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TAF2_ARATH
ID   TAF2_ARATH              Reviewed;        1390 AA.
AC   Q8LPF0; F4HTS1; Q6SJQ9; Q9C9B7;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 123.
DE   RecName: Full=Transcription initiation factor TFIID subunit 2;
DE   AltName: Full=TBP-associated factor 2;
DE            Short=AtTAF2;
GN   Name=TAF2; OrderedLocusNames=At1g73960; ORFNames=F2P9.17;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION, NOMENCLATURE, AND TISSUE
RP   SPECIFICITY.
RX   PubMed=15527982; DOI=10.1016/j.gene.2004.08.023;
RA   Lago C., Clerici E., Mizzi L., Colombo L., Kater M.M.;
RT   "TBP-associated factors in Arabidopsis.";
RL   Gene 342:231-241(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX   PubMed=17340043; DOI=10.1007/s11103-007-9135-1;
RA   Lawit S.J., O'Grady K., Gurley W.B., Czarnecka-Verner E.;
RT   "Yeast two-hybrid map of Arabidopsis TFIID.";
RL   Plant Mol. Biol. 64:73-87(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
CC   -!- FUNCTION: TAFs are components of the transcription factor IID (TFIID)
CC       complex that is essential for mediating regulation of RNA polymerase
CC       transcription. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the TFIID complex. TFIID is composed of TATA
CC       binding protein (TBP) and a number of TBP-associated factors (TAFs)
CC       whose MWs range from 14-217 kDa.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8LPF0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8LPF0-2; Sequence=VSP_053299;
CC   -!- TISSUE SPECIFICITY: Expressed in roots, leaves and inflorescences.
CC       {ECO:0000269|PubMed:15527982}.
CC   -!- SIMILARITY: Belongs to the TAF2 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG52531.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AY457045; AAR21621.1; -; mRNA.
DR   EMBL; AC016662; AAG52531.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE35530.1; -; Genomic_DNA.
DR   EMBL; AY102124; AAM26691.1; -; mRNA.
DR   PIR; C96767; C96767.
DR   RefSeq; NP_177536.2; NM_106055.5. [Q8LPF0-1]
DR   AlphaFoldDB; Q8LPF0; -.
DR   SMR; Q8LPF0; -.
DR   BioGRID; 28952; 4.
DR   IntAct; Q8LPF0; 2.
DR   STRING; 3702.AT1G73960.1; -.
DR   iPTMnet; Q8LPF0; -.
DR   PaxDb; Q8LPF0; -.
DR   PRIDE; Q8LPF0; -.
DR   ProteomicsDB; 233008; -. [Q8LPF0-1]
DR   EnsemblPlants; AT1G73960.1; AT1G73960.1; AT1G73960. [Q8LPF0-1]
DR   GeneID; 843733; -.
DR   Gramene; AT1G73960.1; AT1G73960.1; AT1G73960. [Q8LPF0-1]
DR   KEGG; ath:AT1G73960; -.
DR   Araport; AT1G73960; -.
DR   TAIR; locus:2031571; AT1G73960.
DR   eggNOG; KOG1932; Eukaryota.
DR   HOGENOM; CLU_005057_0_0_1; -.
DR   InParanoid; Q8LPF0; -.
DR   OrthoDB; 142542at2759; -.
DR   PhylomeDB; Q8LPF0; -.
DR   PRO; PR:Q8LPF0; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q8LPF0; baseline and differential.
DR   Genevisible; Q8LPF0; AT.
DR   GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR   GO; GO:0005669; C:transcription factor TFIID complex; IBA:GO_Central.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IBA:GO_Central.
DR   Gene3D; 1.10.390.10; -; 1.
DR   Gene3D; 2.60.40.1730; -; 1.
DR   InterPro; IPR042097; Aminopeptidase_N-like_N_sf.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014782; Peptidase_M1_dom.
DR   InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR   InterPro; IPR037813; TAF2.
DR   PANTHER; PTHR15137; PTHR15137; 1.
DR   Pfam; PF01433; Peptidase_M1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF63737; SSF63737; 1.
PE   2: Evidence at transcript level;
KW   Activator; Alternative splicing; Coiled coil; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..1390
FT                   /note="Transcription initiation factor TFIID subunit 2"
FT                   /id="PRO_0000424039"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1104..1132
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1240..1377
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1286..1333
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1104..1121
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1240..1261
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1285..1313
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1339..1357
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         910..929
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:17340043"
FT                   /id="VSP_053299"
FT   CONFLICT        1350
FT                   /note="E -> D (in Ref. 2; AAR21621)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1390 AA;  155748 MW;  718EE64B69F0FF47 CRC64;
     MAKARKPKNE EAPGAKTSEN TGAKVLHQKL FLSIDFKKRQ IYGYTELEVS VPDIGIVGLH
     AENLGIESVL VDGEPTVFEY YPHHQNSETE SNWNSVSDPA SAADAAAMEY VGVLKREDTA
     NLLINCCKPS KDLSEQLDSV TLENGSQSSG EAKQNVKLIR INYWVEKIES GIHFDGNIVH
     TDNQMRRARC WFPCIDDEYH RCSFDLEFTV PHNFVAVSVG KLLYQVMCKE DTTQKTYVYE
     LAIPIAPRWV SLVAGPLEIL PDQTNFLISN LCLPHDLSRL RNTMEFFHEA YSYYEDYLSA
     NFPFGFYKQV FLPPEMVVTS STSGASLSIF SSHILYDERV IDQTIDTRIK LASALAKQWF
     GVYITPESPN DDWLLDGLAG FLTDMFIKQF LGNNEARYRR YKANCAVCKA DDSGAMCLSS
     SPSCRDLFGT HSIGMHGKIR SWKSGAVLQM LEKQMGSDSF RKILQKIISR AKDPSNSIRS
     LSTKEFRQFA NKIGNLERPF LKEFFQRWVA SYGCPVLRIG LSYNKRKNNV EMAALRECTA
     ALDARLSVIG ATSDSESRDV DAGWPGIMSI RVYELDGMSD HPKLPMAGDR WQLLELPCHS
     KLAAKRYQKP KKGGKPDGAE DNVDAIAPLE NKTSIESPLA WIKADPEMEY IAEIHLHQPL
     QMWVNQLEKD GDVVAQAQAI ASLEALKQHS FSIVNALKNV LTDSKVFWRI RIAAAFALAK
     TASEESDWAG LQHLIKFYKS RRFDAEIGLP KPNDFRDFPE YFVLEAIPHA IAIVRGAEGK
     SPREAVEFIL QLLKYNDNSG NSYSDVFWLA VLVQSVGDLE FCQQSLTFLA PLLKRIDRLL
     QFDRLMPSYN GILTISCIRT LAQTALKLSD SISFDHICKL IEPFRNSDTI LQIRIEGSRA
     LLDIEYQSKG ISSALLLFMK YLVEESSLRG QVKLCVHTMR LCQIAVGCDS DDCVDTVTLL
     DLLHLFKSHV VFNNELLRYY LFCIFQILAG RPPTLFGVPK EKPLQLVDVE ACIEPKNVFL
     VPGAEAGEPS LSALGDAKGQ SLDVAPYGVP IIPQEMFMPI VPELMLPEPV AAYDETQHLE
     PRMESQNQPS HENPIVHEIP SDVEGPTEEL AHREANPPTK EPQKEPDVVS VSVSHEVKKS
     VIRIKVRPSG ATSRAEGSAR TIERSQGIVV RHDIDRGQTS SASVDAPQRI STDAVSISNQ
     NHVEEVNSCH DVGSRMTASI GSVKFASEGD IFGKELQCTA ESGKPSTSQK ADNNNRTVPP
     SFLPLDHSME NEAQQKYASL QTLSIGKEKE KKKDKEKKEK KRKREDPVYL EKKRLKKEKK
     RKEKEMAKLV SSTTDPAKKK IESVAEVKEE EPSDGAMLIK VEPKTEPSTA EARPLPKFRI
     KLKSKAFNNS
 
 
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