ID   TAF8_XENTR              Reviewed;         293 AA.
AC   Q28J24; A4II75;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Transcription initiation factor TFIID subunit 8;
DE   AltName: Full=TBP-associated factor 8;
GN   Name=taf8; ORFNames=TNeu125i04.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The TFIID basal transcription factor complex plays a major
CC       role in the initiation of RNA polymerase II (Pol II)-dependent
CC       transcription. TFIID recognizes and binds promoters with or without a
CC       TATA box via its subunit tbp, a TATA-box-binding protein, and promotes
CC       assembly of the pre-initiation complex (PIC). The TFIID complex
CC       consists of tbp and TBP-associated factors (TAFs). Mediates both basal
CC       and activator-dependent transcription. {ECO:0000250|UniProtKB:Q7Z7C8}.
CC   -!- SUBUNIT: Component of the TFIID basal transcription factor complex,
CC       composed of TATA-box-binding protein tbp, and a number of TBP-
CC       associated factors (TAFs). {ECO:0000250|UniProtKB:Q7Z7C8}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TAF8 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI35895.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CR760093; CAJ82344.1; -; mRNA.
DR   EMBL; BC135894; AAI35895.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001016717.1; NM_001016717.2.
DR   RefSeq; XP_012818203.1; XM_012962749.1.
DR   AlphaFoldDB; Q28J24; -.
DR   SMR; Q28J24; -.
DR   STRING; 8364.ENSXETP00000025890; -.
DR   PaxDb; Q28J24; -.
DR   PRIDE; Q28J24; -.
DR   Ensembl; ENSXETT00000025890; ENSXETP00000025890; ENSXETG00000011845.
DR   GeneID; 549471; -.
DR   KEGG; xtr:549471; -.
DR   CTD; 129685; -.
DR   Xenbase; XB-GENE-491356; taf8.
DR   eggNOG; KOG4336; Eukaryota.
DR   HOGENOM; CLU_070829_0_0_1; -.
DR   InParanoid; Q28J24; -.
DR   OrthoDB; 1290064at2759; -.
DR   PhylomeDB; Q28J24; -.
DR   Reactome; R-XTR-6807505; RNA polymerase II transcribes snRNA genes.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000011845; Expressed in testis and 12 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005669; C:transcription factor TFIID complex; ISS:UniProtKB.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IBA:GO_Central.
DR   CDD; cd08049; TAF8; 1.
DR   Gene3D; 1.10.20.10; -; 1.
DR   InterPro; IPR006565; BTP.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR037818; TAF8.
DR   InterPro; IPR019473; TFIID_su8_C.
DR   PANTHER; PTHR46469; PTHR46469; 1.
DR   Pfam; PF07524; Bromo_TP; 1.
DR   Pfam; PF10406; TAF8_C; 1.
DR   SMART; SM00576; BTP; 1.
DR   SUPFAM; SSF47113; SSF47113; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Differentiation; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..293
FT                   /note="Transcription initiation factor TFIID subunit 8"
FT                   /id="PRO_0000315402"
FT   DOMAIN          25..92
FT                   /note="Histone-fold"
FT   REGION          226..293
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           280..293
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        258..272
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   293 AA;  32823 MW;  A7DA6B1A984EF797 CRC64;
     MFPTIRSCAR GTSTPADNYM LARRRTLQVV VSSLLTEAGF ESAEKAAVES LTEMLQSYLS
     EIGRSAKSYC EHTARTQPTL PDIVVTLIEM GFNVESLPAY AKRSQRMVIT APPVTNNPVV
     PKALSAGQNK QHPAHIPSHF PEFPDPHTYI KTPTYREPVC DYQVLREKAA SQRRDVERAL
     TRFMAKTGET QSLFKDDTST FPLIAARPLS IPYLNALLPS ELELQQVEET DSSEQDDQTD
     AENLSMHLQG DEVGMEKENS SVLQQNSMKG GEETLIDNPY LRPVKKPKLR RKK