BPIB1_MOUSE
ID BPIB1_MOUSE Reviewed; 474 AA.
AC Q61114; A2AJD5; Q497Q1; Q4VC32;
DT 29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 4.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=BPI fold-containing family B member 1;
DE AltName: Full=Long palate, lung and nasal epithelium carcinoma-associated protein 1;
DE Flags: Precursor;
GN Name=Bpifb1; Synonyms=Lplunc1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Swiss Webster;
RA Snead M.L., Villanueva J., Paine M.L., Lei Y.P., Zhu D.H., Lusis J.,
RA Xia Y.-R., Yang J.-N.;
RL Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=14745963; DOI=10.1002/dvdy.10450;
RA Hou J., Yashiro K., Okazaki Y., Saijoh Y., Hayashizaki Y., Hamada H.;
RT "Identification of a novel left-right asymmetrically expressed gene in the
RT mouse belonging to the BPI/PLUNC superfamily.";
RL Dev. Dyn. 229:373-379(2004).
RN [5]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=15028288; DOI=10.1016/j.ygeno.2003.09.015;
RA LeClair E.E., Nomellini V., Bahena M., Singleton V., Bingle L.,
RA Craven C.J., Bingle C.D.;
RT "Cloning and expression of a mouse member of the PLUNC protein family
RT exclusively expressed in tongue epithelium.";
RL Genomics 83:658-666(2004).
CC -!- FUNCTION: May play a role in innate immunity in mouth, nose and lungs.
CC Binds bacterial lipopolysaccharide (LPS) and modulates the cellular
CC responses to LPS. May be involved in formation of the left-right axis
CC in the node of the developing embryo. {ECO:0000269|PubMed:14745963,
CC ECO:0000269|PubMed:15028288}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:14745963}.
CC -!- TISSUE SPECIFICITY: Expressed in tongue, lung, thymus, and stomach.
CC Expressed in epithelia of palate, anterior pharynx, trachea and upper
CC bronchi. Expressed in distal tip of papillae in the anterior third of
CC the tongue and in serous cells of von Ebner glands in the posterior
CC third of the tongue. Expressed in columnar epithelium of the duodenum
CC in embryonic gut at 16.5 dpc. {ECO:0000269|PubMed:14745963,
CC ECO:0000269|PubMed:15028288}.
CC -!- DEVELOPMENTAL STAGE: Detectable in crown cells of the embryonic node
CC from 7.5 dpc. Initial uniform expression develops asymmetrically with a
CC higher level on the left side of the node until expression disappears
CC around 13.5 dpc. Expressed in antrum pyloricum of the stomach from 11.5
CC dpc to 16.5 dpc and in dorsal tongue epithelium from 14.5 dpc to 16.5
CC dpc. {ECO:0000269|PubMed:14745963}.
CC -!- MISCELLANEOUS: Asymmetric expression in the embryonic node is dependent
CC on Invs and Dnahc11.
CC -!- SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA87581.3; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; U46068; AAA87581.3; ALT_FRAME; mRNA.
DR EMBL; AL732601; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC060982; AAH60982.1; -; mRNA.
DR EMBL; BC100436; AAI00437.1; -; mRNA.
DR CCDS; CCDS16927.1; -.
DR RefSeq; NP_001012392.1; NM_001012392.1.
DR RefSeq; NP_700467.2; NM_153418.2.
DR AlphaFoldDB; Q61114; -.
DR SMR; Q61114; -.
DR STRING; 10090.ENSMUSP00000080501; -.
DR GlyGen; Q61114; 4 sites.
DR iPTMnet; Q61114; -.
DR PhosphoSitePlus; Q61114; -.
DR MaxQB; Q61114; -.
DR PaxDb; Q61114; -.
DR PeptideAtlas; Q61114; -.
DR PRIDE; Q61114; -.
DR ProteomicsDB; 265228; -.
DR Antibodypedia; 10629; 192 antibodies from 23 providers.
DR DNASU; 228801; -.
DR Ensembl; ENSMUST00000028987; ENSMUSP00000028987; ENSMUSG00000027485.
DR Ensembl; ENSMUST00000081816; ENSMUSP00000080501; ENSMUSG00000027485.
DR GeneID; 228801; -.
DR KEGG; mmu:228801; -.
DR UCSC; uc008niw.1; mouse.
DR CTD; 92747; -.
DR MGI; MGI:2137431; Bpifb1.
DR VEuPathDB; HostDB:ENSMUSG00000027485; -.
DR eggNOG; KOG4160; Eukaryota.
DR GeneTree; ENSGT01020000230460; -.
DR HOGENOM; CLU_050473_0_0_1; -.
DR InParanoid; Q61114; -.
DR OMA; FNDMYAD; -.
DR OrthoDB; 862857at2759; -.
DR PhylomeDB; Q61114; -.
DR TreeFam; TF338541; -.
DR Reactome; R-MMU-6803157; Antimicrobial peptides.
DR BioGRID-ORCS; 228801; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Bpifb1; mouse.
DR PRO; PR:Q61114; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q61114; protein.
DR Bgee; ENSMUSG00000027485; Expressed in epithelium of stomach and 179 other tissues.
DR Genevisible; Q61114; MM.
DR GO; GO:0005576; C:extracellular region; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0002227; P:innate immune response in mucosa; ISO:MGI.
DR GO; GO:0034144; P:negative regulation of toll-like receptor 4 signaling pathway; ISO:MGI.
DR InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR InterPro; IPR021193; Bpifb1.
DR InterPro; IPR017942; Lipid-bd_serum_glycop_N.
DR PANTHER; PTHR47395; PTHR47395; 1.
DR Pfam; PF01273; LBP_BPI_CETP; 1.
DR PIRSF; PIRSF037186; PLUNC_long_form; 1.
DR SMART; SM00328; BPI1; 1.
DR SUPFAM; SSF55394; SSF55394; 2.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunity; Innate immunity;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..474
FT /note="BPI fold-containing family B member 1"
FT /id="PRO_0000017181"
FT CARBOHYD 153
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 160
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 263
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 400
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 157..200
FT /evidence="ECO:0000250"
FT CONFLICT 137
FT /note="Q -> R (in Ref. 3; AAH60982)"
FT /evidence="ECO:0000305"
FT CONFLICT 361
FT /note="V -> M (in Ref. 3; AAH60982)"
FT /evidence="ECO:0000305"
FT CONFLICT 395
FT /note="M -> T (in Ref. 3; AAI00437)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 474 AA; 52455 MW; 4CDF2CB13BA4F57A CRC64;
MAGPWIITLL CGLLGATLVQ ANVYPPAVLN LGPEVIQKHL TQALKDHDAT AILQELPLLR
AMQDKSGSIP ILDSFVHTVL RYIIWMKVTS ANILQLDVQP STYDQELVVR IPLDMVAGLN
TPLIKTIVEF QMSTEVQALI RVERSKSGPA HLNLSDCSSN ESTLRLSLLH KLSFVVNSLA
KNVMNLLVPA LPQIVKNHLC PVIQQAFDDM YEDFLRLTTA PIALSPGALE FGLLSPAIQD
SNILLNLKAK LLDSQARVTN WFNNSATSLM ETTPDRAPFS LTVRQDLVNA IVTTLVPKEE
LVILLRFVIP DVARQLQMDI KEINAEAANK LGPTQMLKIF THSTPHIVLN EGSARAAQSV
VLEVFPTNTD VRPFFSLGIE ASYEAQFFTE DNRLMLNFNN VSIERIKLMI SDIKLFDPEV
LKDTLTKILE YTLLPNENGK LRTGVPMSMS KALGYEKAMW SVSKGALKLT PASS
