TAF12_ARATH
ID TAF12_ARATH Reviewed; 539 AA.
AC Q9SR71;
DT 16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Transcription initiation factor TFIID subunit 12;
DE AltName: Full=TBP-associated factor 12;
DE Short=AtTAF12;
GN Name=TAF12; Synonyms=TAFII58; OrderedLocusNames=At3g10070;
GN ORFNames=T22K18.10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION, NOMENCLATURE, AND TISSUE
RP SPECIFICITY.
RX PubMed=15527982; DOI=10.1016/j.gene.2004.08.023;
RA Lago C., Clerici E., Mizzi L., Colombo L., Kater M.M.;
RT "TBP-associated factors in Arabidopsis.";
RL Gene 342:231-241(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, AND INTERACTION WITH TAF4; TAF4B;
RP TAF8; TAF11; TAF12B; TAF13 AND TAF14.
RC STRAIN=cv. Columbia;
RX PubMed=17340043; DOI=10.1007/s11103-007-9135-1;
RA Lawit S.J., O'Grady K., Gurley W.B., Czarnecka-Verner E.;
RT "Yeast two-hybrid map of Arabidopsis TFIID.";
RL Plant Mol. Biol. 64:73-87(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: TAFs are components of the transcription factor IID (TFIID)
CC complex that is essential for mediating regulation of RNA polymerase
CC transcription. {ECO:0000250}.
CC -!- SUBUNIT: Component of the TFIID complex. TFIID is composed of TATA
CC binding protein (TBP) and a number of TBP-associated factors (TAFs)
CC whose MWs range from 14-217 kDa. Can homodimerize. Interacts with TAF4,
CC TAF4B, TAF8, TAF11, TAF12B, TAF13 and TAF14.
CC {ECO:0000269|PubMed:17340043}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, leaves and inflorescences.
CC {ECO:0000269|PubMed:15527982}.
CC -!- SIMILARITY: Belongs to the TAF12 family. {ECO:0000305}.
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DR EMBL; AY463613; AAR28015.1; -; mRNA.
DR EMBL; AF344878; AAK28289.1; -; mRNA.
DR EMBL; AC010927; AAF04417.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE74856.1; -; Genomic_DNA.
DR EMBL; AK221690; BAD95394.1; -; mRNA.
DR RefSeq; NP_566367.1; NM_111842.6.
DR AlphaFoldDB; Q9SR71; -.
DR SMR; Q9SR71; -.
DR BioGRID; 5502; 11.
DR IntAct; Q9SR71; 12.
DR STRING; 3702.AT3G10070.1; -.
DR iPTMnet; Q9SR71; -.
DR PaxDb; Q9SR71; -.
DR PRIDE; Q9SR71; -.
DR ProteomicsDB; 245283; -.
DR EnsemblPlants; AT3G10070.1; AT3G10070.1; AT3G10070.
DR GeneID; 820168; -.
DR Gramene; AT3G10070.1; AT3G10070.1; AT3G10070.
DR KEGG; ath:AT3G10070; -.
DR Araport; AT3G10070; -.
DR TAIR; locus:2100053; AT3G10070.
DR eggNOG; KOG1142; Eukaryota.
DR HOGENOM; CLU_035561_0_0_1; -.
DR InParanoid; Q9SR71; -.
DR OMA; PHSSYGH; -.
DR OrthoDB; 1227642at2759; -.
DR PhylomeDB; Q9SR71; -.
DR PRO; PR:Q9SR71; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9SR71; baseline and differential.
DR Genevisible; Q9SR71; AT.
DR GO; GO:0000124; C:SAGA complex; IEA:InterPro.
DR GO; GO:0046695; C:SLIK (SAGA-like) complex; IEA:InterPro.
DR GO; GO:0005669; C:transcription factor TFIID complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0017025; F:TBP-class protein binding; IBA:GO_Central.
DR GO; GO:0051123; P:RNA polymerase II preinitiation complex assembly; IBA:GO_Central.
DR CDD; cd07981; TAF12; 1.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR037794; TAF12.
DR InterPro; IPR003228; TFIID_TAF12_dom.
DR PANTHER; PTHR12264; PTHR12264; 1.
DR Pfam; PF03847; TFIID_20kDa; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
PE 1: Evidence at protein level;
KW Activator; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..539
FT /note="Transcription initiation factor TFIID subunit 12"
FT /id="PRO_0000424050"
FT DOMAIN 397..470
FT /note="Histone-fold"
FT REGION 1..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..70
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..299
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..373
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 539 AA; 57710 MW; 72597A2E1B57EE9B CRC64;
MDQPRQSSTA SQPPETPPQP SDSKPSTLTQ IQPTPSTNPS PSSVVSSIPS SPAPQSPSLN
PNPNPPQYTR PVTSPATQQQ QHLSQPLVRP PPQAYSRPWQ QHSSYTHFSS ASSPLLSSSS
APASSSSSLP ISGQQRGGMA IGVPASPIPS PSPTPSQHSP SAFPGSFGQQ YGGLGRGTVG
MSEATSNTSS PQVRMMQGTQ GIGMMGTLGS GSQIRPSGMT QHQQRPTQSS LRPASSTSTQ
SPVAQNFQGH SLMRPSPISS PNVQSTGASQ QSLQAINQPW LSSTPQGKPP LPPPSYRPQV
NSPSMQQRPH IPQQHISTSA ATPQPQQQQS QQQHQPQEQL QQLRSPQQPL AHPHQPTRVQ
GLVNQKVTSP VMPSQPPVAQ PGNHAKTVSA ETEPSDDRIL GKRSIHELLQ QIDPSEKLDP
EVEDILSDIA EDFVESITTF GCSLAKHRKS DILEAKDILL HVERNWNIRP PGFSSDEFKT
FRKPLTTDIH KERLAAIKKS VTATEAANAR NQFGHGTANA RGGQAKTPSN PMGSTTFNH
