TAF6B_ARATH
ID TAF6B_ARATH Reviewed; 527 AA.
AC F4HVA6; F4HVA7; F4HVA8; F4HVA9; F4HVB0; Q6S7A0; Q6S7A1; Q6S7A2; Q8W4N6;
AC Q9SLJ8;
DT 16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Transcription initiation factor TFIID subunit 6b;
DE AltName: Full=TBP-associated factor 6b;
DE Short=AtTAF6b;
GN Name=TAF6B; OrderedLocusNames=At1g54360; ORFNames=F20D21.18;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), IDENTIFICATION, NOMENCLATURE, AND
RP TISSUE SPECIFICITY.
RX PubMed=15527982; DOI=10.1016/j.gene.2004.08.023;
RA Lago C., Clerici E., Mizzi L., Colombo L., Kater M.M.;
RT "TBP-associated factors in Arabidopsis.";
RL Gene 342:231-241(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 6), AND INTERACTION WITH TAF5
RP AND TAF9.
RC STRAIN=cv. Columbia;
RX PubMed=17340043; DOI=10.1007/s11103-007-9135-1;
RA Lawit S.J., O'Grady K., Gurley W.B., Czarnecka-Verner E.;
RT "Yeast two-hybrid map of Arabidopsis TFIID.";
RL Plant Mol. Biol. 64:73-87(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 23-527 (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [6]
RP FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=cv. Wassilewskija;
RX PubMed=16039640; DOI=10.1016/j.ydbio.2005.06.006;
RA Lago C., Clerici E., Dreni L., Horlow C., Caporali E., Colombo L.,
RA Kater M.M.;
RT "The Arabidopsis TFIID factor AtTAF6 controls pollen tube growth.";
RL Dev. Biol. 285:91-100(2005).
CC -!- FUNCTION: TAFs are components of the transcription factor IID (TFIID)
CC complex that is essential for mediating regulation of RNA polymerase
CC transcription. Not redundant with TAF6. {ECO:0000269|PubMed:16039640}.
CC -!- SUBUNIT: Component of the TFIID complex. TFIID is composed of TATA
CC binding protein (TBP) and a number of TBP-associated factors (TAFs)
CC whose MWs range from 14-217 kDa. Interacts with TAF5 and TAF9.
CC {ECO:0000269|PubMed:17340043}.
CC -!- INTERACTION:
CC F4HVA6; O04173: TAF10; NbExp=3; IntAct=EBI-1245557, EBI-1247479;
CC F4HVA6; Q6S7B0: TAF5; NbExp=3; IntAct=EBI-1245557, EBI-1247501;
CC F4HVA6; Q9SYH2: TAF9; NbExp=4; IntAct=EBI-1245557, EBI-1247576;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=F4HVA6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=F4HVA6-2; Sequence=VSP_053304;
CC Name=3;
CC IsoId=F4HVA6-3; Sequence=VSP_053304, VSP_053305;
CC Name=4;
CC IsoId=F4HVA6-4; Sequence=VSP_053303;
CC Name=5;
CC IsoId=F4HVA6-5; Sequence=VSP_053301;
CC Name=6;
CC IsoId=F4HVA6-6; Sequence=VSP_053302;
CC -!- TISSUE SPECIFICITY: Expressed in roots, leaves, inflorescences and
CC siliques. {ECO:0000269|PubMed:15527982, ECO:0000269|PubMed:16039640}.
CC -!- DEVELOPMENTAL STAGE: Not expressed in germinating pollen.
CC {ECO:0000269|PubMed:16039640}.
CC -!- SIMILARITY: Belongs to the TAF6 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD25616.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAL32535.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY463630; AAS17938.1; -; mRNA.
DR EMBL; AY463631; AAS17939.1; -; mRNA.
DR EMBL; AY463632; AAS17940.1; -; mRNA.
DR EMBL; AC005287; AAD25616.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE33085.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE33086.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE33088.1; -; Genomic_DNA.
DR EMBL; AY062457; AAL32535.1; ALT_INIT; mRNA.
DR EMBL; BT003362; AAO29980.1; -; mRNA.
DR PIR; C96585; C96585.
DR RefSeq; NP_001031187.2; NM_001036110.1. [F4HVA6-3]
DR RefSeq; NP_001185221.1; NM_001198292.1. [F4HVA6-4]
DR RefSeq; NP_974024.2; NM_202295.2. [F4HVA6-1]
DR AlphaFoldDB; F4HVA6; -.
DR SMR; F4HVA6; -.
DR BioGRID; 27102; 43.
DR IntAct; F4HVA6; 16.
DR STRING; 3702.AT1G54360.2; -.
DR PaxDb; F4HVA6; -.
DR PRIDE; F4HVA6; -.
DR ProteomicsDB; 234131; -. [F4HVA6-1]
DR GeneID; 841877; -.
DR KEGG; ath:AT1G54360; -.
DR Araport; AT1G54360; -.
DR TAIR; locus:2020143; AT1G54360.
DR eggNOG; KOG2549; Eukaryota.
DR HOGENOM; CLU_541420_0_0_1; -.
DR InParanoid; F4HVA6; -.
DR PRO; PR:F4HVA6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4HVA6; baseline and differential.
DR Genevisible; F4HVA6; AT.
DR GO; GO:0000124; C:SAGA complex; IEA:InterPro.
DR GO; GO:0046695; C:SLIK (SAGA-like) complex; IEA:InterPro.
DR GO; GO:0005669; C:transcription factor TFIID complex; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IEA:InterPro.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0051123; P:RNA polymerase II preinitiation complex assembly; IBA:GO_Central.
DR CDD; cd08050; TAF6C; 1.
DR Gene3D; 1.10.20.10; -; 1.
DR Gene3D; 1.25.40.770; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR037796; TAF6.
DR InterPro; IPR011442; TAF6_C.
DR InterPro; IPR046344; TAF6_C_sf.
DR InterPro; IPR004823; TAF_TATA-bd_Histone-like_dom.
DR PANTHER; PTHR10221; PTHR10221; 1.
DR Pfam; PF02969; TAF; 2.
DR Pfam; PF07571; TAF6_C; 1.
DR SMART; SM00803; TAF; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Activator; Alternative splicing; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..527
FT /note="Transcription initiation factor TFIID subunit 6b"
FT /id="PRO_0000424043"
FT DOMAIN 3..99
FT /note="Histone-fold"
FT REGION 410..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 462..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..441
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..99
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000305"
FT /id="VSP_053301"
FT VAR_SEQ 30..80
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:17340043"
FT /id="VSP_053302"
FT VAR_SEQ 33..83
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000305"
FT /id="VSP_053303"
FT VAR_SEQ 40..62
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14593172,
FT ECO:0000303|PubMed:15527982, ECO:0000303|PubMed:17340043"
FT /id="VSP_053304"
FT VAR_SEQ 178..184
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17340043"
FT /id="VSP_053305"
FT CONFLICT 140
FT /note="L -> S (in Ref. 2; AAS17938/AAS17939/AAS17940 and 5;
FT AAL32535/AAO29980)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 527 AA; 59275 MW; 06E05ABDD0EAF204 CRC64;
MVTKESIEVI AQSIGLSTLS PDVSAALAPD VEYRVREVMQ VYHQLQLYFC PLISSLTCRR
NLQEAIKCMR HARRTTLMAH DVDSALHFRN LEPTSGSKSM RFKRAPENRD LYFFDDKDVE
LKNVIEAPLP NAPPDASVFL HWLAIDGIQP SIPQNSPLQA ISDLKRSEYK DDGLAARQVL
SKDLQIYFDK VTEWALTQSG STLFRQALAS LEIDPGLHPL VPFFTSFIAE EIVKNMDNYP
ILLALMRLAR SLLHNPHVHI EPYLHQLMPS IITCLIAKRL GRRSSDNHWD LRNFTASTVA
STCKRFGHVY HNLLPRVTRS LLHTFLDPTK ALPQHYGAIQ GMVALGLNMV RFLVLPNLGP
YLLLLLPEMG LEKQKEEAKR HGAWLVYGAL MVAAGRCLYE RLKTSETLLS PPTSSVWKTN
GKLTSPRQSK RKASSDNLTH QPPLKKIAVG GIIQMSSTQM QMRGTTTVPQ QSHTDADARH
HNSPSTIAPK TSAAAGTDVD NYLFPLFEYF GESMLMFTPT HELSFFL
