TAF2_SCHPO
ID TAF2_SCHPO Reviewed; 1172 AA.
AC P87121;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 3.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Transcription initiation factor TFIID subunit 2;
DE AltName: Full=TBP-associated factor 2;
GN Name=taf2; ORFNames=SPAC3A12.05c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Functions as a component of the DNA-binding general
CC transcription factor complex TFIID. Binding of TFIID to a promoter
CC (with or without TATA element) is the initial step in pre-initiation
CC complex (PIC) formation. TFIID plays a key role in the regulation of
CC gene expression by RNA polymerase II through different activities such
CC as transcription activator interaction, core promoter recognition and
CC selectivity, TFIIA and TFIIB interaction, chromatin modification
CC (histone acetylation by taf1), facilitation of DNA opening and
CC initiation of transcription (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the DNA-binding general transcription factor
CC complex TFIID. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}. Note=Localizes at the barrier septum.
CC -!- SIMILARITY: Belongs to the TAF2 family. {ECO:0000305}.
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DR EMBL; CU329670; CAB08750.3; -; Genomic_DNA.
DR PIR; T38673; T38673.
DR RefSeq; NP_593331.2; NM_001018762.3.
DR AlphaFoldDB; P87121; -.
DR SMR; P87121; -.
DR BioGRID; 279539; 5.
DR STRING; 4896.SPAC3A12.05c.1; -.
DR iPTMnet; P87121; -.
DR MaxQB; P87121; -.
DR PaxDb; P87121; -.
DR PRIDE; P87121; -.
DR EnsemblFungi; SPAC3A12.05c.1; SPAC3A12.05c.1:pep; SPAC3A12.05c.
DR GeneID; 2543107; -.
DR KEGG; spo:SPAC3A12.05c; -.
DR PomBase; SPAC3A12.05c; taf2.
DR VEuPathDB; FungiDB:SPAC3A12.05c; -.
DR eggNOG; KOG1932; Eukaryota.
DR HOGENOM; CLU_002317_2_0_1; -.
DR InParanoid; P87121; -.
DR OMA; GQESYEW; -.
DR PhylomeDB; P87121; -.
DR Reactome; R-SPO-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-SPO-73776; RNA Polymerase II Promoter Escape.
DR Reactome; R-SPO-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR Reactome; R-SPO-75953; RNA Polymerase II Transcription Initiation.
DR Reactome; R-SPO-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR PRO; PR:P87121; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0032153; C:cell division site; HDA:PomBase.
DR GO; GO:0000785; C:chromatin; NAS:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0005669; C:transcription factor TFIID complex; ISO:PomBase.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; ISO:PomBase.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; ISO:PomBase.
DR Gene3D; 1.10.390.10; -; 1.
DR Gene3D; 2.60.40.1730; -; 1.
DR InterPro; IPR042097; Aminopeptidase_N-like_N_sf.
DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR InterPro; IPR037813; TAF2.
DR PANTHER; PTHR15137; PTHR15137; 1.
DR SUPFAM; SSF63737; SSF63737; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..1172
FT /note="Transcription initiation factor TFIID subunit 2"
FT /id="PRO_0000356181"
FT REGION 1131..1172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1172 AA; 133909 MW; A05485B885286ED8 CRC64;
MSQLVDVPAR GHQKVAIDID FASQTIIGRT DITVNPIDSN LQKIVLDCYQ AEIHSVYVNG
DLTKFSYSDA LKKLRIDEPN STVNQHHQLN LQYEALMNDL GGINIFLSKP PGDELRPLIV
SIDFSVHQPI FGITFVGIDP VDHRYPHVFT NNSIIPYSTC SWLPCVDGIW ERSTWEFEIT
LPKTLSSLMH REKTQPSDLN NGANGVDGHD DNYENNRFDH QFNLSNEPDL LEDHDIEVIC
CGDLLDQVTH PKDMRKKTVY FSVTTPVAPN YIAFAAGPFK HINLTDFREP EDDDAMGSSA
IDITGYYLPK YAEEVENTCV FLYKAMDFFV REYGSYPFNS FKLCFVDETN FPIISTPSLV
ISSNSILYPK DSLDQIYDST KTLTWALASQ WIGVYLIPKA WSDLWLIYGL SYYICGLFLK
KLMGNNDYRF RLKKQVYRLL ELDIGKPPIS QRNINIPIDP NTLDFIALKS PLVIHILERR
LTKTGGSLGM SRVIPKLLLQ VMSGDMLNGC LSTSHFLKTC EKASHMRLDV FAQQWIYGYG
YPIFRVVQRF NRKKMIIEMG IDQVQTKEAP RAPMSDKNFL SDAIRHLNNE SIPTGLPVFS
GPMTIRIHEA DGTPYEHVVE LKDSFTKLDI QYNTKYKRIS RNRSTKNVKR DGDHNGDDSD
YVIRSLGDVL QSDEDIERWH LYDYTKEEED TMATEAFEWI RVDADFEWIC DLRVRQPEHM
YVSQLQQDRD VVAQLETIRH FTSESFTVSQ QVSTVLLRTL LDNRYYYGIR QEAARALARC
AIPELDWVGY YHLRMAYLEK FCFKDSTIPK SNDFSNITEY YVKCAMLESF PNIRDRKGVT
PSSVKKLLLD LLCYNDNANN EFSDAYFICL LIDSLVEGLI PRGETVQYAF SDPEHMEFVN
QVINEIDRYM RIDACMPSFK NIITCKSLKA KLRLAQTFHL EFGPKELLPY TQEGNYVLVR
CIAFNLMLQA GALKYTPLIK YIFYILTNDL SPVVRRSLLY SVQDGLGALA RGGTKSDVAS
EDLIVEEDIT KAVEKRIDIT SRASISGAIE ALRNDLGQNH DFATEIWNAI NNPKSDLLTK
RNLLMICRVL YKAKSSLLVT LKIPSLIPRL RAIHLGKGKI VIKKAPLKQI TSKTKEKSTS
PTPPSITINP IKPKGPTLKI KLTNLRSTPP SH
