TAF8_SCHPO
ID TAF8_SCHPO Reviewed; 222 AA.
AC O94706;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 120.
DE RecName: Full=Transcription initiation factor TFIID subunit 8;
DE AltName: Full=TBP-associated factor 8;
GN Name=taf8; ORFNames=SPCC1259.06;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Functions as a component of the DNA-binding general
CC transcription factor complex TFIID. Binding of TFIID to a promoter
CC (with or without TATA element) is the initial step in pre-initiation
CC complex (PIC) formation. TFIID plays a key role in the regulation of
CC gene expression by RNA polymerase II through different activities such
CC as transcription activator interaction, core promoter recognition and
CC selectivity, TFIIA and TFIIB interaction, chromatin modification,
CC facilitation of DNA opening and initiation of transcription (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: TFIID is composed of TATA binding protein (TBP) and a number
CC of TBP-associated factors (TAFs). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TAF8 family. {ECO:0000305}.
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DR EMBL; CU329672; CAA22544.1; -; Genomic_DNA.
DR PIR; T40895; T40895.
DR RefSeq; NP_588062.1; NM_001023054.2.
DR AlphaFoldDB; O94706; -.
DR SMR; O94706; -.
DR BioGRID; 275703; 1.
DR STRING; 4896.SPCC1259.06.1; -.
DR iPTMnet; O94706; -.
DR MaxQB; O94706; -.
DR PaxDb; O94706; -.
DR EnsemblFungi; SPCC1259.06.1; SPCC1259.06.1:pep; SPCC1259.06.
DR GeneID; 2539131; -.
DR KEGG; spo:SPCC1259.06; -.
DR PomBase; SPCC1259.06; taf8.
DR VEuPathDB; FungiDB:SPCC1259.06; -.
DR eggNOG; KOG4336; Eukaryota.
DR HOGENOM; CLU_1246004_0_0_1; -.
DR InParanoid; O94706; -.
DR OMA; NWESQKW; -.
DR PhylomeDB; O94706; -.
DR PRO; PR:O94706; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005669; C:transcription factor TFIID complex; ISO:PomBase.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; ISO:PomBase.
DR GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; ISO:PomBase.
DR CDD; cd08049; TAF8; 1.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR037818; TAF8.
DR InterPro; IPR019473; TFIID_su8_C.
DR PANTHER; PTHR46469; PTHR46469; 1.
DR Pfam; PF10406; TAF8_C; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..222
FT /note="Transcription initiation factor TFIID subunit 8"
FT /id="PRO_0000343160"
SQ SEQUENCE 222 AA; 25004 MW; A77F7594169200C3 CRC64;
MEAVIANILQ QLGFDSMTKA AEASFVEAVD KYLRNSFREL ALHTQLSKHT IPTTKDVALW
LNLLNIPMSS LQTELEKYLK PLPPAINDEL DRLANESQDI PSKFKSSLDS KMVSQLLGSL
AVSQNRPAYV VNHLPPFPAS HTYMATPVYP VRPTSPKQIR ELATQESRLA EHALRKILNV
NQPRSADSPR HASFEKACSE LNLDVSSFHL VNWESQKWSS QR