TAF6_XENLA
ID TAF6_XENLA Reviewed; 618 AA.
AC Q91857; Q6NU26;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 3.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Transcription initiation factor TFIID subunit 6;
DE Short=xTAF6;
DE AltName: Full=Transcription initiation factor TFIID 60 kDa subunit;
DE Short=TAF(II)60;
DE Short=TAFII-60;
DE Short=TAFII60;
DE AltName: Full=Transcription initiation factor TFIID 70 kDa subunit;
DE Short=TAF(II)70;
DE Short=TAFII-70;
DE Short=TAFII70;
GN Name=taf6;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Oocyte;
RX PubMed=7590360; DOI=10.1016/0378-1119(95)00517-a;
RA Hasegawa S., Kuzuhara T., Horikoshi M.;
RT "The sequence of a Xenopus laevis TFIID subunit reveals remarkable
RT conservation among vertebrates.";
RL Gene 164:369-370(1995).
RN [2]
RP SEQUENCE REVISION.
RA Horikoshi M.;
RL Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=16412700; DOI=10.1016/j.modgep.2005.09.005;
RA Xiao L., Kim M., DeJong J.;
RT "Developmental and cell type-specific regulation of core promoter
RT transcription factors in germ cells of frogs and mice.";
RL Gene Expr. Patterns 6:409-419(2006).
CC -!- FUNCTION: The TFIID basal transcription factor complex plays a major
CC role in the initiation of RNA polymerase II (Pol II)-dependent
CC transcription. TFIID recognizes and binds promoters with or without a
CC TATA box via its subunit tbp, a TATA-box-binding protein, and promotes
CC assembly of the pre-initiation complex (PIC). The TFIID complex
CC consists of tbp and TBP-associated factors (TAFs).
CC {ECO:0000250|UniProtKB:P49848}.
CC -!- SUBUNIT: Component of the TFIID basal transcription factor complex,
CC composed of TATA-box-binding protein tbp, and a number of TBP-
CC associated factors (TAFs). Component of the TBP-free TAFII-histone
CC acetylase complex (TFTC-HAT). {ECO:0000250|UniProtKB:P49848}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in all tissues examined, including heart,
CC liver, lung, kidney, spleen, ovary and testis.
CC {ECO:0000269|PubMed:16412700}.
CC -!- SIMILARITY: Belongs to the TAF6 family. {ECO:0000305}.
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DR EMBL; D50054; BAA18922.1; -; mRNA.
DR EMBL; BC068776; AAH68776.1; -; mRNA.
DR PIR; JC4366; JC4366.
DR RefSeq; NP_001081232.1; NM_001087763.1.
DR AlphaFoldDB; Q91857; -.
DR SMR; Q91857; -.
DR BioGRID; 99064; 1.
DR IntAct; Q91857; 1.
DR DNASU; 397724; -.
DR GeneID; 397724; -.
DR KEGG; xla:397724; -.
DR CTD; 397724; -.
DR Xenbase; XB-GENE-5774722; taf6.L.
DR OrthoDB; 384329at2759; -.
DR Proteomes; UP000186698; Chromosome 3L.
DR Bgee; 397724; Expressed in oocyte and 19 other tissues.
DR GO; GO:0071339; C:MLL1 complex; ISS:UniProtKB.
DR GO; GO:0000124; C:SAGA complex; IEA:InterPro.
DR GO; GO:0046695; C:SLIK (SAGA-like) complex; IEA:InterPro.
DR GO; GO:0005669; C:transcription factor TFIID complex; IEA:InterPro.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IEA:InterPro.
DR CDD; cd08050; TAF6C; 1.
DR Gene3D; 1.10.20.10; -; 1.
DR Gene3D; 1.25.40.770; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR037796; TAF6.
DR InterPro; IPR011442; TAF6_C.
DR InterPro; IPR046344; TAF6_C_sf.
DR InterPro; IPR004823; TAF_TATA-bd_Histone-like_dom.
DR PANTHER; PTHR10221; PTHR10221; 1.
DR Pfam; PF02969; TAF; 1.
DR Pfam; PF07571; TAF6_C; 1.
DR SMART; SM00803; TAF; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..618
FT /note="Transcription initiation factor TFIID subunit 6"
FT /id="PRO_0000118876"
FT REGION 140..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 569..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..559
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 601..618
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 195
FT /note="E -> K (in Ref. 1; BAA18922)"
FT /evidence="ECO:0000305"
FT CONFLICT 378
FT /note="P -> A (in Ref. 1; BAA18922)"
FT /evidence="ECO:0000305"
FT CONFLICT 489
FT /note="P -> A (in Ref. 1; BAA18922)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 618 AA; 66858 MW; E42DD7601C816A22 CRC64;
MAEGKKIGNT LLPSESMKVI SESVGISQMS EETCQLLAQE VSFRIKEVTQ DALKFMHVGK
RQKLTPSDID AALKLKNVEP IYGFHPKEFL PFRYASGGGR ELHFYEEKET DLSDIISTPL
PRVPLDVSLK AHWLSIEGVQ PAIPENPPPV PKEQQKTEAT EPLKVAKPGQ EEGLPGKGQG
SGEGKGKEKK TAILEGAPLK LKPRSIHELS VEQQLYYKEI TEACVGSCEA KRAEALQSIA
TDPGLYQMLP RFSTFISEGV RVNVVQNNLA LLIYLMRMVK ALMDNPTLYL EKYLHELIPA
VMTCIVSRQL CLRPDVDNHW ALRDFAARLI AQICKNFSTT TNNIQSRITK TFTKTWVDDR
TPWTTRYGSI AGLAELGPDV VKTLIVPRLT VEGERLRSVL DGPVISNIDK IGADHVQSLL
LKHSAPVLVK LRSPPDSPDA YRADYGYLGP TLCTHVLKAR AQSALQGPQV NRTTLTVTQP
RPTLTLSQPS GSLTPSPRTP SIIKVPSSLT LPVQTLMSAR PATPTQPSPP PTKYIVVSSA
GSSGTQVLTT SSGPSPSTPG VQPIVKLVSG GQSSGVGGSM TGTGGGMQKY IVVSLPPAGE
SKTPQPSPPP PTTETSTL
