TAF7_SCHPO
ID TAF7_SCHPO Reviewed; 393 AA.
AC O13701;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 130.
DE RecName: Full=Transcription initiation factor TFIID subunit 7;
DE AltName: Full=Transcription initiation factor TFIID 55 kDa subunit;
DE Short=TAFII-55;
GN Name=taf7; Synonyms=ptr6; ORFNames=SPAC13F5.02c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBCELLULAR LOCATION.
RC STRAIN=972 / ATCC 24843;
RX PubMed=10388808; DOI=10.1093/genetics/152.3.869;
RA Shibuya T., Tsuneyoshi S., Azad A.K., Urushiyama S., Ohshima Y., Tani T.;
RT "Characterization of the ptr6(+) gene in fission yeast: a possible
RT involvement of a transcriptional coactivator TAF in nucleocytoplasmic
RT transport of mRNA.";
RL Genetics 152:869-880(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-308 AND SER-310, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: TAFs are components of the transcription factor IID (TFIID)
CC complex that are essential for mediating regulation of RNA polymerase
CC transcription. Also involved in the transport of mRNA from the nucleus
CC to the cytoplasm. {ECO:0000269|PubMed:10388808}.
CC -!- SUBUNIT: TFIID is composed of TATA binding protein (TBP) and a number
CC of TBP-associated factors (TAFs).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10388808}.
CC -!- SIMILARITY: Belongs to the TAF7 family. {ECO:0000305}.
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DR EMBL; AB016928; BAA32487.1; -; Genomic_DNA.
DR EMBL; CU329670; CAB11765.1; -; Genomic_DNA.
DR PIR; T43401; T43401.
DR RefSeq; NP_593650.1; NM_001019082.2.
DR AlphaFoldDB; O13701; -.
DR SMR; O13701; -.
DR BioGRID; 279269; 9.
DR IntAct; O13701; 3.
DR STRING; 4896.SPAC13F5.02c.1; -.
DR iPTMnet; O13701; -.
DR SwissPalm; O13701; -.
DR MaxQB; O13701; -.
DR PaxDb; O13701; -.
DR PRIDE; O13701; -.
DR EnsemblFungi; SPAC13F5.02c.1; SPAC13F5.02c.1:pep; SPAC13F5.02c.
DR GeneID; 2542822; -.
DR KEGG; spo:SPAC13F5.02c; -.
DR PomBase; SPAC13F5.02c; taf7.
DR VEuPathDB; FungiDB:SPAC13F5.02c; -.
DR eggNOG; KOG4011; Eukaryota.
DR HOGENOM; CLU_016434_3_0_1; -.
DR InParanoid; O13701; -.
DR OMA; KTLQYPH; -.
DR PhylomeDB; O13701; -.
DR Reactome; R-SPO-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-SPO-73776; RNA Polymerase II Promoter Escape.
DR Reactome; R-SPO-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR Reactome; R-SPO-75953; RNA Polymerase II Transcription Initiation.
DR Reactome; R-SPO-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR PRO; PR:O13701; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; IDA:PomBase.
DR GO; GO:0005669; C:transcription factor TFIID complex; IDA:PomBase.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; ISO:PomBase.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0051123; P:RNA polymerase II preinitiation complex assembly; IBA:GO_Central.
DR CDD; cd08047; TAF7; 1.
DR InterPro; IPR037817; TAF7.
DR InterPro; IPR006751; TAFII55_prot_cons_reg.
DR PANTHER; PTHR12228; PTHR12228; 1.
DR Pfam; PF04658; TAFII55_N; 1.
DR SMART; SM01370; TAFII55_N; 1.
PE 1: Evidence at protein level;
KW mRNA transport; Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation; Transport.
FT CHAIN 1..393
FT /note="Transcription initiation factor TFIID subunit 7"
FT /id="PRO_0000118884"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 253..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..32
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..327
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 308
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 310
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 393 AA; 45000 MW; 58234FBA16998B5B CRC64;
MVKLKIRAVQ PPPNDSRSST PATGPPPPIP KIKIKTREPK GPRLTKIRLK RVREPGLGYD
SEASDREEDT YIEEQIILRL PPGEDCEYVR KAIENREVGR GADIWVKFKD QRRAVVHVNG
HLYAAKLVDL PCIIESNKSF DKKVIFKAAD ICQMLIATER IEHENSVLNT QLKQADYIYP
HGLTTPMHWV RQKRFRKRVS NRTIEAVENE VDRLLAMDER AESTSNELID QAQLARDSSI
ALSEDTSFDG MAGLRGTSID RDDQSVQTDM FDGMDEDDLA GQIEQGMLEL SQDTRESTAE
PRAAGEESAS EEEEEEEEEE EEENEADDET RENKRQNRLV REFISELESS IQKRRKDADE
ATNPILRNRF LADVNRMVTE LELKRTQLVD NPE
