ID   TAF4_ASHGO              Reviewed;         361 AA.
AC   Q75CC5;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Transcription initiation factor TFIID subunit 4;
DE   AltName: Full=TBP-associated factor 4;
GN   Name=TAF4; OrderedLocusNames=ACL016C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Functions as a component of the DNA-binding general
CC       transcription factor complex TFIID. Binding of TFIID to a promoter
CC       (with or without TATA element) is the initial step in pre-initiation
CC       complex (PIC) formation. TFIID plays a key role in the regulation of
CC       gene expression by RNA polymerase II through different activities such
CC       as transcription activator interaction, core promoter recognition and
CC       selectivity, TFIIA and TFIIB interaction, chromatin modification
CC       (histone acetylation by TAF1), facilitation of DNA opening and
CC       initiation of transcription (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The 1.2 MDa TFIID complex is composed of TATA binding protein
CC       (TBP) and the 14 TBP-associated factors. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TAF4 family. {ECO:0000305}.
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DR   EMBL; AE016816; AAS51212.1; -; Genomic_DNA.
DR   RefSeq; NP_983388.1; NM_208741.1.
DR   AlphaFoldDB; Q75CC5; -.
DR   STRING; 33169.AAS51212; -.
DR   EnsemblFungi; AAS51212; AAS51212; AGOS_ACL016C.
DR   GeneID; 4619513; -.
DR   KEGG; ago:AGOS_ACL016C; -.
DR   eggNOG; KOG2341; Eukaryota.
DR   HOGENOM; CLU_036634_0_0_1; -.
DR   InParanoid; Q75CC5; -.
DR   OMA; YGWLTSS; -.
DR   Proteomes; UP000000591; Chromosome III.
DR   GO; GO:0005669; C:transcription factor TFIID complex; IBA:GO_Central.
DR   GO; GO:0003682; F:chromatin binding; IEA:EnsemblFungi.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:EnsemblFungi.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR   GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IBA:GO_Central.
DR   CDD; cd08045; TAF4; 1.
DR   InterPro; IPR045144; TAF4.
DR   InterPro; IPR007900; TAF4_C.
DR   PANTHER; PTHR15138; PTHR15138; 1.
DR   Pfam; PF05236; TAF4; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..361
FT                   /note="Transcription initiation factor TFIID subunit 4"
FT                   /id="PRO_0000343436"
FT   DOMAIN          166..234
FT                   /note="Histone-fold"
FT   REGION          1..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..68
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   361 AA;  38973 MW;  033C4C780FA7337E CRC64;
     MGKSPKAADQ GDTGAGGKKT KGEDGFSFGI DAEEVEPTGS DFSNDMPTPF DNFVGQDEQS
     NRAELPESGQ PATTLALPAG GAGSGAGRKS PQKMQRAGMR RAAGAGAPKQ QSDPDKLSDA
     LLSAGVDIKE EEALLSSTVT TMKSNSQVSN SQIPLHPPFL HPSHVASMMK KVAAEQNFNQ
     DFSKSSELLS LMSTACELYI RDIITNSIII SRHRRKAVKL NSGRRSETTR VLRDLALKQR
     EQEERRVKRR IALGLEKEIT DTKLDSGETL HRASNATANM MIAGGKKKYS WLTSGSKVNA
     TDLKNPGKVS SAVAARGDLG IKFREAREEP GIVMRDLLHA LENRRVGVNN TIAKGYARIR
     D