ID   TAF4_VANPO              Reviewed;         421 AA.
AC   A7TJV5;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Transcription initiation factor TFIID subunit 4;
DE   AltName: Full=TBP-associated factor 4;
GN   Name=TAF4; ORFNames=Kpol_1037p13;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Functions as a component of the DNA-binding general
CC       transcription factor complex TFIID. Binding of TFIID to a promoter
CC       (with or without TATA element) is the initial step in pre-initiation
CC       complex (PIC) formation. TFIID plays a key role in the regulation of
CC       gene expression by RNA polymerase II through different activities such
CC       as transcription activator interaction, core promoter recognition and
CC       selectivity, TFIIA and TFIIB interaction, chromatin modification
CC       (histone acetylation by TAF1), facilitation of DNA opening and
CC       initiation of transcription (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The 1.2 MDa TFIID complex is composed of TATA binding protein
CC       (TBP) and the 14 TBP-associated factors. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the TAF4 family. {ECO:0000305}.
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DR   EMBL; DS480404; EDO17417.1; -; Genomic_DNA.
DR   RefSeq; XP_001645275.1; XM_001645225.1.
DR   AlphaFoldDB; A7TJV5; -.
DR   STRING; 436907.A7TJV5; -.
DR   EnsemblFungi; EDO17417; EDO17417; Kpol_1037p13.
DR   GeneID; 5545634; -.
DR   KEGG; vpo:Kpol_1037p13; -.
DR   eggNOG; KOG2341; Eukaryota.
DR   HOGENOM; CLU_036634_0_0_1; -.
DR   InParanoid; A7TJV5; -.
DR   OMA; YGWLTSS; -.
DR   OrthoDB; 1315539at2759; -.
DR   PhylomeDB; A7TJV5; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0005669; C:transcription factor TFIID complex; IEA:InterPro.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR   CDD; cd08045; TAF4; 1.
DR   InterPro; IPR045144; TAF4.
DR   InterPro; IPR007900; TAF4_C.
DR   PANTHER; PTHR15138; PTHR15138; 1.
DR   Pfam; PF05236; TAF4; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..421
FT                   /note="Transcription initiation factor TFIID subunit 4"
FT                   /id="PRO_0000343444"
FT   DOMAIN          226..294
FT                   /note="Histone-fold"
FT   REGION          1..176
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..54
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        65..117
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        141..155
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   421 AA;  45409 MW;  EA0F7B74AC020F38 CRC64;
     MSGTLSSNNN GIDTKNDNEN VSGNVNGNEN QTENQNQNQN ENENGTGNES SNEPPMKKIK
     TESGLDDSNP TFDFGITTDS SSQNIENSKS TPSEFTSDST SAFDSAVKNS DGLSLPKSVA
     PSTDLKKDAI PTSNSGLALP KKNEKKGKTT GGKNVNKKES GKPGAKGSQS QTDASKMSDV
     LFSAGVDIRE EEALLTSSVA ASKTQSQPAA VNIPEHPPFL HPDQVAAFMK KASKEQNFNQ
     NFAKQGEILQ MISSSCENYM RDIITNTIVI SRHRRKAVKV NSGRRSEVAI ALKSIAIQQK
     KDEERRVKKR IALGLEKEDT ENKIDSEETL HRASNATAGL RAGSKKQYGW LTSSTNKPLA
     ATGKGAGNIA AAIAARGDTG LRFREAREEP GIVMRDLLNA LENRRIGSHN IITKGYARIR
     D