TAF1B_CHICK
ID TAF1B_CHICK Reviewed; 582 AA.
AC Q5ZJR9; F1NKU3;
DT 18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2012, sequence version 2.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=TATA box-binding protein-associated factor RNA polymerase I subunit B;
DE AltName: Full=RNA polymerase I-specific TBP-associated factor 63 kDa;
DE Short=TAFI63;
DE AltName: Full=TATA box-binding protein-associated factor 1B;
DE Short=TBP-associated factor 1B;
GN Name=TAF1B; ORFNames=RCJMB04_16d10;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Red jungle fowl;
RX PubMed=15592404; DOI=10.1038/nature03154;
RA Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P.,
RA Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B.,
RA Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C.,
RA Fulton R.S., Graves T.A., Kremitzki C., Layman D., Magrini V.,
RA McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O.,
RA Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W.,
RA Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D.,
RA Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K.,
RA Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L.,
RA Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B.,
RA Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M.,
RA Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M.,
RA Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S.,
RA Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M.,
RA Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M.,
RA Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A.,
RA Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S.,
RA Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J.,
RA Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J.,
RA Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E.,
RA Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M.,
RA Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A.,
RA Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E.,
RA Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S.,
RA Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E.,
RA Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R.,
RA Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R.,
RA Wilson R.K.;
RT "Sequence and comparative analysis of the chicken genome provide unique
RT perspectives on vertebrate evolution.";
RL Nature 432:695-716(2004).
CC -!- FUNCTION: Component of RNA polymerase I core factor complex that acts
CC as a GTF2B/TFIIB-like factor and plays a key role in multiple steps
CC during transcription initiation such as pre-initiation complex (PIC)
CC assembly and postpolymerase recruitment events in polymerase I (Pol I)
CC transcription. Binds rDNA promoters and plays a role in Pol I
CC recruitment (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- DOMAIN: Although it shares weak sequence similarity with GTF2B/TFIIB,
CC displays a similar subdomain organization as GTF2B/TFIIB, with a N-
CC terminal zinc finger, a connecting region (composed of B-reader and B-
CC linker regions), followed by 2 cyclin folds. The RRN7-type zinc finger
CC plays an essential postrecruitment role in Pol I transcription at a
CC step preceding synthesis of the first 40 nucleotides (By similarity).
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RRN7/TAF1B family. {ECO:0000305}.
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DR EMBL; AJ720365; CAG32024.1; -; mRNA.
DR EMBL; AADN02018707; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AADN02018708; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001006416.1; NM_001006416.1.
DR AlphaFoldDB; Q5ZJR9; -.
DR STRING; 9031.ENSGALP00000026465; -.
DR PaxDb; Q5ZJR9; -.
DR PRIDE; Q5ZJR9; -.
DR Ensembl; ENSGALT00000026516; ENSGALP00000026465; ENSGALG00000038495.
DR GeneID; 421933; -.
DR KEGG; gga:421933; -.
DR CTD; 9014; -.
DR VEuPathDB; HostDB:geneid_421933; -.
DR eggNOG; ENOG502QVGU; Eukaryota.
DR GeneTree; ENSGT00940000157612; -.
DR HOGENOM; CLU_032815_0_0_1; -.
DR InParanoid; Q5ZJR9; -.
DR OrthoDB; 329399at2759; -.
DR PRO; PR:Q5ZJR9; -.
DR Proteomes; UP000000539; Chromosome 3.
DR Bgee; ENSGALG00000038495; Expressed in spermatocyte and 13 other tissues.
DR ExpressionAtlas; Q5ZJR9; baseline and differential.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0001164; F:RNA polymerase I core promoter sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007420; P:brain development; IBA:GO_Central.
DR GO; GO:0021915; P:neural tube development; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0001188; P:RNA polymerase I preinitiation complex assembly; ISS:UniProtKB.
DR InterPro; IPR021752; TF_Rrn7_Zf.
DR Pfam; PF11781; zf-RRN7; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..582
FT /note="TATA box-binding protein-associated factor RNA
FT polymerase I subunit B"
FT /id="PRO_0000416870"
FT ZN_FING 4..39
FT /note="RRN7-type"
FT REGION 40..68
FT /note="B-reader"
FT /evidence="ECO:0000250"
FT REGION 69..73
FT /note="B-linker"
FT /evidence="ECO:0000250"
FT REGION 74..255
FT /note="N-terminal cyclin fold"
FT /evidence="ECO:0000250"
FT REGION 256..366
FT /note="C-terminal cyclin fold"
FT /evidence="ECO:0000250"
FT BINDING 13
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 16
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 31
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 34
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT CONFLICT 159
FT /note="S -> I (in Ref. 1; CAG32024)"
FT /evidence="ECO:0000305"
FT CONFLICT 451
FT /note="I -> N (in Ref. 1; CAG32024)"
FT /evidence="ECO:0000305"
FT CONFLICT 560
FT /note="V -> A (in Ref. 1; CAG32024)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 582 AA; 67314 MW; C5350CDCE287625D CRC64;
MDEEDAGDFN ERCAQCSEVN WGLTDGGRFY CRTCHNVIER TREVVSTDVI PNARVQTISK
GSRSQKKTDE GWEWYVCEGF QLVLKQQAEA LEALGVCPQM KDEVLCNFWR RYLQKSQQAY
CNRPAGETIK ALSVCDSSTD MDSEPEQHSL LHFLSVSESD GDLQTDCSYA SSAGKVSEST
SVCSGSVDGS LYVRKNRKEK LRMSMPMTLS FCYMALLWLK EPMTLSDLLR FVVEGHIPYF
NAYQHFPEKM KLYGLDLRIF CVESWPVYEE VYNKMVELAA FLDLPRFPDI TDNCFLHPDV
LCMKYLMEAN LPDELHNWTC RLVKKTSIGE VDFLTLTPGN KSTRKVKYDV LAAAVIVVVL
KLLFLLDDHY EWLLSDFSAE GNKNNKEGEG GPYFEFKKWY RVIKCTLDVE QKKLDEEKAK
YLWKCEKPLF YSVKKKSKIL RRRQMVENLQ IQFGKLSGSV QPAGRPNPSS FLLSWSEEST
DGSCFHGHSL KGILQEKHGL LTAINTDYWL CTDKLCNEKL CGHLAHYREE DFPKSYHFVL
RLFSFLLRIQ PSSIHEEVCV IEHKLFNKKL YKKPKRKRSL RK
