TAF13_MOUSE
ID TAF13_MOUSE Reviewed; 124 AA.
AC P61216; Q3TVE8;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2004, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Transcription initiation factor TFIID subunit 13 {ECO:0000250|UniProtKB:Q15543};
DE AltName: Full=Transcription initiation factor TFIID 18 kDa subunit {ECO:0000250|UniProtKB:Q15543};
DE Short=TAF(II)18 {ECO:0000250|UniProtKB:Q15543};
DE Short=TAFII-18 {ECO:0000250|UniProtKB:Q15543};
DE Short=TAFII18 {ECO:0000250|UniProtKB:Q15543};
GN Name=Taf13 {ECO:0000312|MGI:MGI:1913500};
GN Synonyms=Taf2k {ECO:0000250|UniProtKB:Q15543};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Pancreas, Small intestine, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: The TFIID basal transcription factor complex plays a major
CC role in the initiation of RNA polymerase II (Pol II)-dependent
CC transcription. TFIID recognizes and binds promoters via its subunit
CC TBP, a TATA-box-binding protein, and promotes assembly of the pre-
CC initiation complex (PIC). The TFIID complex consists of TBP and TBP-
CC associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5,
CC TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF13, together
CC with TAF11 and TBP, play key roles during promoter binding by the TFIID
CC and TFIIA transcription factor complexes.
CC {ECO:0000250|UniProtKB:Q15543}.
CC -!- SUBUNIT: Component of the TFIID basal transcription factor complex,
CC composed of TATA-box-binding protein TBP, and a number of TBP-
CC associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5,
CC TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Interacts with
CC TBP, and more strongly with TAF10 and TAF11.
CC {ECO:0000250|UniProtKB:Q15543}.
CC -!- INTERACTION:
CC P61216; Q99JX1: Taf11; NbExp=3; IntAct=EBI-309424, EBI-309427;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q15543}.
CC -!- DOMAIN: The binding of TAF10 and TAF11 requires distinct domains of
CC TAF13. {ECO:0000250|UniProtKB:Q15543}.
CC -!- SIMILARITY: Belongs to the TAF13 family. {ECO:0000305}.
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DR EMBL; AK007339; BAB24972.1; -; mRNA.
DR EMBL; AK076595; BAC36408.1; -; mRNA.
DR EMBL; AK160171; BAE35671.1; -; mRNA.
DR EMBL; BC021447; AAH21447.1; -; mRNA.
DR CCDS; CCDS17764.1; -.
DR RefSeq; NP_079720.1; NM_025444.2.
DR AlphaFoldDB; P61216; -.
DR SMR; P61216; -.
DR BioGRID; 221311; 4.
DR ComplexPortal; CPX-932; General transcription factor complex TFIID.
DR ComplexPortal; CPX-959; General transcription factor complex TFIID, Taf4b variant.
DR IntAct; P61216; 4.
DR MINT; P61216; -.
DR STRING; 10090.ENSMUSP00000121346; -.
DR iPTMnet; P61216; -.
DR PhosphoSitePlus; P61216; -.
DR EPD; P61216; -.
DR MaxQB; P61216; -.
DR PaxDb; P61216; -.
DR PeptideAtlas; P61216; -.
DR PRIDE; P61216; -.
DR ProteomicsDB; 259346; -.
DR Antibodypedia; 33744; 163 antibodies from 23 providers.
DR DNASU; 99730; -.
DR Ensembl; ENSMUST00000143054; ENSMUSP00000121346; ENSMUSG00000048100.
DR GeneID; 99730; -.
DR KEGG; mmu:99730; -.
DR UCSC; uc008qzh.1; mouse.
DR CTD; 6884; -.
DR MGI; MGI:1913500; Taf13.
DR VEuPathDB; HostDB:ENSMUSG00000048100; -.
DR eggNOG; KOG3901; Eukaryota.
DR GeneTree; ENSGT00390000012981; -.
DR HOGENOM; CLU_076665_4_0_1; -.
DR InParanoid; P61216; -.
DR OMA; INEMCLE; -.
DR OrthoDB; 1478135at2759; -.
DR PhylomeDB; P61216; -.
DR TreeFam; TF323609; -.
DR Reactome; R-MMU-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-MMU-6804756; Regulation of TP53 Activity through Phosphorylation.
DR Reactome; R-MMU-6807505; RNA polymerase II transcribes snRNA genes.
DR Reactome; R-MMU-73776; RNA Polymerase II Promoter Escape.
DR Reactome; R-MMU-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR Reactome; R-MMU-75953; RNA Polymerase II Transcription Initiation.
DR Reactome; R-MMU-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR BioGRID-ORCS; 99730; 27 hits in 73 CRISPR screens.
DR ChiTaRS; Taf13; mouse.
DR PRO; PR:P61216; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; P61216; protein.
DR Bgee; ENSMUSG00000048100; Expressed in animal zygote and 75 other tissues.
DR Genevisible; P61216; MM.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0005669; C:transcription factor TFIID complex; ISO:MGI.
DR GO; GO:0003677; F:DNA binding; IDA:MGI.
DR GO; GO:0008022; F:protein C-terminus binding; ISO:MGI.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0017025; F:TBP-class protein binding; ISO:MGI.
DR GO; GO:0042789; P:mRNA transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; ISO:MGI.
DR GO; GO:0006468; P:protein phosphorylation; ISO:MGI.
DR GO; GO:0051123; P:RNA polymerase II preinitiation complex assembly; ISO:MGI.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07978; TAF13; 1.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR003195; TFIID_TAF13.
DR PANTHER; PTHR11380; PTHR11380; 1.
DR Pfam; PF02269; TFIID-18kDa; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..124
FT /note="Transcription initiation factor TFIID subunit 13"
FT /id="PRO_0000118911"
FT DOMAIN 32..74
FT /note="Histone-fold"
FT /evidence="ECO:0000305"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 124 AA; 14287 MW; 98B62FF1BC8E7B77 CRC64;
MADEEEDPTF EEENEEIGGG AEGGQGKRKR LFSKELRCMM YGFGDDQNPY TESVDILEDL
VIEFITEMTH KAMSIGRQGR VQVEDIVFLI RKDPRKFARV KDLLTMNEEL KRARKAFDEA
NYGS
