ID   TAF8_XENLA              Reviewed;         293 AA.
AC   Q7ZYA2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Transcription initiation factor TFIID subunit 8;
DE   AltName: Full=TBP-associated factor 8;
GN   Name=taf8;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The TFIID basal transcription factor complex plays a major
CC       role in the initiation of RNA polymerase II (Pol II)-dependent
CC       transcription. TFIID recognizes and binds promoters with or without a
CC       TATA box via its subunit tbp, a TATA-box-binding protein, and promotes
CC       assembly of the pre-initiation complex (PIC). The TFIID complex
CC       consists of tbp and TBP-associated factors (TAFs). Mediates both basal
CC       and activator-dependent transcription. {ECO:0000250|UniProtKB:Q7Z7C8}.
CC   -!- SUBUNIT: Component of the TFIID basal transcription factor complex,
CC       composed of TATA-box-binding protein tbp, and a number of TBP-
CC       associated factors (TAFs). {ECO:0000250|UniProtKB:Q7Z7C8}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TAF8 family. {ECO:0000305}.
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DR   EMBL; BC043877; AAH43877.1; -; mRNA.
DR   RefSeq; NP_001080509.1; NM_001087040.1.
DR   AlphaFoldDB; Q7ZYA2; -.
DR   SMR; Q7ZYA2; -.
DR   MaxQB; Q7ZYA2; -.
DR   DNASU; 380201; -.
DR   GeneID; 380201; -.
DR   KEGG; xla:380201; -.
DR   CTD; 380201; -.
DR   Xenbase; XB-GENE-6253923; taf8.S.
DR   OrthoDB; 1290064at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 380201; Expressed in blastula and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005669; C:transcription factor TFIID complex; ISS:UniProtKB.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   CDD; cd08049; TAF8; 1.
DR   Gene3D; 1.10.20.10; -; 1.
DR   InterPro; IPR006565; BTP.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR037818; TAF8.
DR   InterPro; IPR019473; TFIID_su8_C.
DR   PANTHER; PTHR46469; PTHR46469; 1.
DR   Pfam; PF07524; Bromo_TP; 1.
DR   Pfam; PF10406; TAF8_C; 1.
DR   SMART; SM00576; BTP; 1.
DR   SUPFAM; SSF47113; SSF47113; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Differentiation; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..293
FT                   /note="Transcription initiation factor TFIID subunit 8"
FT                   /id="PRO_0000315401"
FT   DOMAIN          25..92
FT                   /note="Histone-fold"
FT   REGION          247..293
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           280..293
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   293 AA;  32733 MW;  7B92AE558809BF0E CRC64;
     MFPTIRSCAR GTSTPADNYM LARRRTLQVV VSSLLTEAGF DSAEKAAVES LTEMLQSYLS
     EIGRSAKSYC EHTARTQPTL PDIVVTLIEM GFNVDSLPAY AKRSQRMVIT APPVTNNPVV
     PKALSAGDNK PHPAHIPSHF PEFPDPHTYI KTPTYREPVC DYQVLREKAA SQRRDVERAL
     TRFMAKTGET QSLFKDDTST FPLIAARPLS IPYLNALLPS ELELQQVDET DSSEQDDQTD
     TENLSLHLQG DEVGMEKENA SVLQQNSMKG GEETLIDNPY LRPVKKPKLR RKK