ID   TAF1A_RAT               Reviewed;         453 AA.
AC   Q3B7U2;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=TATA box-binding protein-associated factor RNA polymerase I subunit A;
DE   AltName: Full=TATA box-binding protein-associated factor 1A;
DE            Short=TBP-associated factor 1A;
DE   AltName: Full=Transcription initiation factor SL1/TIF-IB subunit A;
GN   Name=Taf1a;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   INTERACTION WITH CEBPA.
RX   PubMed=20075868; DOI=10.1038/emboj.2009.404;
RA   Muller C., Bremer A., Schreiber S., Eichwald S., Calkhoven C.F.;
RT   "Nucleolar retention of a translational C/EBPalpha isoform stimulates rDNA
RT   transcription and cell size.";
RL   EMBO J. 29:897-909(2010).
CC   -!- FUNCTION: Component of the transcription factor SL1/TIF-IB complex,
CC       which is involved in the assembly of the PIC (pre-initiation complex)
CC       during RNA polymerase I-dependent transcription. The rate of PIC
CC       formation probably is primarily dependent on the rate of association of
CC       SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in
CC       stabilization of nucleolar transcription factor 1/UBTF on rDNA.
CC       Formation of SL1/TIF-IB excludes the association of TBP with TFIID
CC       subunits (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the transcription factor SL1/TIF-IB complex,
CC       composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the
CC       complex interacts directly with TBP, TAF1A and TAF1B. Interaction of
CC       the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the
CC       transcription factor IID (TFIID) subunits. Interacts with UBFT (By
CC       similarity). Interacts with CEBPA (isoform 1 and isoform 4)
CC       (PubMed:20075868). {ECO:0000250, ECO:0000269|PubMed:20075868}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; BC107466; AAI07467.1; -; mRNA.
DR   RefSeq; NP_001032281.1; NM_001037204.1.
DR   RefSeq; XP_017454352.1; XM_017598863.1.
DR   AlphaFoldDB; Q3B7U2; -.
DR   STRING; 10116.ENSRNOP00000062006; -.
DR   PaxDb; Q3B7U2; -.
DR   PRIDE; Q3B7U2; -.
DR   Ensembl; ENSRNOT00000087784; ENSRNOP00000068899; ENSRNOG00000061139.
DR   GeneID; 360893; -.
DR   KEGG; rno:360893; -.
DR   UCSC; RGD:1305698; rat.
DR   CTD; 9015; -.
DR   RGD; 1305698; Taf1a.
DR   eggNOG; ENOG502R510; Eukaryota.
DR   GeneTree; ENSGT00390000011405; -.
DR   InParanoid; Q3B7U2; -.
DR   OrthoDB; 1173909at2759; -.
DR   PhylomeDB; Q3B7U2; -.
DR   Reactome; R-RNO-5250924; B-WICH complex positively regulates rRNA expression.
DR   Reactome; R-RNO-73762; RNA Polymerase I Transcription Initiation.
DR   Reactome; R-RNO-73772; RNA Polymerase I Promoter Escape.
DR   Reactome; R-RNO-73863; RNA Polymerase I Transcription Termination.
DR   PRO; PR:Q3B7U2; -.
DR   Proteomes; UP000002494; Chromosome 13.
DR   GO; GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005668; C:RNA polymerase transcription factor SL1 complex; ISO:RGD.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006360; P:transcription by RNA polymerase I; IEA:InterPro.
DR   InterPro; IPR016629; RNA_pol_I_TAF1A/TAFI48_chr.
DR   InterPro; IPR039495; TAF1A.
DR   Pfam; PF14929; TAF1_subA; 1.
DR   PIRSF; PIRSF015161; TAFI48; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..453
FT                   /note="TATA box-binding protein-associated factor RNA
FT                   polymerase I subunit A"
FT                   /id="PRO_0000227989"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   453 AA;  53021 MW;  3E36DF2E2D043B36 CRC64;
     MMSDFSEELT KLAGAEDNPE TSEFSKTRMH FPWLQKHIEA VVTGGKKRKD FAQTTSACLS
     FLQEALLKHQ WCRAAEYMHS YLQTLEDSDT YRKQAAPEII WKLGSEILFY HPKSNVETFS
     SFADRMKNIG VLNYLKISLQ HALYLLHHGM LEDANRNLSE AETWRYGEKS ASQEVLIKLV
     QAYKGLLQHY SWSKKKMELS ELDEDDYAYT AKSRNMLSQS SKTSTNICTL IKTPGVWDPF
     VKSYVEMLEF YGDQDGAREL LTNYAYDEKF PSNPNAHVYL YEFLKREKAP RAKLISVLKI
     LHEIVPSHSL MLEFHTLLRK SETEEHRKLG LAVLFEVLDF SGCTKNITAW KYLAKYLKQT
     LMESHREWVE EEWKSRRNWW PAFHFSFFWA KSDWKADAEL ACEKAFVAGI LLGKGCRYFR
     YILKQDHETL KKKIKRMKKS VKKYTIVNPG VHT