ID   TAF12_XENLA             Reviewed;         164 AA.
AC   Q91858; Q5D033;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Transcription initiation factor TFIID subunit 12;
DE   AltName: Full=TFIID subunit p22;
DE   AltName: Full=Transcription initiation factor TFIID 20/15 kDa subunits;
DE            Short=TAFII-20/TAFII-15;
DE            Short=TAFII20/TAFII15;
GN   Name=taf12;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8647464; DOI=10.1016/0378-1119(95)00810-1;
RA   Hasegawa S., Choi B.-I., Horikoshi M.;
RT   "Isolation of Xenopus laevis TFIID subunit p22 reveals two distinct
RT   structural regions.";
RL   Gene 169:285-286(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The TFIID basal transcription factor complex plays a major
CC       role in the initiation of RNA polymerase II (Pol II)-dependent
CC       transcription. TFIID recognizes and binds promoters via its subunit
CC       tbp, a TATA-box-binding protein, and promotes assembly of the pre-
CC       initiation complex (PIC). The TFIID complex consists of tbp and TBP-
CC       associated factors (TAFs). {ECO:0000250|UniProtKB:Q16514}.
CC   -!- SUBUNIT: Component of the TFIID basal transcription factor complex,
CC       composed of TATA-box-binding protein tbp, and a number of TBP-
CC       associated factors (TAFs). Component of the TATA-binding protein-free
CC       TAF complex (TFTC), the PCAF histone acetylase complex and the STAGA
CC       transcription coactivator-HAT complex. {ECO:0000250|UniProtKB:Q16514}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=TAFII20;
CC         IsoId=Q91858-1; Sequence=Displayed;
CC       Name=TAFII15;
CC         IsoId=Q91858-2; Sequence=VSP_018889;
CC   -!- SIMILARITY: Belongs to the TAF12 family. {ECO:0000305}.
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DR   EMBL; D63522; BAA09789.1; -; mRNA.
DR   EMBL; BC068646; AAH68646.1; -; mRNA.
DR   PIR; JC4675; JC4675.
DR   RefSeq; NP_001081155.1; NM_001087686.1. [Q91858-1]
DR   RefSeq; XP_018100341.1; XM_018244852.1. [Q91858-1]
DR   AlphaFoldDB; Q91858; -.
DR   SMR; Q91858; -.
DR   DNASU; 394417; -.
DR   GeneID; 394417; -.
DR   KEGG; xla:394417; -.
DR   CTD; 394417; -.
DR   Xenbase; XB-GENE-943299; taf12.L.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 394417; Expressed in oocyte and 19 other tissues.
DR   GO; GO:0000124; C:SAGA complex; IEA:InterPro.
DR   GO; GO:0046695; C:SLIK (SAGA-like) complex; IEA:InterPro.
DR   GO; GO:0005669; C:transcription factor TFIID complex; IEA:InterPro.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR   CDD; cd07981; TAF12; 1.
DR   Gene3D; 1.10.20.10; -; 1.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR037794; TAF12.
DR   InterPro; IPR003228; TFIID_TAF12_dom.
DR   PANTHER; PTHR12264; PTHR12264; 1.
DR   Pfam; PF03847; TFIID_20kDa; 1.
DR   SUPFAM; SSF47113; SSF47113; 1.
PE   2: Evidence at transcript level;
KW   Alternative initiation; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..164
FT                   /note="Transcription initiation factor TFIID subunit 12"
FT                   /id="PRO_0000033582"
FT   DOMAIN          59..131
FT                   /note="Histone-fold"
FT                   /evidence="ECO:0000305"
FT   REGION          14..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..32
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..33
FT                   /note="Missing (in isoform TAFII15)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_018889"
SQ   SEQUENCE   164 AA;  18097 MW;  6594DD1CC91836B9 CRC64;
     MNQFGASALI NLSSFSSSTT PSPTSVAVKQ EPAMANSTPV GKVPVPTAGG GRASPEANQV
     LSKKKLHDLV REVDPNEQLD EDVEEMLLQI ADDFIESVVS AACQLARHRK SNTLEVKDVQ
     LHLERQWNMW IPGFGSEEIR PYKKACTTEA HKQRMALIKK TQKK