TAF6_SCHPO
ID TAF6_SCHPO Reviewed; 452 AA.
AC O74462;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 143.
DE RecName: Full=Transcription initiation factor TFIID subunit 6 {ECO:0000250|UniProtKB:P53040};
DE AltName: Full=TBP-associated factor 50 kDa {ECO:0000250|UniProtKB:P53040};
DE Short=TAFII-50 {ECO:0000250|UniProtKB:P53040};
DE Short=TAFII50 {ECO:0000250|UniProtKB:P53040};
DE AltName: Full=TBP-associated factor 6 {ECO:0000250|UniProtKB:P53040};
GN Name=taf6 {ECO:0000312|PomBase:SPCC16C4.18c};
GN Synonyms=taf50 {ECO:0000312|EMBL:CAA20756.1}; ORFNames=SPCC16C4.18c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1] {ECO:0000312|EMBL:CAA20756.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2] {ECO:0000305}
RP INTERACTION WITH GCN5; TAF5 AND TAF73, AND DISRUPTION PHENOTYPE.
RX PubMed=11972332; DOI=10.1093/nar/30.9.1952;
RA Mitsuzawa H., Ishihama A.;
RT "Identification of histone H4-like TAF in Schizosaccharomyces pombe as a
RT protein that interacts with WD repeat-containing TAF.";
RL Nucleic Acids Res. 30:1952-1958(2002).
RN [3] {ECO:0000305}
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: TAFs are components of the transcription factor IID (TFIID)
CC complex that are essential for mediating regulation of RNA polymerase
CC transcription. {ECO:0000250}.
CC -!- SUBUNIT: Component of the TFIID and SAGA complexes. TFIID is composed
CC of TATA binding protein (TBP) and a number of TBP-associated factors
CC (TAFs) whose MWs range from 25-150 kDa (By similarity). Interacts with
CC gcn5, taf5 and taf73. {ECO:0000250, ECO:0000269|PubMed:11972332}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}.
CC -!- DISRUPTION PHENOTYPE: Cells lacking taf6 are not viable.
CC {ECO:0000269|PubMed:11972332}.
CC -!- SIMILARITY: Belongs to the TAF6 family. {ECO:0000255}.
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DR EMBL; CU329672; CAA20756.1; -; Genomic_DNA.
DR PIR; T41108; T41108.
DR RefSeq; NP_587928.1; NM_001022919.2.
DR AlphaFoldDB; O74462; -.
DR SMR; O74462; -.
DR BioGRID; 275705; 12.
DR IntAct; O74462; 2.
DR MINT; O74462; -.
DR STRING; 4896.SPCC16C4.18c.1; -.
DR MaxQB; O74462; -.
DR PaxDb; O74462; -.
DR EnsemblFungi; SPCC16C4.18c.1; SPCC16C4.18c.1:pep; SPCC16C4.18c.
DR GeneID; 2539133; -.
DR KEGG; spo:SPCC16C4.18c; -.
DR PomBase; SPCC16C4.18c; taf6.
DR VEuPathDB; FungiDB:SPCC16C4.18c; -.
DR eggNOG; KOG2549; Eukaryota.
DR HOGENOM; CLU_021711_3_0_1; -.
DR InParanoid; O74462; -.
DR OMA; YFVQFIA; -.
DR PhylomeDB; O74462; -.
DR Reactome; R-SPO-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-SPO-6807505; RNA polymerase II transcribes snRNA genes.
DR Reactome; R-SPO-73776; RNA Polymerase II Promoter Escape.
DR Reactome; R-SPO-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR Reactome; R-SPO-75953; RNA Polymerase II Transcription Initiation.
DR Reactome; R-SPO-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR PRO; PR:O74462; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0000785; C:chromatin; IC:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0000124; C:SAGA complex; IDA:PomBase.
DR GO; GO:0005669; C:transcription factor TFIID complex; IDA:PomBase.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; TAS:PomBase.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0051123; P:RNA polymerase II preinitiation complex assembly; IBA:GO_Central.
DR GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; ISO:PomBase.
DR CDD; cd08050; TAF6C; 1.
DR Gene3D; 1.10.20.10; -; 1.
DR Gene3D; 1.25.40.770; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR037796; TAF6.
DR InterPro; IPR011442; TAF6_C.
DR InterPro; IPR046344; TAF6_C_sf.
DR InterPro; IPR004823; TAF_TATA-bd_Histone-like_dom.
DR PANTHER; PTHR10221; PTHR10221; 1.
DR Pfam; PF02969; TAF; 1.
DR Pfam; PF07571; TAF6_C; 1.
DR SMART; SM00803; TAF; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..452
FT /note="Transcription initiation factor TFIID subunit 6"
FT /id="PRO_0000361054"
FT DOMAIN 4..68
FT /note="Histone-fold"
FT /evidence="ECO:0000255"
SQ SEQUENCE 452 AA; 50273 MW; CA3AF8DB81E7AC6D CRC64;
MSLTVWNIES IKDVAEMLGI GNLADEPAAA IAMDLEYRIH QVVQEATKFM VHSKRTVLTS
ADISSALRTL NVEPLYGFNN SRPLEFHEAA VGAGQNSLYY LDDEEVDFEK IINAPLPKVP
RNISYSAHWL AIEGVQPAIP QNPTPSDHTV GEWASKGTSG VMPGASTAAK EARNGVTSMD
NVEIKPLVRH VLSKELQLYF ERITSALLDE TNVELRDAAL SSLRDDPGLH QLLPYFIMFL
SDSVTRNLGN LVVLTTLMHM AWALLDNPNL FVEPYVQQLM PSILTCLVAK RLGSDPNNHE
HYALRDLAAF LLGIVCDRFG NVYYTLKPRV TRTALKAFLD NTKPYSTHYG AIKGLKTMGK
EAIRVLVVPN IKVYEVLVRK TLEKGNEEEI YEANKCMDAL YDALLLLRDD QLPNQRTLPP
NASGLLEKNV GSLMAEKIMK ENDTSLLLGL LE
