ID   BPIB1_RAT               Reviewed;         471 AA.
AC   A0JPN3;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=BPI fold-containing family B member 1;
DE   AltName: Full=Long palate, lung and nasal epithelium carcinoma-associated protein 1;
DE   Flags: Precursor;
GN   Name=Bpifb1; Synonyms=Lplunc1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:AAI27516.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung {ECO:0000312|EMBL:AAI27516.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May play a role in innate immunity in mouth, nose and lungs.
CC       Binds bacterial lipopolysaccharide (LPS) and modulates the cellular
CC       responses to LPS (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
CC       {ECO:0000255}.
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DR   EMBL; BC127515; AAI27516.1; -; mRNA.
DR   RefSeq; NP_001071148.2; NM_001077680.1.
DR   AlphaFoldDB; A0JPN3; -.
DR   SMR; A0JPN3; -.
DR   STRING; 10116.ENSRNOP00000052209; -.
DR   GlyGen; A0JPN3; 4 sites.
DR   iPTMnet; A0JPN3; -.
DR   PhosphoSitePlus; A0JPN3; -.
DR   PaxDb; A0JPN3; -.
DR   PRIDE; A0JPN3; -.
DR   GeneID; 499926; -.
DR   KEGG; rno:499926; -.
DR   UCSC; RGD:1563047; rat.
DR   CTD; 92747; -.
DR   RGD; 1563047; Bpifb1.
DR   eggNOG; KOG4160; Eukaryota.
DR   HOGENOM; CLU_050473_0_0_1; -.
DR   InParanoid; A0JPN3; -.
DR   OrthoDB; 862857at2759; -.
DR   PhylomeDB; A0JPN3; -.
DR   Reactome; R-RNO-6803157; Antimicrobial peptides.
DR   PRO; PR:A0JPN3; -.
DR   Proteomes; UP000002494; Unplaced.
DR   Genevisible; A0JPN3; RN.
DR   GO; GO:0005576; C:extracellular region; ISO:RGD.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   GO; GO:0002227; P:innate immune response in mucosa; ISO:RGD.
DR   GO; GO:0034144; P:negative regulation of toll-like receptor 4 signaling pathway; ISO:RGD.
DR   InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR   InterPro; IPR021193; Bpifb1.
DR   InterPro; IPR001124; Lipid-bd_serum_glycop_C.
DR   InterPro; IPR017942; Lipid-bd_serum_glycop_N.
DR   PANTHER; PTHR47395; PTHR47395; 1.
DR   Pfam; PF01273; LBP_BPI_CETP; 1.
DR   Pfam; PF02886; LBP_BPI_CETP_C; 1.
DR   SMART; SM00328; BPI1; 1.
DR   SUPFAM; SSF55394; SSF55394; 2.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Immunity; Innate immunity;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..471
FT                   /note="BPI fold-containing family B member 1"
FT                   /id="PRO_0000274547"
FT   CARBOHYD        150
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        157
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        260
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        397
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        154..197
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   471 AA;  52219 MW;  423B45086A31C69E CRC64;
     MTNPWIVSLL LGATLVQANL YPPAVLNLGP EVIKKHLTQA LENHDATAIL QELPLLRGMQ
     DKSGSIPILD SFVNTVLRYI IWMKVTSANI LQLVVQPSTY DQELVVRIPL DMVAGLNTPL
     IKTIVEFQMS TEVQALIRVE RSKNGPARLN LSDCSSNEST LRLSLLHKLS FVVNSLAKNV
     MNLLMPALPQ IVKSHLCPVI QQAFDDMYED FLRLTTAPIA LSPGALEFDL LSPAIQDSNI
     LFNLKAKLLD SQARVTNWFN GSATPLMETT PDRAPFSLTV RQDLVNAIVT TLIPQEELVI
     LLRFVIPDVA RQLQMDIKEI NAEAANKLGP TQMLKIFTHS TPHIVLNEGG ATAAQSVVLE
     VFPTNTDVRP FFSLGIEASY EAQFFIAENR LMLNFNNVSI ERIKLMISDI KLFDPEVLKD
     TLTKILEYTL LPNENGKLRT GIPMSMPKAL GYEKAMWSVS KGALKLTPAS S