TAF12_DICDI
ID TAF12_DICDI Reviewed; 627 AA.
AC Q555L9; Q8MP19; Q8T176;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2009, sequence version 2.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=Transcription initiation factor TFIID subunit 12;
GN Name=TAF12; ORFNames=DDB_0231001;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Part of the multimeric TFIID complex that plays a central
CC role in mediating promoter responses to various activators and
CC repressors. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TAF12 family. {ECO:0000305}.
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DR EMBL; AC123513; AAM44379.1; -; Genomic_DNA.
DR EMBL; AAFI02000012; EAL70241.2; -; Genomic_DNA.
DR RefSeq; XP_644047.2; XM_638955.2.
DR AlphaFoldDB; Q555L9; -.
DR SMR; Q555L9; -.
DR STRING; 44689.DDB0304680; -.
DR PaxDb; Q555L9; -.
DR EnsemblProtists; EAL70241; EAL70241; DDB_G0274697.
DR GeneID; 8619477; -.
DR KEGG; ddi:DDB_G0274697; -.
DR dictyBase; DDB_G0274697; taf12.
DR eggNOG; KOG1142; Eukaryota.
DR HOGENOM; CLU_436437_0_0_1; -.
DR InParanoid; Q555L9; -.
DR OMA; NISPRHT; -.
DR Reactome; R-DDI-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-DDI-73776; RNA Polymerase II Promoter Escape.
DR Reactome; R-DDI-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR Reactome; R-DDI-75953; RNA Polymerase II Transcription Initiation.
DR Reactome; R-DDI-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR PRO; PR:Q555L9; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0000124; C:SAGA complex; ISS:dictyBase.
DR GO; GO:0046695; C:SLIK (SAGA-like) complex; IEA:InterPro.
DR GO; GO:0005669; C:transcription factor TFIID complex; ISS:dictyBase.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0017025; F:TBP-class protein binding; IBA:GO_Central.
DR GO; GO:0006325; P:chromatin organization; ISS:dictyBase.
DR GO; GO:0051123; P:RNA polymerase II preinitiation complex assembly; IBA:GO_Central.
DR GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; ISS:dictyBase.
DR CDD; cd07981; TAF12; 1.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR037794; TAF12.
DR InterPro; IPR003228; TFIID_TAF12_dom.
DR PANTHER; PTHR12264; PTHR12264; 1.
DR Pfam; PF03847; TFIID_20kDa; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
PE 3: Inferred from homology;
KW Coiled coil; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..627
FT /note="Transcription initiation factor TFIID subunit 12"
FT /id="PRO_0000377433"
FT DOMAIN 440..511
FT /note="Histone-fold"
FT /evidence="ECO:0000305"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 91..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 246..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 368..400
FT /evidence="ECO:0000255"
FT COILED 547..622
FT /evidence="ECO:0000255"
FT COMPBIAS 246..370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..401
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 627 AA; 68718 MW; 0B83377138F2230D CRC64;
MSAPQQQHNI QQQNIQQNIQ QQQPQQNVQQ PQQVIGQPQQ QPVYKPVIQI NKTLPQQQPQ
QQIPQQQQIY KQAPQQIYNQ ISPPIQQNIN SPTIVNNTPP TPVVTTPTTT TTTTQSNYST
NRPNININPA SPISSTTIAS PVTPTVLTST PPTTITTPTT TTTTSTPTTT STTVITSGTG
QPSLGSIESS IESVLRKNNL VNTTNFSPVQ NIGTTTPPPS STVVGITSPT LTQTTSSPIT
ATSITPTITS IPTTTTTNTT SPMSIGTPSS TTPVVSSVLP TTPTTTSVTA PITTTPPSSS
VTTTTTTIPT TTTGSNNSVQ ITGTNPMVYD SRQMANNSSN ITSNPTSTIN TPTTTTTTTT
ATSNSTGTIL SKQKKEKEKE KERREREIRE KENKDQQDKD KGLNSGGGGG GGIGNNNNPN
NSNNPNNSNN PNNPNNIEPE VLGKRKLIEL LQQISPNEKM DEDAEDILSV LADDFVESTV
AFACTLAKHR NSTTLEVKDL QCHLEKNWNI RVPGFGNVEQ YKTFKKPHFP ENHKLRVAAM
KKSIALTQAS SRKQQIREFK EQQKELKEQQ QQEELKQQLQ QSKKQKLQLQ QQQLQQQQQQ
LQQQQQQQQQ QQQQQLQQQQ QSPSSKF
