TAF1A_MOUSE
ID TAF1A_MOUSE Reviewed; 453 AA.
AC P97357;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=TATA box-binding protein-associated factor RNA polymerase I subunit A;
DE AltName: Full=RNA polymerase I-specific TBP-associated factor 48 kDa;
DE Short=TAFI48;
DE AltName: Full=TATA box-binding protein-associated factor 1A;
DE Short=TBP-associated factor 1A;
DE AltName: Full=Transcription initiation factor SL1/TIF-IB subunit A;
GN Name=Taf1a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INTERACTION WITH TBP; TAF1B AND
RP TAF1C.
RX PubMed=9050847; DOI=10.1073/pnas.94.5.1733;
RA Heix J., Zomerdijk J.C.B.M., Ravanpay A., Tjian R., Grummt I.;
RT "Cloning of murine RNA polymerase I-specific TAF factors: conserved
RT interactions between the subunits of the species-specific transcription
RT initiation factor TIF-IB/SL1.";
RL Proc. Natl. Acad. Sci. U.S.A. 94:1733-1738(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the transcription factor SL1/TIF-IB complex,
CC which is involved in the assembly of the PIC (pre-initiation complex)
CC during RNA polymerase I-dependent transcription. The rate of PIC
CC formation probably is primarily dependent on the rate of association of
CC SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in
CC stabilization of nucleolar transcription factor 1/UBTF on rDNA.
CC Formation of SL1/TIF-IB excludes the association of TBP with TFIID
CC subunits (By similarity). {ECO:0000250, ECO:0000269|PubMed:9050847}.
CC -!- SUBUNIT: Component of the transcription factor SL1/TIF-IB complex,
CC composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the
CC complex interacts directly with TBP, TAF1A and TAF1B. Interaction of
CC the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the
CC transcription factor IID (TFIID) subunits. Interacts with UBFT (By
CC similarity). Interacts with CEBPA (isoform 1 and isoform 4) (By
CC similarity). {ECO:0000250|UniProtKB:Q15573}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; Y09972; CAA71091.1; -; mRNA.
DR EMBL; AK132811; BAE21371.1; -; mRNA.
DR EMBL; BC061106; AAH61106.1; -; mRNA.
DR RefSeq; NP_001264886.1; NM_001277957.1.
DR RefSeq; NP_001264887.1; NM_001277958.1.
DR RefSeq; NP_001264888.1; NM_001277959.1.
DR RefSeq; NP_067441.1; NM_021466.3.
DR AlphaFoldDB; P97357; -.
DR BioGRID; 203956; 6.
DR CORUM; P97357; -.
DR DIP; DIP-60267N; -.
DR IntAct; P97357; 2.
DR STRING; 10090.ENSMUSP00000094808; -.
DR iPTMnet; P97357; -.
DR PhosphoSitePlus; P97357; -.
DR EPD; P97357; -.
DR MaxQB; P97357; -.
DR PaxDb; P97357; -.
DR PeptideAtlas; P97357; -.
DR PRIDE; P97357; -.
DR ProteomicsDB; 254491; -.
DR Antibodypedia; 20741; 234 antibodies from 29 providers.
DR DNASU; 21339; -.
DR Ensembl; ENSMUST00000192076; ENSMUSP00000142213; ENSMUSG00000072258.
DR GeneID; 21339; -.
DR KEGG; mmu:21339; -.
DR UCSC; uc008ida.2; mouse.
DR CTD; 9015; -.
DR MGI; MGI:109578; Taf1a.
DR eggNOG; ENOG502R510; Eukaryota.
DR GeneTree; ENSGT00390000011405; -.
DR InParanoid; P97357; -.
DR OMA; EMIWRIG; -.
DR OrthoDB; 1173909at2759; -.
DR PhylomeDB; P97357; -.
DR Reactome; R-MMU-5250924; B-WICH complex positively regulates rRNA expression.
DR Reactome; R-MMU-73762; RNA Polymerase I Transcription Initiation.
DR Reactome; R-MMU-73772; RNA Polymerase I Promoter Escape.
DR Reactome; R-MMU-73863; RNA Polymerase I Transcription Termination.
DR BioGRID-ORCS; 21339; 20 hits in 52 CRISPR screens.
DR ChiTaRS; Taf1a; mouse.
DR PRO; PR:P97357; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; P97357; protein.
DR Bgee; ENSMUSG00000072258; Expressed in primary oocyte and 191 other tissues.
DR ExpressionAtlas; P97357; baseline and differential.
DR GO; GO:0015630; C:microtubule cytoskeleton; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0000120; C:RNA polymerase I transcription regulator complex; TAS:MGI.
DR GO; GO:0005668; C:RNA polymerase transcription factor SL1 complex; IPI:MGI.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006360; P:transcription by RNA polymerase I; TAS:MGI.
DR InterPro; IPR016629; RNA_pol_I_TAF1A/TAFI48_chr.
DR InterPro; IPR039495; TAF1A.
DR Pfam; PF14929; TAF1_subA; 1.
DR PIRSF; PIRSF015161; TAFI48; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..453
FT /note="TATA box-binding protein-associated factor RNA
FT polymerase I subunit A"
FT /id="PRO_0000227988"
SQ SEQUENCE 453 AA; 52718 MW; 36FAB970FBC5956F CRC64;
MMSDFGEELT KLAVAEDNPE TSVLSKTGMH FPWLHKHVEA VVTGGKKRKD FAQTTSACLS
FIQEALLKHQ WQQAAEYMHS YLQTLEDSDT DKRQAAPEII WKLGSEILFY HPKSNVETFN
SFADRMKNIG VLNYLKISLQ HALYLLHHGM LDDANRNLSK AETWRYGEKS SSQEVLINLV
QAYKGLLQYY TWTRKKMELS KLDEDDYAYA AKTRTMLSQS CKTSTNICAL VKTPGVWDPF
VKSYVEMLEF YGDQDGAREM LTNYAYDEKF PSNPNAHVYL YEFLKREKAP RAKLISVLKI
LHEIVPSHTL MLEFHTLLRK SDTEEHQKLG LSVLFEVLDF AGCNKNITAW KYLAKYLKQI
LVGSHHEWVE EEWKSRRNWW PAFHFSFFWA KSDWKADTDL ACEKAFVAGV LLGKGCKYFR
YILKQDHETL KKKIKRMKKS VKKYTIVNPG VHT
