TAF73_SCHPO
ID TAF73_SCHPO Reviewed; 642 AA.
AC O74319;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Transcription initiation factor TFIID subunit taf73;
DE AltName: Full=Transcription initiation factor TFIID 73 kDa subunit;
DE Short=TAFII-73;
GN Name=taf73; ORFNames=SPBC15D4.14;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBUNIT.
RX PubMed=11279037; DOI=10.1074/jbc.m100248200;
RA Mitsuzawa H., Seino H., Yamao F., Ishihama A.;
RT "Two WD repeat-containing TATA-binding protein-associated factors in
RT fission yeast that suppress defects in the anaphase-promoting complex.";
RL J. Biol. Chem. 276:17117-17124(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: TAFs are components of the transcription factor IID (TFIID)
CC complex that are essential for mediating regulation of RNA polymerase
CC transcription. Regulates the genes involved in ubiquitin-dependent
CC proteolysis during the progression of M-phase of mitosis.
CC {ECO:0000269|PubMed:11279037}.
CC -!- SUBUNIT: TFIID is composed of TATA binding protein (TBP) and a number
CC of TBP-associated factors (TAFs) whose MWs range from 25-150 kDa.
CC {ECO:0000269|PubMed:11279037}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat TAF5 family. {ECO:0000305}.
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DR EMBL; CU329671; CAA20489.1; -; Genomic_DNA.
DR EMBL; AB039954; BAB12572.1; -; Genomic_DNA.
DR PIR; T39490; T39490.
DR RefSeq; NP_596254.1; NM_001022173.2.
DR AlphaFoldDB; O74319; -.
DR SMR; O74319; -.
DR BioGRID; 276428; 13.
DR IntAct; O74319; 4.
DR STRING; 4896.SPBC15D4.14.1; -.
DR iPTMnet; O74319; -.
DR MaxQB; O74319; -.
DR PaxDb; O74319; -.
DR PRIDE; O74319; -.
DR EnsemblFungi; SPBC15D4.14.1; SPBC15D4.14.1:pep; SPBC15D4.14.
DR GeneID; 2539882; -.
DR KEGG; spo:SPBC15D4.14; -.
DR PomBase; SPBC15D4.14; taf73.
DR VEuPathDB; FungiDB:SPBC15D4.14; -.
DR eggNOG; KOG0263; Eukaryota.
DR HOGENOM; CLU_005884_2_1_1; -.
DR InParanoid; O74319; -.
DR OMA; RPHQADV; -.
DR PhylomeDB; O74319; -.
DR Reactome; R-SPO-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-SPO-6807505; RNA polymerase II transcribes snRNA genes.
DR Reactome; R-SPO-73776; RNA Polymerase II Promoter Escape.
DR Reactome; R-SPO-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR Reactome; R-SPO-75953; RNA Polymerase II Transcription Initiation.
DR Reactome; R-SPO-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR PRO; PR:O74319; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005669; C:transcription factor TFIID complex; IDA:PomBase.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IC:PomBase.
DR GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IBA:GO_Central.
DR CDD; cd08044; TAF5_NTD2; 1.
DR Gene3D; 1.25.40.500; -; 1.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR006594; LisH.
DR InterPro; IPR037783; Taf5.
DR InterPro; IPR007582; TFIID_NTD2.
DR InterPro; IPR037264; TFIID_NTD2_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR19879; PTHR19879; 1.
DR Pfam; PF04494; TFIID_NTD2; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00667; LisH; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF160897; SSF160897; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50896; LISH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; WD repeat.
FT CHAIN 1..642
FT /note="Transcription initiation factor TFIID subunit taf73"
FT /id="PRO_0000234562"
FT DOMAIN 11..43
FT /note="LisH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00126"
FT REPEAT 347..386
FT /note="WD 1"
FT REPEAT 401..440
FT /note="WD 2"
FT REPEAT 443..482
FT /note="WD 3"
FT REPEAT 485..526
FT /note="WD 4"
FT REPEAT 528..566
FT /note="WD 5"
FT REPEAT 569..608
FT /note="WD 6"
SQ SEQUENCE 642 AA; 72251 MW; 6891234235FF6DBE CRC64;
MAQSSYSSGN STSDLNKIVL DYLFKKGYSR TEAMLRLEIS SVGAIPEEQQ DWHIGASETY
VQVYILLRDW IDGTLDLYKP KLQKVLYPIF VHSYLDLLQK NDPEMAIYFF ESFRIEHEVL
HGYDIRALAQ LKIASDVEEI EIAQLYRKNK YRINFTRSTF DLLVQFLFEN EVNGSGIIIR
LLNQYIDIKI TMPQVEGKED PNVQAVYEMD EAKNEQTIIS EQEGIPGHSE QLLDYNKQSI
QLGLRPLSEE VVTTLKNLLE VKDKDVEGRN EALNKILHPA KNLVELLTEK ENLINESTLE
SPSDPPLPPT KMKDIDYFVS LLESEQNSLI LGKNATDPSV FMYTMHNTLS AVNCAAFSDD
ASMFALGCAD SSIHLYSSTN NGPQPLVGSQ NEPLQKSSLI GHTRPVFGVS ISPQKEFILS
CSEDGFTRLW SKDTKSTIVK YAGHNAPIWD VQFSPFGYYF ATASHDQTAR LWDVEHAAPL
RVFVGHQNDV DCVSFHPNAA YLATGSSDHT TRMWDVRTGG TVRVFNAHHS PVSALCMSAD
GLSLASADES GIIKVWDLRS SNQHVSFVKH SSIVYSLSFS YDNKILVSGG ADTDVNFWDL
TYRNNLSDGE QSPLLFNFKT KNTIIQNLSF TRRNYCLALS SS