ID   BPIB3_HUMAN             Reviewed;         472 AA.
AC   P59826; Q5TDX7;
DT   29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   23-FEB-2022, sequence version 3.
DT   03-AUG-2022, entry version 143.
DE   RecName: Full=BPI fold-containing family B member 3 {ECO:0000305};
DE   AltName: Full=Ligand-binding protein RYA3;
DE   AltName: Full=Long palate, lung and nasal epithelium carcinoma-associated protein 3;
DE   Flags: Precursor;
GN   Name=BPIFB3 {ECO:0000312|HGNC:HGNC:16178}; Synonyms=C20orf185, LPLUNC3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND SUBCELLULAR LOCATION.
RC   TISSUE=Fetal brain;
RX   PubMed=12837268; DOI=10.1016/s0888-7543(03)00102-2;
RA   Andrault J.-B., Gaillard I., Giorgi D., Rouquier S.;
RT   "Expansion of the BPI family by duplication on human chromosome 20:
RT   characterization of the RY gene cluster in 20q11.21 encoding olfactory
RT   transporters/antimicrobial-like peptides.";
RL   Genomics 82:172-184(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA   Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA   Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA   Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA   Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA   Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA   Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA   Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA   Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA   Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA   Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=11971875; DOI=10.1093/hmg/11.8.937;
RA   Bingle C.D., Craven C.J.;
RT   "PLUNC: a novel family of candidate host defence proteins expressed in the
RT   upper airways and nasopharynx.";
RL   Hum. Mol. Genet. 11:937-943(2002).
CC   -!- FUNCTION: May have the capacity to recognize and bind specific classes
CC       of odorants. May act as a carrier molecule, transporting odorants
CC       across the mucus layer to access receptor sites. May serve as a primary
CC       defense mechanism by recognizing and removing potentially harmful
CC       odorants or pathogenic microorganisms from the mucosa or clearing
CC       excess odorant from mucus to enable new odorant stimuli to be received
CC       (By similarity). {ECO:0000250}.
CC   -!- INTERACTION:
CC       P59826; Q03828: EVX2; NbExp=3; IntAct=EBI-1055244, EBI-17280301;
CC       P59826; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-1055244, EBI-741158;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Cytoplasm
CC       {ECO:0000269|PubMed:12837268}. Note=According to PubMed:12837268, it is
CC       cytoplasmic.
CC   -!- TISSUE SPECIFICITY: Detected in nasal septal epithelium.
CC       {ECO:0000269|PubMed:11971875}.
CC   -!- SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAP84989.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AF549189; AAP84989.1; ALT_INIT; mRNA.
DR   EMBL; AL121756; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS13212.1; -.
DR   RefSeq; NP_872599.1; NM_182658.2.
DR   AlphaFoldDB; P59826; -.
DR   BioGRID; 131704; 5.
DR   IntAct; P59826; 3.
DR   STRING; 9606.ENSP00000364643; -.
DR   GlyGen; P59826; 3 sites.
DR   iPTMnet; P59826; -.
DR   PhosphoSitePlus; P59826; -.
DR   BioMuta; BPIFB3; -.
DR   DMDM; 73620973; -.
DR   jPOST; P59826; -.
DR   MassIVE; P59826; -.
DR   PaxDb; P59826; -.
DR   PeptideAtlas; P59826; -.
DR   PRIDE; P59826; -.
DR   ProteomicsDB; 57162; -.
DR   TopDownProteomics; P59826; -.
DR   Antibodypedia; 59271; 65 antibodies from 16 providers.
DR   DNASU; 359710; -.
DR   Ensembl; ENST00000375494.3; ENSP00000364643.3; ENSG00000186190.7.
DR   GeneID; 359710; -.
DR   KEGG; hsa:359710; -.
DR   UCSC; uc002wym.1; human.
DR   CTD; 359710; -.
DR   GeneCards; BPIFB3; -.
DR   HGNC; HGNC:16178; BPIFB3.
DR   HPA; ENSG00000186190; Not detected.
DR   MIM; 615717; gene.
DR   neXtProt; NX_P59826; -.
DR   PharmGKB; PA25727; -.
DR   VEuPathDB; HostDB:ENSG00000186190; -.
DR   eggNOG; KOG4160; Eukaryota.
DR   HOGENOM; CLU_031635_1_0_1; -.
DR   InParanoid; P59826; -.
DR   OMA; EWLSHVV; -.
DR   OrthoDB; 1099604at2759; -.
DR   PhylomeDB; P59826; -.
DR   TreeFam; TF315617; -.
DR   PathwayCommons; P59826; -.
DR   SignaLink; P59826; -.
DR   BioGRID-ORCS; 359710; 9 hits in 1065 CRISPR screens.
DR   GenomeRNAi; 359710; -.
DR   Pharos; P59826; Tdark.
DR   PRO; PR:P59826; -.
DR   Proteomes; UP000005640; Chromosome 20.
DR   RNAct; P59826; protein.
DR   Bgee; ENSG00000186190; Expressed in olfactory segment of nasal mucosa and 9 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   GO; GO:0045087; P:innate immune response; NAS:UniProtKB.
DR   InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR   InterPro; IPR032951; BPIFB3.
DR   InterPro; IPR001124; Lipid-bd_serum_glycop_C.
DR   InterPro; IPR017942; Lipid-bd_serum_glycop_N.
DR   PANTHER; PTHR46019:SF5; PTHR46019:SF5; 1.
DR   Pfam; PF01273; LBP_BPI_CETP; 1.
DR   Pfam; PF02886; LBP_BPI_CETP_C; 1.
DR   SMART; SM00328; BPI1; 1.
DR   SMART; SM00329; BPI2; 1.
DR   SUPFAM; SSF55394; SSF55394; 2.
PE   1: Evidence at protein level;
KW   Cytoplasm; Disulfide bond; Glycoprotein; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..472
FT                   /note="BPI fold-containing family B member 3"
FT                   /id="PRO_0000017170"
FT   CARBOHYD        138
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        284
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        453
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        160..195
FT                   /evidence="ECO:0000250"
FT   VARIANT         224
FT                   /note="V -> M (in dbSNP:rs4911290)"
FT                   /id="VAR_049742"
FT   VARIANT         286
FT                   /note="T -> M (in dbSNP:rs2093066)"
FT                   /id="VAR_049743"
FT   VARIANT         330
FT                   /note="H -> Q (in dbSNP:rs6057717)"
FT                   /id="VAR_049744"
FT   VARIANT         365
FT                   /note="Y -> C (in dbSNP:rs6059063)"
FT                   /id="VAR_049745"
FT   VARIANT         445
FT                   /note="P -> S (in dbSNP:rs378098)"
FT                   /id="VAR_049746"
SQ   SEQUENCE   472 AA;  49887 MW;  58541CB74C738E49 CRC64;
     MLALWSLLLL WGLATPCQEL LETVGTLARI DKDELGKAIQ NSLVGEPILQ NVLGSVTAVN
     RGLLGSGGLL GGGGLLGHGG VFGVVEELSG LKIEELTLPK VLLKLLPGFG VQLSLHTKVG
     MHCSGPLGGL LQLAAEVNVT SRVALAVSSR GTPILILKRC STLLGHISLF SGLLPTPLFG
     VVEQMLFKVL PGLLCPVVDS VLGVVNELLG AVLGLVSLGA LGSVEFSLAT LPLISNQYIE
     LDINPIVKSV AGDIIDFPKS RAPAKVPPKK DHTSQVMVPL YLFNTTFGLL QTNGALDMDI
     TPELVPSDVP LTTTDLAALL PEALGKLPLH QQLLLFLRVR EAPTVTLHNK KALVSLPANI
     HVLFYVPKGT PESLFELNSV MTVRAQLAPS ATKLHISLSL ERLSVKVASS FTHAFDGSRL
     EEWLSHVVGA VYAPKLNVAL DVGIPLPKVL NINFSNSVLE IVENAVVLTV AS