TAF4_ARATH
ID TAF4_ARATH Reviewed; 720 AA.
AC Q6SJR1; Q9SFY7;
DT 16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Transcription initiation factor TFIID subunit 4;
DE AltName: Full=TBP-associated factor 4;
DE Short=AtTAF4;
GN Name=TAF4; OrderedLocusNames=At1g27720; ORFNames=T22C5.17;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION, NOMENCLATURE, AND TISSUE
RP SPECIFICITY.
RX PubMed=15527982; DOI=10.1016/j.gene.2004.08.023;
RA Lago C., Clerici E., Mizzi L., Colombo L., Kater M.M.;
RT "TBP-associated factors in Arabidopsis.";
RL Gene 342:231-241(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH TAF5; TAF10; TAF12;
RP TAF12B; TAF15 AND TAF15B.
RX PubMed=17340043; DOI=10.1007/s11103-007-9135-1;
RA Lawit S.J., O'Grady K., Gurley W.B., Czarnecka-Verner E.;
RT "Yeast two-hybrid map of Arabidopsis TFIID.";
RL Plant Mol. Biol. 64:73-87(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: TAFs are components of the transcription factor IID (TFIID)
CC complex that is essential for mediating regulation of RNA polymerase
CC transcription. {ECO:0000250}.
CC -!- SUBUNIT: Component of the TFIID complex. TFIID is composed of TATA
CC binding protein (TBP) and a number of TBP-associated factors (TAFs)
CC whose MWs range from 14-217 kDa. Interacts with TAF5, TAF10, TAF12,
CC TAF12B, TAF15 and TAF15B. {ECO:0000269|PubMed:17340043}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, leaves and inflorescences.
CC {ECO:0000269|PubMed:15527982}.
CC -!- SIMILARITY: Belongs to the TAF4 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF24960.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY457043; AAR21619.1; -; mRNA.
DR EMBL; AC012375; AAF24960.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE30869.1; -; Genomic_DNA.
DR PIR; A86402; A86402.
DR RefSeq; NP_174093.3; NM_102537.3.
DR AlphaFoldDB; Q6SJR1; -.
DR SMR; Q6SJR1; -.
DR BioGRID; 24900; 9.
DR IntAct; Q6SJR1; 9.
DR STRING; 3702.AT1G27720.1; -.
DR iPTMnet; Q6SJR1; -.
DR PaxDb; Q6SJR1; -.
DR PRIDE; Q6SJR1; -.
DR ProteomicsDB; 233009; -.
DR EnsemblPlants; AT1G27720.1; AT1G27720.1; AT1G27720.
DR GeneID; 839665; -.
DR Gramene; AT1G27720.1; AT1G27720.1; AT1G27720.
DR KEGG; ath:AT1G27720; -.
DR Araport; AT1G27720; -.
DR TAIR; locus:2199206; AT1G27720.
DR eggNOG; KOG2341; Eukaryota.
DR HOGENOM; CLU_011622_1_0_1; -.
DR OMA; PINPAPC; -.
DR OrthoDB; 409323at2759; -.
DR PhylomeDB; Q6SJR1; -.
DR PRO; PR:Q6SJR1; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q6SJR1; baseline and differential.
DR Genevisible; Q6SJR1; AT.
DR GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR GO; GO:0005669; C:transcription factor TFIID complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IBA:GO_Central.
DR CDD; cd08045; TAF4; 1.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR022003; RST.
DR InterPro; IPR045144; TAF4.
DR InterPro; IPR007900; TAF4_C.
DR PANTHER; PTHR15138; PTHR15138; 2.
DR Pfam; PF12174; RST; 1.
DR Pfam; PF05236; TAF4; 1.
DR PROSITE; PS51879; RST; 1.
PE 1: Evidence at protein level;
KW Activator; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..720
FT /note="Transcription initiation factor TFIID subunit 4"
FT /id="PRO_0000424040"
FT DOMAIN 79..149
FT /note="RST"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01227"
FT REGION 149..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 654..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 659..677
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 720 AA; 80641 MW; D91383D8A2B5FECF CRC64;
MDLSIVKLLE EDEEVDSKHS EDDLQMFQDS LIRDIEGSNL KSINNTTGNE SEKPQPRYMK
LQKMSSKETP WVEKTVDPVN HNLRLARVTD LLRTVVDHQP GKKTHCLNLH YKLKRKELTM
EEFMRQLRDL VGDQIIRSVI SQLPQLKPGN MGIKVPGRSN HDKVSKSAEF TAQESDPREV
HVNQLSSTTS GTLNSSTTVQ GLNKHPEQHM QLPSSSFHMD TKSGSLNPYP GTNVTSPGSS
SRAKLPDFQH RENNQNVGIA SVGGPTKSTI NMTTVPKFER PTFVNGPSRV QDGPISDFPK
NSSFPLYSAP WQGSVTKDHT VGPSSSVIHV EHKLIDQSFE QAHKPRYLVQ QGVTNVPLKQ
KNAIPISSND DLEKQSSKMG LFTSTTSASS VFPSMTTQLD SSTMVNMPAP SETIPKIANV
TVTPKMPSVG QKKPLEALGS SLPPSRKKQK ICGTSSDESI EKFNDVTAVS GINLREEEKQ
LLDSGPKKND RVSKAYRRLV HGEEERTLLQ KIPLQRKLTE IMGKSGLKHI DHDVERCLSL
CVEERMRGLL FNIIRISKQR TDAEKCRNRT FITSDIRKEI NEMNQKVKEE WEKKHSGEEK
NKENDTEKED QRSNEVKANK KDEDKERAKA ANVAVRAAVG GDDRFSKWKL MAEARQRSSP
GPGRNSKKLS GGTQFGKNQG LPKVVRSISV KDVIAVVEKE PQMSRSTLLY RVYNRICSDV
