ID   BPIB1_BOVIN             Reviewed;         473 AA.
AC   Q8SPF8; Q08DT9;
DT   29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=BPI fold-containing family B member 1;
DE   AltName: Full=Long palate, lung and nasal epithelium carcinoma-associated protein 1;
DE   AltName: Full=von Ebner minor salivary gland protein;
DE            Short=VEMSGP;
DE   Flags: Precursor;
GN   Name=BPIFB1; Synonyms=LPLUNC1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Holstein-Friesian; TISSUE=Parotid gland;
RX   PubMed=12427544; DOI=10.1016/s0167-4781(02)00508-0;
RA   Wheeler T.T., Haigh B.J., McCracken J.Y., Wilkins R.J., Morris C.A.,
RA   Grigor M.R.;
RT   "The BSP30 salivary proteins from cattle, LUNX/PLUNC and von Ebner's minor
RT   salivary gland protein are members of the PSP/LBP superfamily of
RT   proteins.";
RL   Biochim. Biophys. Acta 1579:92-100(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal lung;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in innate immunity in mouth, nose and lungs.
CC       Binds bacterial lipopolysaccharide (LPS) and modulates the cellular
CC       responses to LPS (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in trachea, nasoepithelial tissue and in
CC       salivary tissue.
CC   -!- SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
CC       {ECO:0000305}.
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DR   EMBL; AF488705; AAM00906.1; -; mRNA.
DR   EMBL; BC123569; AAI23570.1; -; mRNA.
DR   RefSeq; NP_777122.1; NM_174697.2.
DR   AlphaFoldDB; Q8SPF8; -.
DR   SMR; Q8SPF8; -.
DR   STRING; 9913.ENSBTAP00000020875; -.
DR   PaxDb; Q8SPF8; -.
DR   PRIDE; Q8SPF8; -.
DR   GeneID; 282643; -.
DR   KEGG; bta:282643; -.
DR   CTD; 92747; -.
DR   eggNOG; KOG4160; Eukaryota.
DR   InParanoid; Q8SPF8; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR   GO; GO:0034144; P:negative regulation of toll-like receptor 4 signaling pathway; IBA:GO_Central.
DR   InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR   InterPro; IPR021193; Bpifb1.
DR   InterPro; IPR001124; Lipid-bd_serum_glycop_C.
DR   InterPro; IPR017942; Lipid-bd_serum_glycop_N.
DR   PANTHER; PTHR47395; PTHR47395; 1.
DR   Pfam; PF01273; LBP_BPI_CETP; 1.
DR   Pfam; PF02886; LBP_BPI_CETP_C; 1.
DR   PIRSF; PIRSF037186; PLUNC_long_form; 1.
DR   SMART; SM00328; BPI1; 1.
DR   SUPFAM; SSF55394; SSF55394; 2.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Immunity; Innate immunity;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..473
FT                   /note="BPI fold-containing family B member 1"
FT                   /id="PRO_0000017179"
FT   CARBOHYD        215
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        422
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        156..199
FT                   /evidence="ECO:0000250"
FT   CONFLICT        190
FT                   /note="P -> L (in Ref. 2; AAI23570)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        387
FT                   /note="Y -> H (in Ref. 2; AAI23570)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   473 AA;  51700 MW;  46AE5CDFEEFC6219 CRC64;
     MAYPWTFTFL CGLLAANLVG ATLSPPVVLS LSTEVIKQML AQKLKNHDVT NTLQQLPLLT
     AMEEESSRGI FGNLVKSILK HILWMKVTSA SIGQLQVQPL ANGRQLMVKA PLDVVAGFNV
     PLFKTVVELH VEVEAQAIIH VETREKDHAR LVLSECSNTG GSLRVSLLHK LSFLLKCLAD
     KVISLLTPAP PKLVKSELCP VLKAGFEDMR GELLNLTKVP MSLNSEHLKL DFISPVIDHS
     VVHLILGARL FNSEGKVTKL FNVAGDSLNL PTLNQTPFRL TVRKDVVVAI IAALIHSGKL
     TVLLDYVLPE VARQLRSSIK VIDETAAAQL GPTQIVKIMS QTTPMLILDQ GNAKVAQLIV
     LEIFATDKDS RPLFTLGIEA SSDIQFYVED GLLVFSFNEI RADRIHLMNS DIGVFNPKLL
     NNITTKILTS ILLPNENGKL RSGIPVSMVK NLGFKSISLS LTKEALVVTQ ASS