ID   BPIB4_HUMAN             Reviewed;         614 AA.
AC   P59827; Q5TDX6;
DT   29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 2.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=BPI fold-containing family B member 4;
DE   AltName: Full=Ligand-binding protein RY2G5;
DE   AltName: Full=Long palate, lung and nasal epithelium carcinoma-associated protein 4;
DE   Flags: Precursor;
GN   Name=BPIFB4; Synonyms=C20orf186, LPLUNC4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND SUBCELLULAR LOCATION.
RC   TISSUE=Fetal brain;
RX   PubMed=12837268; DOI=10.1016/s0888-7543(03)00102-2;
RA   Andrault J.-B., Gaillard I., Giorgi D., Rouquier S.;
RT   "Expansion of the BPI family by duplication on human chromosome 20:
RT   characterization of the RY gene cluster in 20q11.21 encoding olfactory
RT   transporters/antimicrobial-like peptides.";
RL   Genomics 82:172-184(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA   Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA   Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA   Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA   Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA   Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA   Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA   Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA   Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA   Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA   Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [3]
RP   IDENTIFICATION, AND TISSUE SPECIFICITY.
RX   PubMed=11971875; DOI=10.1093/hmg/11.8.937;
RA   Bingle C.D., Craven C.J.;
RT   "PLUNC: a novel family of candidate host defence proteins expressed in the
RT   upper airways and nasopharynx.";
RL   Hum. Mol. Genet. 11:937-943(2002).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=14739326; DOI=10.1110/ps.03332704;
RA   Bingle C.D., LeClair E.E., Havard S., Bingle L., Gillingham P.,
RA   Craven C.J.;
RT   "Phylogenetic and evolutionary analysis of the PLUNC gene family.";
RL   Protein Sci. 13:422-430(2004).
CC   -!- FUNCTION: May have the capacity to recognize and bind specific classes
CC       of odorants. May act as a carrier molecule, transporting odorants
CC       across the mucus layer to access receptor sites. May serve as a primary
CC       defense mechanism by recognizing and removing potentially harmful
CC       odorants or pathogenic microorganisms from the mucosa or clearing
CC       excess odorant from mucus to enable new odorant stimuli to be received
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Cytoplasm
CC       {ECO:0000269|PubMed:12837268}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P59827-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P59827-2; Sequence=VSP_037828;
CC   -!- TISSUE SPECIFICITY: Expressed in nasal tissue.
CC       {ECO:0000269|PubMed:11971875}.
CC   -!- SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
CC       {ECO:0000305}.
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DR   EMBL; AF549190; AAP84990.1; -; mRNA.
DR   EMBL; AL121756; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS13213.2; -. [P59827-1]
DR   RefSeq; NP_872325.2; NM_182519.2. [P59827-1]
DR   AlphaFoldDB; P59827; -.
DR   SMR; P59827; -.
DR   BioGRID; 127251; 1.
DR   STRING; 9606.ENSP00000364632; -.
DR   GlyGen; P59827; 1 site.
DR   iPTMnet; P59827; -.
DR   PhosphoSitePlus; P59827; -.
DR   BioMuta; BPIFB4; -.
DR   DMDM; 215274098; -.
DR   MassIVE; P59827; -.
DR   PaxDb; P59827; -.
DR   PeptideAtlas; P59827; -.
DR   PRIDE; P59827; -.
DR   ProteomicsDB; 57163; -. [P59827-1]
DR   ProteomicsDB; 57164; -. [P59827-2]
DR   Antibodypedia; 25501; 12 antibodies from 8 providers.
DR   DNASU; 149954; -.
DR   Ensembl; ENST00000375483.4; ENSP00000364632.3; ENSG00000186191.9. [P59827-1]
DR   GeneID; 149954; -.
DR   KEGG; hsa:149954; -.
DR   MANE-Select; ENST00000375483.4; ENSP00000364632.3; NM_182519.3; NP_872325.2.
DR   UCSC; uc010zue.3; human. [P59827-1]
DR   CTD; 149954; -.
DR   DisGeNET; 149954; -.
DR   GeneCards; BPIFB4; -.
DR   HGNC; HGNC:16179; BPIFB4.
DR   HPA; ENSG00000186191; Tissue enriched (pituitary).
DR   MIM; 615718; gene.
DR   neXtProt; NX_P59827; -.
DR   OpenTargets; ENSG00000186191; -.
DR   PharmGKB; PA25728; -.
DR   VEuPathDB; HostDB:ENSG00000186191; -.
DR   eggNOG; KOG4160; Eukaryota.
DR   GeneTree; ENSGT01020000230460; -.
DR   HOGENOM; CLU_031635_0_0_1; -.
DR   InParanoid; P59827; -.
DR   OrthoDB; 1099604at2759; -.
DR   PhylomeDB; P59827; -.
DR   TreeFam; TF315617; -.
DR   PathwayCommons; P59827; -.
DR   Reactome; R-HSA-6803157; Antimicrobial peptides.
DR   BioGRID-ORCS; 149954; 15 hits in 1071 CRISPR screens.
DR   GenomeRNAi; 149954; -.
DR   Pharos; P59827; Tbio.
DR   PRO; PR:P59827; -.
DR   Proteomes; UP000005640; Chromosome 20.
DR   RNAct; P59827; protein.
DR   Bgee; ENSG00000186191; Expressed in olfactory segment of nasal mucosa and 55 other tissues.
DR   ExpressionAtlas; P59827; baseline and differential.
DR   Genevisible; P59827; HS.
DR   GO; GO:0015629; C:actin cytoskeleton; IDA:HPA.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR   InterPro; IPR001124; Lipid-bd_serum_glycop_C.
DR   InterPro; IPR017942; Lipid-bd_serum_glycop_N.
DR   Pfam; PF01273; LBP_BPI_CETP; 1.
DR   Pfam; PF02886; LBP_BPI_CETP_C; 1.
DR   SMART; SM00328; BPI1; 1.
DR   SMART; SM00329; BPI2; 1.
DR   SUPFAM; SSF55394; SSF55394; 2.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cytoplasm; Disulfide bond; Glycoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..614
FT                   /note="BPI fold-containing family B member 4"
FT                   /id="PRO_0000089159"
FT   CARBOHYD        273
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        295..332
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         1..39
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:12837268"
FT                   /id="VSP_037828"
FT   VARIANT         167
FT                   /note="G -> W (in dbSNP:rs2424943)"
FT                   /id="VAR_059372"
FT   VARIANT         199
FT                   /note="D -> G (in dbSNP:rs4339026)"
FT                   /id="VAR_055998"
FT   VARIANT         206
FT                   /note="G -> W (in dbSNP:rs2424943)"
FT                   /id="VAR_055999"
FT   VARIANT         229
FT                   /note="I -> V (in dbSNP:rs2070325)"
FT                   /id="VAR_059373"
FT   VARIANT         268
FT                   /note="I -> V (in dbSNP:rs2070325)"
FT                   /id="VAR_056000"
FT   VARIANT         320
FT                   /note="N -> T (in dbSNP:rs2889732)"
FT                   /id="VAR_056001"
FT   VARIANT         527
FT                   /note="F -> L (in dbSNP:rs11699009)"
FT                   /id="VAR_069042"
FT   VARIANT         533
FT                   /note="T -> I (in dbSNP:rs11696307)"
FT                   /id="VAR_069043"
SQ   SEQUENCE   614 AA;  65055 MW;  F92C542B75CB97E1 CRC64;
     MWMAWCVAAL SVVAVCGTSH ETNTVLRVTK DVLSNAISGM LQQSDALHSA LREVPLGVGD
     IPYNDFHVRG PPPVYTNGKK LDGIYQYGHI ETNDNTAQLG GKYRYGEILE SEGSIRDLRN
     SGYRSAENAY GGHRGLGRYR AAPVGRLHRR ELQPGEIPPG VATGAVGPGG LLGTGGMLAA
     DGILAGQGGL LGGGGLLGDG GLLGGGGVLG VLGEGGILST VQGITGLRIV ELTLPRVSVR
     LLPGVGVYLS LYTRVAINGK SLIGFLDIAV EVNITAKVRL TMDRTGYPRL VIERCDTLLG
     GIKVKLLRGL LPNLVDNLVN RVLADVLPDL LCPIVDVVLG LVNDQLGLVD SLIPLGILGS
     VQYTFSSLPL VTGEFLELDL NTLVGEAGGG LIDYPLGWPA VSPKPMPELP PMGDNTKSQL
     AMSANFLGSV LTLLQKQHAL DLDITNGMFE ELPPLTTATL GALIPKVFQQ YPESCPLIIR
     IQVLNPPSVM LQKDKALVKV LATAEVMVSQ PKDLETTICL IDVDTEFLAS FSTEGDKLMI
     DAKLEKTSLN LRTSNVGNFD IGLMEVLVEK IFDLAFMPAM NAVLGSGVPL PKILNIDFSN
     ADIDVLEDLL VLSA