ID   TAF4_CANAL              Reviewed;         363 AA.
AC   Q59U67; A0A1D8PHX9;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2017, sequence version 2.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Transcription initiation factor TFIID subunit 4;
DE   AltName: Full=TBP-associated factor 4;
GN   Name=TAF4; OrderedLocusNames=CAALFM_C207460WA;
GN   ORFNames=CaO19.1885, CaO19.9441;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Functions as a component of the DNA-binding general
CC       transcription factor complex TFIID. Binding of TFIID to a promoter
CC       (with or without TATA element) is the initial step in pre-initiation
CC       complex (PIC) formation. TFIID plays a key role in the regulation of
CC       gene expression by RNA polymerase II through different activities such
CC       as transcription activator interaction, core promoter recognition and
CC       selectivity, TFIIA and TFIIB interaction, chromatin modification
CC       (histone acetylation by TAF1), facilitation of DNA opening and
CC       initiation of transcription (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The 1.2 MDa TFIID complex is composed of TATA binding protein
CC       (TBP) and the 14 TBP-associated factors. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TAF4 family. {ECO:0000305}.
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DR   EMBL; CP017624; AOW27744.1; -; Genomic_DNA.
DR   RefSeq; XP_713142.2; XM_708049.2.
DR   AlphaFoldDB; Q59U67; -.
DR   STRING; 237561.Q59U67; -.
DR   GeneID; 3645198; -.
DR   KEGG; cal:CAALFM_C207460WA; -.
DR   CGD; CAL0000193600; TAF4.
DR   VEuPathDB; FungiDB:C2_07460W_A; -.
DR   eggNOG; KOG2341; Eukaryota.
DR   HOGENOM; CLU_036634_1_0_1; -.
DR   InParanoid; Q59U67; -.
DR   OrthoDB; 1315539at2759; -.
DR   PRO; PR:Q59U67; -.
DR   Proteomes; UP000000559; Chromosome 2.
DR   GO; GO:0005669; C:transcription factor TFIID complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IBA:GO_Central.
DR   CDD; cd08045; TAF4; 1.
DR   InterPro; IPR045144; TAF4.
DR   InterPro; IPR007900; TAF4_C.
DR   PANTHER; PTHR15138; PTHR15138; 1.
DR   Pfam; PF05236; TAF4; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..363
FT                   /note="Transcription initiation factor TFIID subunit 4"
FT                   /id="PRO_0000343437"
FT   DOMAIN          141..216
FT                   /note="Histone-fold"
FT   REGION          1..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          230..259
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          292..318
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          207..232
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..18
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        27..75
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        292..311
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   363 AA;  39591 MW;  03261DA6142CA007 CRC64;
     MTSTPQESSN LKRQLENSED SSSPNKKSKT ETTTENQSSW ESDFNSLPVE LLQTETNGTS
     PAPAPATPID TTNVSNSKER DQDTSKLNDA IAAAGVDIQQ EEEILLQQQL NRKSAEGMAS
     NLKSVIRSSK SPPFLHNYHL AAFIDKVAKQ NGIQQNFLMD GEMLELISAA CETWLSNLAT
     KTIILSRHRR RGIPVINKKS GSSSVPRSEI SKELRSLALK QKEMEEKRVN KRVMLGLEKS
     TKDASKNDEN GESKAGAEET LHRAANATAA MMTMNPGRKK YSWMTSSATA GGGSDFGKSS
     GGSSKDSGKH QSPIISVRGD NGLRFREIRS GNSIIMKDLL GAIEDEKMGT RNAVIKGYAK
     LKD