TAF11_RAT
ID TAF11_RAT Reviewed; 211 AA.
AC Q5U1X0;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Transcription initiation factor TFIID subunit 11;
DE AltName: Full=TFIID subunit p30-beta;
DE AltName: Full=Transcription initiation factor TFIID 28 kDa subunit;
DE Short=TAF(II)28;
DE Short=TAFII-28;
DE Short=TAFII28;
GN Name=Taf11;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: The TFIID basal transcription factor complex plays a major
CC role in the initiation of RNA polymerase II (Pol II)-dependent
CC transcription. TFIID recognizes and binds promoters with or without a
CC TATA box via its subunit TBP, a TATA-box-binding protein, and promotes
CC assembly of the pre-initiation complex (PIC). The TFIID complex
CC consists of TBP and TBP-associated factors (TAFs), including TAF1,
CC TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and
CC TAF13. TAF11, together with TAF13 and TBP, play key roles during
CC promoter binding by the TFIID and TFIIA transcription factor complexes.
CC {ECO:0000250|UniProtKB:Q15544}.
CC -!- SUBUNIT: Component of the TFIID basal transcription factor complex,
CC composed of TATA-box-binding protein TBP, and a number of TBP-
CC associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5,
CC TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Interacts with
CC TAF13 both in vitro and intracellularly; also interacts directly with
CC TBP. {ECO:0000250|UniProtKB:Q15544}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- DOMAIN: TBP and TAFII18 bind to distinct domains of TAFII28.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TAF11 family. {ECO:0000305}.
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DR EMBL; BC086421; AAH86421.1; -; mRNA.
DR RefSeq; NP_001008351.1; NM_001008350.1.
DR RefSeq; XP_006256253.1; XM_006256191.3.
DR RefSeq; XP_006256254.1; XM_006256192.3.
DR RefSeq; XP_008771034.1; XM_008772812.2.
DR AlphaFoldDB; Q5U1X0; -.
DR SMR; Q5U1X0; -.
DR STRING; 10116.ENSRNOP00000033634; -.
DR PaxDb; Q5U1X0; -.
DR PRIDE; Q5U1X0; -.
DR Ensembl; ENSRNOT00000038195; ENSRNOP00000033634; ENSRNOG00000024601.
DR GeneID; 309638; -.
DR KEGG; rno:309638; -.
DR UCSC; RGD:1305626; rat.
DR CTD; 6882; -.
DR RGD; 1305626; Taf11.
DR eggNOG; KOG3219; Eukaryota.
DR GeneTree; ENSGT00390000013228; -.
DR HOGENOM; CLU_088696_0_0_1; -.
DR InParanoid; Q5U1X0; -.
DR OMA; IHECSAT; -.
DR OrthoDB; 1528461at2759; -.
DR PhylomeDB; Q5U1X0; -.
DR TreeFam; TF315132; -.
DR Reactome; R-RNO-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-RNO-6804756; Regulation of TP53 Activity through Phosphorylation.
DR Reactome; R-RNO-6807505; RNA polymerase II transcribes snRNA genes.
DR Reactome; R-RNO-73776; RNA Polymerase II Promoter Escape.
DR Reactome; R-RNO-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR Reactome; R-RNO-75953; RNA Polymerase II Transcription Initiation.
DR Reactome; R-RNO-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR PRO; PR:Q5U1X0; -.
DR Proteomes; UP000002494; Chromosome 20.
DR Bgee; ENSRNOG00000024601; Expressed in heart and 20 other tissues.
DR Genevisible; Q5U1X0; RN.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0005669; C:transcription factor TFIID complex; ISO:RGD.
DR GO; GO:0003677; F:DNA binding; ISO:RGD.
DR GO; GO:0046966; F:nuclear thyroid hormone receptor binding; ISO:RGD.
DR GO; GO:0042809; F:nuclear vitamin D receptor binding; ISO:RGD.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0047485; F:protein N-terminus binding; ISO:RGD.
DR GO; GO:0017025; F:TBP-class protein binding; ISO:RGD.
DR GO; GO:0003713; F:transcription coactivator activity; ISO:RGD.
DR GO; GO:0042789; P:mRNA transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0043923; P:positive regulation by host of viral transcription; ISO:RGD.
DR GO; GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; ISO:RGD.
DR GO; GO:0006468; P:protein phosphorylation; ISO:RGD.
DR GO; GO:0051123; P:RNA polymerase II preinitiation complex assembly; ISO:RGD.
DR CDD; cd08048; TAF11; 1.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR045127; TAF11-like.
DR InterPro; IPR006809; TAFII28_dom.
DR PANTHER; PTHR13218; PTHR13218; 1.
DR Pfam; PF04719; TAFII28; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
PE 1: Evidence at protein level;
KW Acetylation; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..211
FT /note="Transcription initiation factor TFIID subunit 11"
FT /id="PRO_0000118905"
FT REGION 1..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..69
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..98
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q15544"
SQ SEQUENCE 211 AA; 23306 MW; 31D50FE6FBD67BF2 CRC64;
MDNLGESPTD KAGEPGESEE TRATPGAPVS ADTEGIPEET DQVGDADSKE AAAEESELKS
QDVSDVTAAE REDPSLLTPA AKKLKLDTKD KKEKKQKVDE DEIQKMQILV SSFSEEQLNR
YEMYRRSAFP KAAIKRLIQS ITGTSVSQNV VIAMSGISKV FVGEVVEEAL DVCEKWGEMP
PLQPKHMREA VRRLKSKGQI PNSKHKKITF F
