TAF1_DICDI
ID TAF1_DICDI Reviewed; 2310 AA.
AC Q54DH8;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Transcription initiation factor TFIID subunit 1;
GN Name=taf1; Synonyms=TFIID1; ORFNames=DDB_G0292242;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16596165; DOI=10.1371/journal.pgen.0020038;
RA Goldberg J.M., Manning G., Liu A., Fey P., Pilcher K.E., Xu Y., Smith J.L.;
RT "The dictyostelium kinome -- analysis of the protein kinases from a simple
RT model organism.";
RL PLoS Genet. 2:E38-E38(2006).
CC -!- FUNCTION: May be a component of the TFIID basal transcription factor
CC complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TAF1 family. {ECO:0000305}.
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DR EMBL; AAFI02000188; EAL61331.1; -; Genomic_DNA.
DR RefSeq; XP_629749.1; XM_629747.1.
DR AlphaFoldDB; Q54DH8; -.
DR SMR; Q54DH8; -.
DR STRING; 44689.DDB0220687; -.
DR PaxDb; Q54DH8; -.
DR PRIDE; Q54DH8; -.
DR EnsemblProtists; EAL61331; EAL61331; DDB_G0292242.
DR GeneID; 8628578; -.
DR KEGG; ddi:DDB_G0292242; -.
DR dictyBase; DDB_G0292242; taf1.
DR eggNOG; KOG0008; Eukaryota.
DR HOGENOM; CLU_230071_0_0_1; -.
DR InParanoid; Q54DH8; -.
DR OMA; KHEFRDD; -.
DR Reactome; R-DDI-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-DDI-73776; RNA Polymerase II Promoter Escape.
DR Reactome; R-DDI-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR Reactome; R-DDI-75953; RNA Polymerase II Transcription Initiation.
DR Reactome; R-DDI-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR PRO; PR:Q54DH8; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0005669; C:transcription factor TFIID complex; ISS:dictyBase.
DR GO; GO:0004402; F:histone acetyltransferase activity; ISS:dictyBase.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IBA:GO_Central.
DR GO; GO:0001091; F:RNA polymerase II general transcription initiation factor binding; IEA:InterPro.
DR GO; GO:0017025; F:TBP-class protein binding; IBA:GO_Central.
DR GO; GO:0051123; P:RNA polymerase II preinitiation complex assembly; IBA:GO_Central.
DR Gene3D; 1.20.920.10; -; 1.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR040240; TAF1.
DR InterPro; IPR022591; TAF1_HAT_dom.
DR PANTHER; PTHR13900; PTHR13900; 3.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF12157; DUF3591; 1.
DR SMART; SM00297; BROMO; 1.
DR SUPFAM; SSF47370; SSF47370; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
PE 3: Inferred from homology;
KW Bromodomain; Coiled coil; Nucleus; Reference proteome.
FT CHAIN 1..2310
FT /note="Transcription initiation factor TFIID subunit 1"
FT /id="PRO_0000376869"
FT DOMAIN 2129..2199
FT /note="Bromo"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00035"
FT REGION 115..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 330..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 395..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 755..778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 802..862
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 937..968
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1417..1494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1558..1616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1648..2111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2244..2289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 80..150
FT /evidence="ECO:0000255"
FT COILED 809..846
FT /evidence="ECO:0000255"
FT COILED 1422..1522
FT /evidence="ECO:0000255"
FT COILED 1574..1604
FT /evidence="ECO:0000255"
FT COILED 1946..2004
FT /evidence="ECO:0000255"
FT COMPBIAS 115..138
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..279
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..631
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..686
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 812..851
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 937..964
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1417..1453
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1474..1494
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1558..1587
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1648..1729
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1730..1874
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1897..2097
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2244..2266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2310 AA; 259629 MW; 523E54F591BF2C99 CRC64;
MAKDKEKKGN LTGFLFGNVK ESGELDVEEN DQVFKDLKKD LELFAKSSQH ISFKKTIGID
EDDKNAVTDS VIVPDKNALD YEDIDEVAEE IQSTENEINK LNADKLANAA IARLQQQHKE
REEQQRLKLL EQQQRQLSKK ERRKQRKQVG SKQPLQIKKK PSVDDFDFDE EEEQQQQKST
RSEDEDDDDI SSASSLSSSS ASSSASSSRS PSMSRSASDI ESDSMSDSSR SSGSSISSRS
SISSSSSRSD SDSDGGGGGG GGGGGSHRRR HKEKKPKKKV TMKAGSYEVV KSILETPEMF
TPEDQEFKVF VSGKSSEGFI LKFSQLFAPK FPDKPTRKKS RKTRFSTPQT LNDDSIETDE
LLLWNQPSKK QPPPSIIKKP ITEIDSITKQ LLKSNAGITS STGGGGEEDT LTSSNTTTPT
LTSMQLYQAA AEEDEEYVPE PLRETEDEEI MTMFYMVPDS NYHSLQQVNW EDNIIWDEES
LIKFKKSDHF NQFYLSSDNQ QQNIIIKEAI TMPVEINDLT PNLNKNSKQT SSSSTTTSTT
TTTSTTTTTT TTTTATTLSS TSTSTTTQRN NKNKNKNNNN NINNSSKLFG LDHISEKEEI
MDTDSQNLLQ QPLSQEKDKE KEKDKDKAQN EQHIQTIVNN KKNSTTNNNN LTNNNGNNNN
TNNNNNNSNN NSNNNNNNNN NNKQNNNKEI DEIMKSNIDK WSLFPISNQE LENGDWIDNI
IWDESMVPEK IQQVSMLILD LNDREMYFEE HIEKKEHNNG ESGSNGDQQA PVKKKSKKKL
ALEAAQAAQA AALERAQAAA RAANGQTMSF EEQLQKDKEE DERKEREERE QSQREIDKFN
LSNDKFYRPV RKPPPRPPNG STKVVIQHSL PGIKLSLVKT HLTKEDLIYA HRPRILFPSN
VPFRIIIYNK EGSLSGDLSS SSNNLLLNSS TNSIMGGHNM RGSINGGMMS SSSSSSSSSS
KKSLHKSDLS ARDGRLVLIE YTEQHPPLVS NVGMGLRIRN YYKKKNTHDT GPKDLNFEDG
ELVMLDNNEE SPFLGDINPG QTIQSVVNNL FKVPIHKHNS ANTDFLLVKS RDGKRWYIRD
VGPIYAAGQI LPEVEVPAPN SRNANMFLKS RLQAYIYRQF LKKSNPQRRL KITDICSAFP
SQSETSIRKR LKDCADFQRG GDDSGWWTVK DNFTLPTEEE FQKLVTPEAV VSFESMLIGL
QRLQDNGIIH FTAPGTIPTI LGNLDDEDPI KKSIKPVEDE LSITPWNLTG SFLSAMQGKG
RLQIISDDPT GREDEYSYLK MPQKVVNQKQ KAIKLALQKN QVTGTDADLR KLSLSASKTV
LLELGVDEET INKLARWQRI DLVRKKSSEA ALASNSNAAM TKFARGSRYS LDHQNLQYKE
QCQLVFDNQI KAIAGKGDDL YDEDLDADLL KDLEDSLFGD SNQSQNQNQN QNQNQNQSNN
NNNKSSSKST GKRSRSLFSR DESDEEEDNE EEEYNKLMGT KNKDEESKAK AKAKAEEEEI
KAKAEEAKAK AKAKAEEDDL TQGDRVFVKR TTLFQKPDGS LFKRIEIIRD PKVVQDYQKK
KHDQFLQDRK KFGKQNEEDE ETKKQRRRIQ ERLRRLKKND QREDSFNMNS SNSSIGATIG
SSNMINISAG NIPVSNINNN NYNNNNNNNN FSLNTSSSNK PIPPHRSSSS GIGSSGSNNN
SNTDRDQTRI SIVMPNQQAN SDSNSSSSTK IRIGQSSSSS SSSSSSSGHP RSSDREHRSS
EHRSGEHRSS EHRSSEHRGS EHRSSEHRSG EHSSHHRSSE HRSGDREHRS SDRGDREHRS
SEHRSSEHRS SEHRSSEHRS GDKEHRSDRE HRSSEHRSGD REHRSDREHR EHRSGDREHR
SDREHREHRS ERSRNSSSGS SSSSRDHRDS HHRNSTGSSS DSHSSSHHSS SNRDSNHNGG
SSSNNNNNNS NNNHNNNNNS NNNNNNNNNN NNNNNINNNN NNNNNINNIN NNNNNNINNI
NNNYNNNNNN NNNNNNNNNN NNNNNNINNN ENNNTNNLSN STNQSPTLSQ SGIIIRYNGS
NSGNSNNTNG GNNRTEDQSV LNTPLSASSS GSNRKKRTLD QSNSESPSLS STTLDGSDKS
SRRNRVRKDG SGADVELSNI FERILDKLRT NDEFIAFRHK VTPKLAPDYH KVIKNPIDLT
TMRDRNRHWE YKSKNQFIDA IKLMVANCFE YNEKRFSHLL PIAEKLLTST LQLLAPFDSQ
IGDLEKSIEQ TNLKQSSSSL LLSVDHTNGS TPSTPITLNT PITPNLPSNS PFFPPVDPPS
KAHHSAEDEE IDIVSLYESG VSPSVKNNFN
