TAF5_ENCCU
ID TAF5_ENCCU Reviewed; 556 AA.
AC Q8SQS4;
DT 01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 25-MAY-2022, entry version 125.
DE RecName: Full=Transcription initiation factor TFIID subunit 5;
GN Name=TAF5; OrderedLocusNames=ECU11_1750;
OS Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC Encephalitozoon.
OX NCBI_TaxID=284813;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GB-M1;
RX PubMed=11719806; DOI=10.1038/35106579;
RA Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA Vivares C.P.;
RT "Genome sequence and gene compaction of the eukaryote parasite
RT Encephalitozoon cuniculi.";
RL Nature 414:450-453(2001).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 16-149.
RX PubMed=17397863; DOI=10.1016/j.jmb.2007.02.039;
RA Romier C., James N., Birck C., Cavarelli J., Vivares C.P., Collart M.A.,
RA Moras D.;
RT "Crystal structure, biochemical and genetic characterization of yeast and
RT E. cuniculi TAF(II)5 N-terminal domain: implications for TFIID assembly.";
RL J. Mol. Biol. 368:1292-1306(2007).
CC -!- FUNCTION: TAFs are components of the transcription factor IID (TFIID)
CC complex that are essential for mediating regulation of RNA polymerase
CC transcription. Regulates the genes involved in ubiquitin-dependent
CC proteolysis during the progression of M-phase of mitosis (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the TFIID and SAGA complexes. TFIID is composed
CC of TATA binding protein (TBP) and a number of TBP-associated factors
CC (TAFs) (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat TAF5 family. {ECO:0000305}.
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DR EMBL; AL590450; CAD26085.1; -; Genomic_DNA.
DR RefSeq; NP_586481.1; NM_001042314.1.
DR PDB; 2J4B; X-ray; 2.50 A; A/B/C/D/E=16-149.
DR PDBsum; 2J4B; -.
DR AlphaFoldDB; Q8SQS4; -.
DR SMR; Q8SQS4; -.
DR STRING; 284813.Q8SQS4; -.
DR GeneID; 860135; -.
DR KEGG; ecu:ECU11_1750; -.
DR VEuPathDB; MicrosporidiaDB:ECU11_1750; -.
DR HOGENOM; CLU_005884_2_1_1; -.
DR InParanoid; Q8SQS4; -.
DR OMA; RPHQADV; -.
DR OrthoDB; 620721at2759; -.
DR EvolutionaryTrace; Q8SQS4; -.
DR Proteomes; UP000000819; Chromosome XI.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR CDD; cd08044; TAF5_NTD2; 1.
DR Gene3D; 1.25.40.500; -; 1.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR037783; Taf5.
DR InterPro; IPR007582; TFIID_NTD2.
DR InterPro; IPR037264; TFIID_NTD2_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR19879; PTHR19879; 1.
DR Pfam; PF04494; TFIID_NTD2; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF160897; SSF160897; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; WD repeat.
FT CHAIN 1..556
FT /note="Transcription initiation factor TFIID subunit 5"
FT /id="PRO_0000383042"
FT REPEAT 251..291
FT /note="WD 1"
FT REPEAT 320..359
FT /note="WD 2"
FT REPEAT 362..401
FT /note="WD 3"
FT REPEAT 404..443
FT /note="WD 4"
FT REPEAT 446..485
FT /note="WD 5"
FT REPEAT 488..527
FT /note="WD 6"
FT HELIX 19..32
FT /evidence="ECO:0007829|PDB:2J4B"
FT HELIX 35..41
FT /evidence="ECO:0007829|PDB:2J4B"
FT HELIX 42..44
FT /evidence="ECO:0007829|PDB:2J4B"
FT HELIX 45..58
FT /evidence="ECO:0007829|PDB:2J4B"
FT HELIX 62..72
FT /evidence="ECO:0007829|PDB:2J4B"
FT HELIX 73..75
FT /evidence="ECO:0007829|PDB:2J4B"
FT HELIX 80..86
FT /evidence="ECO:0007829|PDB:2J4B"
FT HELIX 92..97
FT /evidence="ECO:0007829|PDB:2J4B"
FT HELIX 99..106
FT /evidence="ECO:0007829|PDB:2J4B"
FT STRAND 109..114
FT /evidence="ECO:0007829|PDB:2J4B"
FT HELIX 115..127
FT /evidence="ECO:0007829|PDB:2J4B"
FT HELIX 131..140
FT /evidence="ECO:0007829|PDB:2J4B"
FT STRAND 141..146
FT /evidence="ECO:0007829|PDB:2J4B"
SQ SEQUENCE 556 AA; 63347 MW; 58DC2FEF23C0EA5C CRC64;
MSENIRESIS AKTLSKDQME TSYVSLKTWI EDSLDLFKND LLPLLYPLFI HIYFDLIQQN
KTDEAKEFFE KYRGDHYNKS EEIKQFESIY TVQHIHENNF AYTFKNSKYH LSMGRYAFDL
LINFLEERNL TYILKILNQH LDIKVYVGPK SEERPQGIET SVVDAEIDLT TFLVSRECED
AILGDEQYRY DHLETYVLQL RKQREMKPKD SVYKPNASQI HAEIEKLKDL CKRVAVNKNN
LPSICCYTIH NTYEGLTAAE ISNDLKLMAC GFKDSYVEVY SLTNESLKKL KSSSELAKSD
IKTLNEEKFE EVGSSYKLVG HSGPVYGLKF FSSNKFLVSS SQDCTVCLWS LDLLCLLAVY
KAHAFPVWCV DVAPNDYFFA SGAGDRQAIV WSVMTSKPER LIISSLSDVT AVKFHPNSSY
LFTGSSDHRV RMHDISTASV VRIFCGHTDT VTCMDVSHCG KFLASGSKDR TVLLWDIQSS
KLLGKYVGHE NTVFSVSFCF YGSVLASCGA DNSVRLWDRT DHKGGCLGTY YTKNTPLLCV
KFGYRNIISC TGPFIS
