ID   TAF8_CHICK              Reviewed;         244 AA.
AC   Q5ZMS1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Transcription initiation factor TFIID subunit 8;
DE   AltName: Full=TBP-associated factor 8;
GN   Name=TAF8; ORFNames=RCJMB04_1f12;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: The TFIID basal transcription factor complex plays a major
CC       role in the initiation of RNA polymerase II (Pol II)-dependent
CC       transcription. TFIID recognizes and binds promoters with or without a
CC       TATA box via its subunit TBP, a TATA-box-binding protein, and promotes
CC       assembly of the pre-initiation complex (PIC). The TFIID complex
CC       consists of TBP and TBP-associated factors (TAFs). Mediates both basal
CC       and activator-dependent transcription. {ECO:0000250|UniProtKB:Q7Z7C8}.
CC   -!- SUBUNIT: Component of the TFIID basal transcription factor complex,
CC       composed of TATA-box-binding protein TBP, and a number of TBP-
CC       associated factors (TAFs). {ECO:0000250|UniProtKB:Q7Z7C8}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TAF8 family. {ECO:0000305}.
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DR   EMBL; AJ719313; CAG30972.1; -; mRNA.
DR   RefSeq; NP_001026094.1; NM_001030923.1.
DR   AlphaFoldDB; Q5ZMS1; -.
DR   SMR; Q5ZMS1; -.
DR   STRING; 9031.ENSGALP00000042057; -.
DR   PaxDb; Q5ZMS1; -.
DR   Ensembl; ENSGALT00000005533; ENSGALP00000005523; ENSGALG00000003498.
DR   GeneID; 419929; -.
DR   KEGG; gga:419929; -.
DR   CTD; 129685; -.
DR   VEuPathDB; HostDB:geneid_419929; -.
DR   eggNOG; KOG4336; Eukaryota.
DR   GeneTree; ENSGT00390000017567; -.
DR   HOGENOM; CLU_070829_0_0_1; -.
DR   InParanoid; Q5ZMS1; -.
DR   PhylomeDB; Q5ZMS1; -.
DR   Reactome; R-GGA-6807505; RNA polymerase II transcribes snRNA genes.
DR   PRO; PR:Q5ZMS1; -.
DR   Proteomes; UP000000539; Chromosome 26.
DR   Bgee; ENSGALG00000003498; Expressed in spleen and 13 other tissues.
DR   ExpressionAtlas; Q5ZMS1; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005669; C:transcription factor TFIID complex; ISS:UniProtKB.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IBA:GO_Central.
DR   CDD; cd08049; TAF8; 1.
DR   Gene3D; 1.10.20.10; -; 1.
DR   InterPro; IPR006565; BTP.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR037818; TAF8.
DR   InterPro; IPR019473; TFIID_su8_C.
DR   PANTHER; PTHR46469; PTHR46469; 1.
DR   Pfam; PF07524; Bromo_TP; 1.
DR   Pfam; PF10406; TAF8_C; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Differentiation; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..244
FT                   /note="Transcription initiation factor TFIID subunit 8"
FT                   /id="PRO_0000315399"
FT   REGION          172..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           231..244
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        202..224
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   244 AA;  27511 MW;  C3C77D5643742033 CRC64;
     MLQSYISEIG RSAKSYCEHT ARTQPTLSDI VVTLVEMGFN VETLPAYAKR SQRMVITAPP
     VTNQPVTPKA LTAGQNKPHP SHIPGYFPEF PDPHTYIKTP TYREPVSDYQ VLREKAASQR
     RDVERALTRF MAKTGETQSL FKDDVSTFPL IAARPFTVPY LTALLPSELE MQQMEETDSS
     EQDDQTDTEN LPLHISTDDS GPEKENASVL QQNTSLSGSR NGEENMIDNP YLRPVKKPKI
     RRKK