.
DR ExpressionAtlas; Q15544; baseline and differential.
DR Genevisible; Q15544; HS.
DR GO; GO:0005794; C:Golgi apparatus; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; EXP:ComplexPortal.
DR GO; GO:0005669; C:transcription factor TFIID complex; IDA:UniProtKB.
DR GO; GO:0046966; F:nuclear thyroid hormone receptor binding; IPI:UniProtKB.
DR GO; GO:0042809; F:nuclear vitamin D receptor binding; IPI:UniProtKB.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0047485; F:protein N-terminus binding; IPI:UniProtKB.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IC:ARUK-UCL.
DR GO; GO:0017025; F:TBP-class protein binding; IPI:ARUK-UCL.
DR GO; GO:0003713; F:transcription coactivator activity; IDA:UniProtKB.
DR GO; GO:0042789; P:mRNA transcription by RNA polymerase II; IDA:ComplexPortal.
DR GO; GO:0043923; P:positive regulation by host of viral transcription; IDA:UniProtKB.
DR GO; GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; IDA:ComplexPortal.
DR GO; GO:0006468; P:protein phosphorylation; IDA:ComplexPortal.
DR GO; GO:0051123; P:RNA polymerase II preinitiation complex assembly; IPI:ComplexPortal.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IC:UniProtKB.
DR GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IC:UniProtKB.
DR CDD; cd08048; TAF11; 1.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR045127; TAF11-like.
DR InterPro; IPR006809; TAFII28_dom.
DR PANTHER; PTHR13218; PTHR13218; 1.
DR Pfam; PF04719; TAFII28; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Alternative splicing; Direct protein sequencing;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..211
FT /note="Transcription initiation factor TFIID subunit 11"
FT /id="PRO_0000118902"
FT REGION 1..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT VAR_SEQ 137..211
FT /note="LIQSITGTSVSQNVVIAMSGISKVFVGEVVEEALDVCEKWGEMPPLQPKHMR
FT EAVRRLKSKGQIPNSKHKKIIFF -> HWMCVRSGEKCHHYNPNI (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044936"
FT VARIANT 68
FT /note="T -> R (in dbSNP:rs15922)"
FT /evidence="ECO:0000269|Ref.6"
FT /id="VAR_016333"
FT VARIANT 155
FT /note="S -> F (in dbSNP:rs11537996)"
FT /id="VAR_052261"
FT HELIX 115..126
FT /evidence="ECO:0007829|PDB:1BH9"
FT HELIX 131..142
FT /evidence="ECO:0007829|PDB:1BH9"
FT HELIX 148..175
FT /evidence="ECO:0007829|PDB:1BH9"
FT HELIX 184..196
FT /evidence="ECO:0007829|PDB:1BH9"
SQ SEQUENCE 211 AA; 23307 MW; 77C7BDC667D19A8F CRC64;
MDDAHESPSD KGGETGESDE TAAVPGDPGA TDTDGIPEET DGDADVDLKE AAAEEGELES
QDVSDLTTVE REDSSLLNPA AKKLKIDTKE KKEKKQKVDE DEIQKMQILV SSFSEEQLNR
YEMYRRSAFP KAAIKRLIQS ITGTSVSQNV VIAMSGISKV FVGEVVEEAL DVCEKWGEMP
PLQPKHMREA VRRLKSKGQI PNSKHKKIIF F
