TAF2_DANRE
ID TAF2_DANRE Reviewed; 1191 AA.
AC Q32PW3; Q5BJ13; Q6DGD5; Q6DRH8;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Transcription initiation factor TFIID subunit 2;
DE AltName: Full=TBP-associated factor 150 kDa;
DE AltName: Full=Transcription initiation factor TFIID 150 kDa subunit;
DE Short=TAF(II)150;
DE Short=TAFII-150;
DE Short=TAFII150;
GN Name=taf2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RX PubMed=15256591; DOI=10.1073/pnas.0403929101;
RA Amsterdam A., Nissen R.M., Sun Z., Swindell E.C., Farrington S.,
RA Hopkins N.;
RT "Identification of 315 genes essential for early zebrafish development.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:12792-12797(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=SJD; TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The TFIID basal transcription factor complex plays a major
CC role in the initiation of RNA polymerase II (Pol II)-dependent
CC transcription. TFIID recognizes and binds promoters with or without a
CC TATA box via its subunit tbp, a TATA-box-binding protein, and promotes
CC assembly of the pre-initiation complex (PIC). The TFIID complex
CC consists of tbp and TBP-associated factors (TAFs).
CC {ECO:0000250|UniProtKB:Q6P1X5}.
CC -!- SUBUNIT: Component of the TFIID basal transcription factor complex,
CC composed of TATA-box-binding protein tbp, and a number of TBP-
CC associated factors (TAFs). {ECO:0000250|UniProtKB:Q6P1X5}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TAF2 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH76415.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC Sequence=AAH91664.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR EMBL; AY648781; AAT68099.1; -; mRNA.
DR EMBL; BC076415; AAH76415.1; ALT_SEQ; mRNA.
DR EMBL; BC091664; AAH91664.1; ALT_SEQ; mRNA.
DR EMBL; BC107957; AAI07958.1; -; mRNA.
DR RefSeq; NP_001003835.2; NM_001003835.2.
DR AlphaFoldDB; Q32PW3; -.
DR SMR; Q32PW3; -.
DR STRING; 7955.ENSDARP00000098846; -.
DR PaxDb; Q32PW3; -.
DR PRIDE; Q32PW3; -.
DR Ensembl; ENSDART00000165565; ENSDARP00000139157; ENSDARG00000102307.
DR GeneID; 324486; -.
DR KEGG; dre:324486; -.
DR CTD; 6873; -.
DR ZFIN; ZDB-GENE-030131-3207; taf2.
DR eggNOG; KOG1932; Eukaryota.
DR GeneTree; ENSGT00390000000420; -.
DR HOGENOM; CLU_002317_0_0_1; -.
DR InParanoid; Q32PW3; -.
DR OMA; GQESYEW; -.
DR OrthoDB; 142542at2759; -.
DR PhylomeDB; Q32PW3; -.
DR TreeFam; TF315208; -.
DR Reactome; R-DRE-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-DRE-6804756; Regulation of TP53 Activity through Phosphorylation.
DR Reactome; R-DRE-73776; RNA Polymerase II Promoter Escape.
DR Reactome; R-DRE-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR Reactome; R-DRE-75953; RNA Polymerase II Transcription Initiation.
DR Reactome; R-DRE-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR PRO; PR:Q32PW3; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 16.
DR Bgee; ENSDARG00000102307; Expressed in gastrula and 27 other tissues.
DR GO; GO:0005669; C:transcription factor TFIID complex; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IBA:GO_Central.
DR Gene3D; 1.10.390.10; -; 1.
DR Gene3D; 2.60.40.1730; -; 1.
DR InterPro; IPR042097; Aminopeptidase_N-like_N_sf.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR InterPro; IPR037813; TAF2.
DR PANTHER; PTHR15137; PTHR15137; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF63737; SSF63737; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..1191
FT /note="Transcription initiation factor TFIID subunit 2"
FT /id="PRO_0000252427"
FT REGION 1044..1064
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1113..1191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1132..1163
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1176..1191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 43
FT /note="F -> L (in Ref. 2; AAI07958)"
FT /evidence="ECO:0000305"
FT CONFLICT 393
FT /note="E -> D (in Ref. 2; AAH76415)"
FT /evidence="ECO:0000305"
FT CONFLICT 778
FT /note="F -> L (in Ref. 1; AAT68099)"
FT /evidence="ECO:0000305"
FT CONFLICT 1188
FT /note="S -> Y (in Ref. 1; AAT68099)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1191 AA; 136526 MW; 859AD24F7DE95D98 CRC64;
MNRKKDKGFE SPRPYKLTHQ VVCINNVNFQ RKSVIGYVEL TIFPTVVNLN RIKLNSKQCR
IYRVRVNDLE APFIYNDPTL EVCHHESKQR NLNYFSSAYT AAVSAVDPDA GNGELSIKVP
SELWKQGDEM KVMKVYIEFS LDQPKGGLHF VVPDVEGNMA ERAAHVFSFG NQNSSRFWFP
CVDSYSELCT WKLEFTVDAS MVAVSCGDLV ETVYTHDMRK KTYHYMLPIP TAAPNISMAV
GPFEILVDPY MHEVTHFCLP QLLPLLKHTM SYLHEIFEFY EEILTCRYPY SCFKTVFVDE
AYVQVSSYAS MSIFSTNLLH SGLIIDQTPM TRSFLAQALA QQFFGCFISR MSWADEWVLK
GISGYIYGLY LKKTFGVNEY RHWIKEELDK IVEYELKIGG VLLHPTFSGG KEKDNPTPHL
HFSIKHPHTL SWEYYKMFQC KAHLVMRLIE NRISMEFMLQ VFNKLLSLAS TASSQKYQSH
MWSQMLVSTS GFLKSISNVS GKDIGPLIKQ WVDQSGVVKF FGSFAFNRKR NVLELEIRQD
YTSSGTQKYV GPIKVTVQEL DGSFNHTLQI EENSLKHDIP CHSKSRRNKK KKIPLMNGEE
VDMDLSAMDA DSPLLWIRID PDMSILRKVE FEQADFMWQY QLRYERDVVA QEEAILALEK
FPTPPSRRAL TDILEQDQCF YKVRMHACFC LAKIANSMVS TWTGPPAMKS LFTRMFCCKS
CPNIVKTNNF ISFQSYFLQK TIPVAMAQLR DVQNLCPREV LSFILDLIKY NDNRKNKFSD
NYYRAELIDA LTNSLTPAIS INNEVRTVDS LNADVRLILE EITRFLNMEK LLPSYRNTIT
VSCLRAIRML QKNGHIPSDP TLFKSYAEYG HFVDVRIAAL EAVIDYTRVD RSSSELQWLL
DLVQNDPVHY VRHEILSMLA KNPPFTKAAD SSLCNEALVD QLWKLMNSGT CHDWRLRCDA
VNLYYTLFGL TRPSCLPLPE LGLVLNLKEK KAVLNPTIKS EQIPGLPEMT PSMTFINTLK
EEHVVMDPAL SGVAMAPLSL KRKAETPVGS APEPGQVLQE EPSAKITLKS REEEDIDMDT
VHDSQAFIYH HLNMLERPST PGKEPSSVEQ AILSMPGTPM PTLSKESTSS KHGEHHHHHH
HHHEHKKKKK KHKHKHKHKH KHESKDKDRD SHAFVNSPAS GLSIRSPSLS D
