BPIB3_MOUSE
ID BPIB3_MOUSE Reviewed; 473 AA.
AC Q80ZU7; A2APD1;
DT 29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=BPI fold-containing family B member 3 {ECO:0000305};
DE AltName: Full=Ligand-binding protein RYA3;
DE AltName: Full=Long palate, lung and nasal epithelium carcinoma-associated protein 3;
DE Flags: Precursor;
GN Name=Bpifb3 {ECO:0000312|MGI:MGI:2675077}; Synonyms=Lplunc3, Rya3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May have the capacity to recognize and bind specific classes
CC of odorants. May act as a carrier molecule, transporting odorants
CC across the mucus layer to access receptor sites. May serve as a primary
CC defense mechanism by recognizing and removing potentially harmful
CC odorants or pathogenic microorganisms from the mucosa or clearing
CC excess odorant from mucus to enable new odorant stimuli to be received
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
CC {ECO:0000305}.
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DR EMBL; AL833803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC048084; AAH48084.2; -; mRNA.
DR CCDS; CCDS16921.1; -.
DR RefSeq; NP_919338.2; NM_194357.1.
DR RefSeq; XP_006499875.1; XM_006499812.1.
DR AlphaFoldDB; Q80ZU7; -.
DR SMR; Q80ZU7; -.
DR STRING; 10090.ENSMUSP00000086342; -.
DR GlyGen; Q80ZU7; 1 site.
DR PhosphoSitePlus; Q80ZU7; -.
DR PaxDb; Q80ZU7; -.
DR PRIDE; Q80ZU7; -.
DR ProteomicsDB; 281703; -.
DR Antibodypedia; 59271; 65 antibodies from 16 providers.
DR DNASU; 378700; -.
DR Ensembl; ENSMUST00000088950; ENSMUSP00000086342; ENSMUSG00000068008.
DR Ensembl; ENSMUST00000109760; ENSMUSP00000105382; ENSMUSG00000068008.
DR GeneID; 378700; -.
DR KEGG; mmu:378700; -.
DR UCSC; uc008nip.1; mouse.
DR CTD; 359710; -.
DR MGI; MGI:2675077; Bpifb3.
DR VEuPathDB; HostDB:ENSMUSG00000068008; -.
DR eggNOG; KOG4160; Eukaryota.
DR GeneTree; ENSGT01020000230460; -.
DR HOGENOM; CLU_031635_1_0_1; -.
DR InParanoid; Q80ZU7; -.
DR OMA; EWLSHVV; -.
DR OrthoDB; 1099604at2759; -.
DR PhylomeDB; Q80ZU7; -.
DR TreeFam; TF315617; -.
DR BioGRID-ORCS; 378700; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Bpifb3; mouse.
DR PRO; PR:Q80ZU7; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q80ZU7; protein.
DR Bgee; ENSMUSG00000068008; Expressed in olfactory epithelium and 15 other tissues.
DR Genevisible; Q80ZU7; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR InterPro; IPR032951; BPIFB3.
DR InterPro; IPR001124; Lipid-bd_serum_glycop_C.
DR InterPro; IPR017942; Lipid-bd_serum_glycop_N.
DR PANTHER; PTHR46019:SF5; PTHR46019:SF5; 1.
DR Pfam; PF01273; LBP_BPI_CETP; 1.
DR Pfam; PF02886; LBP_BPI_CETP_C; 1.
DR SMART; SM00328; BPI1; 1.
DR SMART; SM00329; BPI2; 1.
DR SUPFAM; SSF55394; SSF55394; 2.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..473
FT /note="BPI fold-containing family B member 3"
FT /id="PRO_0000017171"
FT CARBOHYD 139
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 161..196
FT /evidence="ECO:0000250"
SQ SEQUENCE 473 AA; 49885 MW; 246BF7BAEB328913 CRC64;
MMLGVYTLLL LWGLATPCLG LLETVGTLAR IDKDELGKAI QNSLVGGPIL QNVLGTVTSV
NQGLLGAGGL LGGGGLLSYG GIFSLVEELS GLKIEELTLP KVSLKLLPGV GVQLNLHTKV
SLHGSGPLVG LLQLAAEVNV SSKVALGMSP RGTPILVLKR CSTLLGHISL MSGLLPTPIF
GLVEQTLCKV LPGLLCPVVD SVLSVVNELL GATLSLVPLG PLGSVEFTLA TLPLISNQYI
ELDINPIVKS IAGDVIDFPK PRIPVKVPPK EDHTSQVTVP LYLFSTVFGL LQTNGALDLD
ITPEMVPRNV PLTTTDLAAL APEALGKLPP AQHLLLSLRV TKSPMVLLQN KKATVSIPVT
IHVLSSVPQG TPVALFQLNG VMTLNAHLAP SSTKLHISLS LERLSVQLAS SFPQPFDASR
LEEWLSDVVR AAYMQRLNEH LEVGIPLPKI LNVNFANSVV DIIENAVVLT VAP
