BPIB4_RAT
ID BPIB4_RAT Reviewed; 617 AA.
AC Q05704;
DT 29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=BPI fold-containing family B member 4;
DE AltName: Full=Ligand-binding protein RY2G5;
DE AltName: Full=Long palate, lung and nasal epithelium carcinoma-associated protein 4;
DE Flags: Precursor;
GN Name=Bpifb4; Synonyms=Lplunc4, Ry2g5;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 148-617.
RC STRAIN=Fischer; TISSUE=Olfactory epithelium;
RX PubMed=1915264; DOI=10.1002/j.1460-2075.1991.tb07830.x;
RA Dear T.N., Boehm T., Keverne E.B., Rabbitts T.H.;
RT "Novel genes for potential ligand-binding proteins in subregions of the
RT olfactory mucosa.";
RL EMBO J. 10:2813-2819(1991).
CC -!- FUNCTION: May have the capacity to recognize and bind specific classes
CC of odorants. May act as a carrier molecule, transporting odorants
CC across the mucus layer to access receptor sites. May serve as a primary
CC defense mechanism by recognizing and removing potentially harmful
CC odorants or pathogenic microorganisms from the mucosa or clearing
CC excess odorant from mucus to enable new odorant stimuli to be received
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Highly expressed in olfactory mucosa but
CC undetectable in thymus, kidney, lung, brain, spleen and liver.
CC -!- SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
CC {ECO:0000305}.
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DR EMBL; AABR03024115; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; X60660; CAA43067.1; -; mRNA.
DR RefSeq; NP_001102679.2; NM_001109209.2.
DR AlphaFoldDB; Q05704; -.
DR SMR; Q05704; -.
DR STRING; 10116.ENSRNOP00000047586; -.
DR GlyGen; Q05704; 1 site.
DR PaxDb; Q05704; -.
DR GeneID; 499925; -.
DR KEGG; rno:499925; -.
DR UCSC; RGD:1561174; rat.
DR CTD; 149954; -.
DR RGD; 1561174; Bpifb4.
DR VEuPathDB; HostDB:ENSRNOG00000034174; -.
DR eggNOG; KOG4160; Eukaryota.
DR HOGENOM; CLU_031635_0_0_1; -.
DR InParanoid; Q05704; -.
DR OMA; DLAFMPT; -.
DR OrthoDB; 1099604at2759; -.
DR PhylomeDB; Q05704; -.
DR TreeFam; TF315617; -.
DR Reactome; R-RNO-6803157; Antimicrobial peptides.
DR PRO; PR:Q05704; -.
DR Proteomes; UP000002494; Chromosome 3.
DR Bgee; ENSRNOG00000034174; Expressed in cerebellum and 2 other tissues.
DR Genevisible; Q05704; RN.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR InterPro; IPR001124; Lipid-bd_serum_glycop_C.
DR InterPro; IPR017942; Lipid-bd_serum_glycop_N.
DR Pfam; PF01273; LBP_BPI_CETP; 1.
DR Pfam; PF02886; LBP_BPI_CETP_C; 1.
DR SMART; SM00328; BPI1; 1.
DR SMART; SM00329; BPI2; 1.
DR SUPFAM; SSF55394; SSF55394; 2.
PE 2: Evidence at transcript level;
KW Cytoplasm; Disulfide bond; Glycoprotein; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..617
FT /note="BPI fold-containing family B member 4"
FT /id="PRO_0000089160"
FT REGION 124..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 275
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 297..334
FT /evidence="ECO:0000250"
SQ SEQUENCE 617 AA; 65580 MW; 7F70C7E8DCF73167 CRC64;
MWTAWCVAAL SVAAVCGIRQ DTTTVLRVTK DVLGDAISGT IQKSDAFRSA LREVPVGVGG
VPYNDFHVRE PPPKYTNGRQ LGGNYKYGHI EANDNTAQLG GKYRYGEILD SDGSLRDLRH
EDYRPSDSAY HRGPGRYRSA ADPSSAGRLH RRELRPGEIP AGVATGALGP GGLLGTGGIL
ANEGILAGQG GLLGGGGLLG DGGLLGGGGV LGVLGEGGIL STVQGITGLR IVELTLPRVS
VRLLPGVGVY LSLYTRVAIN GKSLIGFLDI AVEVNITAKV RLTMDRTGYP RLVIERCDTL
LGGIKVKLLR GLLPNLVDNL VNRVLANVLP DLLCPIVDVV LGLVNDQLGL VDSLVPLGIL
GSVQYTFSSL PLVTGEFLEL DLNTLVGEAG GDLIDYPLGR PAMLPRPQMP ELPPMGDNTN
SQLAISANFL SSVLTMLQKQ GALDIDITDG MFEDLPPLTT STLGALIPKV FQQYPESRPL
TIRIQVPNPP TVTLQKDKAL VKVFATSEVV VSQPNDVETT ICLIDVDTDL LASFSVEGDK
LMIDAKLDKT SLNLRTSNVG NFDVFILEML VEKIFDLAFM PAMNAILGSG VPLPKILNID
FSNADIDVLE DLLVLST
