TAF1B_XENTR
ID TAF1B_XENTR Reviewed; 596 AA.
AC F7BLM1;
DT 18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 1.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=TATA box-binding protein-associated factor RNA polymerase I subunit B;
DE AltName: Full=RNA polymerase I-specific TBP-associated factor 63 kDa;
DE Short=TAFI63;
DE AltName: Full=TATA box-binding protein-associated factor 1B;
DE Short=TBP-associated factor 1B;
GN Name=taf1b;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
CC -!- FUNCTION: Component of RNA polymerase I core factor complex that acts
CC as a GTF2B/TFIIB-like factor and plays a key role in multiple steps
CC during transcription initiation such as pre-initiation complex (PIC)
CC assembly and postpolymerase recruitment events in polymerase I (Pol I)
CC transcription. Binds rDNA promoters and plays a role in Pol I
CC recruitment (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- DOMAIN: Although it shares weak sequence similarity with GTF2B/TFIIB,
CC displays a similar subdomain organization as GTF2B/TFIIB, with a N-
CC terminal zinc finger, a connecting region (composed of B-reader and B-
CC linker regions), followed by 2 cyclin folds. The RRN7-type zinc finger
CC plays an essential postrecruitment role in Pol I transcription at a
CC step preceding synthesis of the first 40 nucleotides (By similarity).
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RRN7/TAF1B family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAMC01085723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01085724; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01085725; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01085726; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01085727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01085728; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002938934.1; XM_002938888.4.
DR AlphaFoldDB; F7BLM1; -.
DR STRING; 8364.ENSXETP00000015280; -.
DR PaxDb; F7BLM1; -.
DR PRIDE; F7BLM1; -.
DR Ensembl; ENSXETT00000015280; ENSXETP00000015280; ENSXETG00000007011.
DR GeneID; 100379921; -.
DR KEGG; xtr:100379921; -.
DR CTD; 9014; -.
DR Xenbase; XB-GENE-992275; taf1b.
DR eggNOG; ENOG502QVGU; Eukaryota.
DR HOGENOM; CLU_032815_0_0_1; -.
DR InParanoid; F7BLM1; -.
DR OMA; PRSFVWL; -.
DR OrthoDB; 329399at2759; -.
DR PhylomeDB; F7BLM1; -.
DR TreeFam; TF324353; -.
DR Reactome; R-XTR-5250924; B-WICH complex positively regulates rRNA expression.
DR Reactome; R-XTR-73762; RNA Polymerase I Transcription Initiation.
DR Proteomes; UP000008143; Chromosome 5.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000007011; Expressed in 4-cell stage embryo and 12 other tissues.
DR GO; GO:0070860; C:RNA polymerase I core factor complex; IBA:GO_Central.
DR GO; GO:0005668; C:RNA polymerase transcription factor SL1 complex; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0001164; F:RNA polymerase I core promoter sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0042790; P:nucleolar large rRNA transcription by RNA polymerase I; IBA:GO_Central.
DR GO; GO:0001188; P:RNA polymerase I preinitiation complex assembly; ISS:UniProtKB.
DR InterPro; IPR033599; TAF1B/Rrn7.
DR InterPro; IPR021752; TF_Rrn7_Zf.
DR PANTHER; PTHR31576; PTHR31576; 1.
DR Pfam; PF11781; zf-RRN7; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..596
FT /note="TATA box-binding protein-associated factor RNA
FT polymerase I subunit B"
FT /id="PRO_0000416873"
FT ZN_FING 4..39
FT /note="RRN7-type"
FT REGION 40..69
FT /note="B-reader"
FT /evidence="ECO:0000250"
FT REGION 70..74
FT /note="B-linker"
FT /evidence="ECO:0000250"
FT REGION 75..263
FT /note="N-terminal cyclin fold"
FT /evidence="ECO:0000250"
FT REGION 264..374
FT /note="C-terminal cyclin fold"
FT /evidence="ECO:0000250"
FT REGION 575..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..596
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 13
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 16
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 31
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 34
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
SQ SEQUENCE 596 AA; 69304 MW; 77C5F71B5E753275 CRC64;
MEEEDARGYN KPCPQCSEVN WAISDEGTFY CKSCHTVIEK TREVDDTEVF STHGKLQSIS
RGLRKKRKLE KGWEWYVCEG FQFILIKQAE ALQALGVAPQ IKDEILCTFW RRYLQKTNQA
YVKRPVYRSV LTCRDSDSSA TEVDSDLEAF SIGTSSVSDG YTSDASGRLS LPTEDIPSAS
ESAVSVHSGS VDGLSHVKMR KNFKPWNYVK MTMPMTLAFC YLALLWLRAS ITLSDLLRFV
FEKHIPYINA HQYLPEEIKV YGHDVRIFRM QALPVYNDIL SKAYELGAFL DLPQFPPITK
NCYLHPSVLC MKYLIEANLP DELQQWTCQV AEKTGIDDFH RLTFDPACKR ASHIRYDVQA
VALIILVLKL LFALDDNTEW QLSKFAERMN QSNKEKTVFD LQSWYQTVRQ CYEKAQQKLE
EEYGRFMWKS DCPLYYSQTT KSLLQKRKQM SENLQRQFSK LAGAAPNTGK QGPSSFLFKW
EEQNTDTISF HGHSLQAVLH QGKKPPTPIN THYWLNSLRK CKTRICQHSE LYEESNFPRS
YHFMVCLFAF LLRVEHCVIH HEVGLIEELF FQEKKNKRKQ KPKKQEMTDF REVPPD
