BPIA5_MOUSE
ID BPIA5_MOUSE Reviewed; 270 AA.
AC Q9CQX3; A2ARM4; Q14BY9; Q8CIW0; Q9D6P0; Q9D794;
DT 29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=BPI fold-containing family A member 5;
DE AltName: Full=BPI fold-containing family A member Pluncl;
DE AltName: Full=Palate lung and nasal carcinoma-like protein;
DE AltName: Full=Short palate lung and nasal clone protein 5;
DE AltName: Full=Tongue plunc-like protein;
DE Short=TPL;
DE Flags: Precursor;
GN Name=Bpifa5; Synonyms=Pluncl, Splunc5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC STRAIN=129S6/SvEvTac;
RX PubMed=15028288; DOI=10.1016/j.ygeno.2003.09.015;
RA LeClair E.E., Nomellini V., Bahena M., Singleton V., Bingle L.,
RA Craven C.J., Bingle C.D.;
RT "Cloning and expression of a mouse member of the PLUNC protein family
RT exclusively expressed in tongue epithelium.";
RL Genomics 83:658-666(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in innate immunity in the oral cavity.
CC {ECO:0000269|PubMed:15028288}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in interpapillar epithelium of the
CC anterior part of the tongue. {ECO:0000269|PubMed:15028288}.
CC -!- DEVELOPMENTAL STAGE: Expressed in juvenile and adult mice from
CC postnatal day 2. {ECO:0000269|PubMed:15028288}.
CC -!- SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
CC {ECO:0000305}.
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DR EMBL; AY079050; AAL82731.1; -; Genomic_DNA.
DR EMBL; AK009329; BAB26221.1; -; mRNA.
DR EMBL; AK009441; BAB26290.1; -; mRNA.
DR EMBL; AK009531; BAB26343.1; -; mRNA.
DR EMBL; AK009562; BAB26360.1; -; mRNA.
DR EMBL; AK009580; BAB26372.1; -; mRNA.
DR EMBL; AK009629; BAB26401.1; -; mRNA.
DR EMBL; AK009695; BAB26444.1; -; mRNA.
DR EMBL; AK009803; BAB26513.1; -; mRNA.
DR EMBL; AK009835; BAB26533.1; -; mRNA.
DR EMBL; AK010012; BAB26642.1; -; mRNA.
DR EMBL; AK010051; BAB26667.1; -; mRNA.
DR EMBL; AK010115; BAB26710.1; -; mRNA.
DR EMBL; AK010145; BAB26730.1; -; mRNA.
DR EMBL; AL845461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC115526; AAI15527.1; -; mRNA.
DR EMBL; BC115527; AAI15528.1; -; mRNA.
DR CCDS; CCDS16926.1; -.
DR RefSeq; NP_080266.2; NM_025990.4.
DR AlphaFoldDB; Q9CQX3; -.
DR SMR; Q9CQX3; -.
DR STRING; 10090.ENSMUSP00000028986; -.
DR PaxDb; Q9CQX3; -.
DR PRIDE; Q9CQX3; -.
DR ProteomicsDB; 265227; -.
DR DNASU; 67135; -.
DR Ensembl; ENSMUST00000028986; ENSMUSP00000028986; ENSMUSG00000027484.
DR GeneID; 67135; -.
DR KEGG; mmu:67135; -.
DR UCSC; uc008niv.2; mouse.
DR CTD; 67135; -.
DR MGI; MGI:1914385; Bpifa5.
DR VEuPathDB; HostDB:ENSMUSG00000027484; -.
DR eggNOG; ENOG502SR58; Eukaryota.
DR GeneTree; ENSGT01020000230460; -.
DR HOGENOM; CLU_095915_0_0_1; -.
DR InParanoid; Q9CQX3; -.
DR OMA; CIYPPGS; -.
DR OrthoDB; 1275829at2759; -.
DR PhylomeDB; Q9CQX3; -.
DR TreeFam; TF337052; -.
DR BioGRID-ORCS; 67135; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q9CQX3; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9CQX3; protein.
DR Bgee; ENSMUSG00000027484; Expressed in gastrula and 6 other tissues.
DR Genevisible; Q9CQX3; MM.
DR GO; GO:0005576; C:extracellular region; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0019731; P:antibacterial humoral response; ISO:MGI.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR GO; GO:0002395; P:immune response in nasopharyngeal-associated lymphoid tissue; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; ISO:MGI.
DR GO; GO:0050891; P:multicellular organismal water homeostasis; ISO:MGI.
DR GO; GO:1900229; P:negative regulation of single-species biofilm formation in or on host organism; ISO:MGI.
DR GO; GO:0050828; P:regulation of liquid surface tension; ISO:MGI.
DR GO; GO:1902305; P:regulation of sodium ion transmembrane transport; ISO:MGI.
DR InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR InterPro; IPR017942; Lipid-bd_serum_glycop_N.
DR Pfam; PF01273; LBP_BPI_CETP; 1.
DR SUPFAM; SSF55394; SSF55394; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..270
FT /note="BPI fold-containing family A member 5"
FT /id="PRO_0000017189"
FT DISULFID 196..238
FT /evidence="ECO:0000250"
FT CONFLICT 31
FT /note="D -> Y (in Ref. 2; BAB26290)"
FT /evidence="ECO:0000305"
FT CONFLICT 156
FT /note="L -> P (in Ref. 1; AAL82731)"
FT /evidence="ECO:0000305"
FT CONFLICT 220
FT /note="S -> G (in Ref. 1; AAL82731)"
FT /evidence="ECO:0000305"
FT CONFLICT 270
FT /note="T -> A (in Ref. 1; AAL82731 and 3; AAI15527/
FT AAI15528)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 270 AA; 29175 MW; 492A16EEBAB4A677 CRC64;
MFLAGSFIVL CGLLAQSTAQ LAGLPYPLGQ DLPMSMGHCR SLHVGQTLPY YGVTPVVSTY
PSDHLDRNFR DAFRHGLLSG GILSFLEHIP LLNYVRPTGS NAGGLVGVLG KVISSIPLLN
NILDIRVTNP QLLEIGLVQS YDFHRLYVTI PLGFDLRVNT LVVGSLLELS VKLDVTAEVY
AVRDSYGRSR LVIGDCIYPP GSLRISLLNR LGPLQNLIDS LTDILTRVIP GLVQGVVCPL
VNGVLSLLDV TLAHDVADAL LRGVQFVIKT
