TAF9B_MOUSE
ID TAF9B_MOUSE Reviewed; 249 AA.
AC Q6NZA9; A2AP80; Q3UXZ3; Q3V2M4; Q80WW6;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Transcription initiation factor TFIID subunit 9B;
DE AltName: Full=Transcription initiation factor TFIID subunit 9-like;
DE AltName: Full=Transcription-associated factor TAFII31L;
GN Name=Taf9b; Synonyms=Taf9l;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:BAE22420.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAE22420.1};
RC TISSUE=Olfactory bulb {ECO:0000312|EMBL:BAE22420.1}, and
RC Testis {ECO:0000312|EMBL:BAE20773.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000312|EMBL:AAH66223.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAH51635.1, ECO:0000312|EMBL:AAH66223.1};
RC TISSUE=Embryo {ECO:0000312|EMBL:AAH51635.1}, and
RC Kidney {ECO:0000312|EMBL:AAH66223.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Essential for cell viability. TAF9 and TAF9B are involved in
CC transcriptional activation as well as repression of distinct but
CC overlapping sets of genes. May have a role in gene regulation
CC associated with apoptosis. TAFs are components of the transcription
CC factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF
CC histone acetylase complex and the STAGA transcription coactivator-HAT
CC complex. TFIID or TFTC are essential for the regulation of RNA
CC polymerase II-mediated transcription (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Binds TAF5 and TAF6. Component of TFIID and the TATA-binding
CC protein-free TAF complex (TFTC). TFIID is composed of TATA binding
CC protein (TBP) and a number of TBP-associated factors (TAFs). Binds N-
CC terminal domain of p53/TP53 which is essential for transcription (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TAF9 family. {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH51635.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAE20773.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK131710; BAE20773.1; ALT_INIT; mRNA.
DR EMBL; AK135097; BAE22420.1; -; mRNA.
DR EMBL; AL833778; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC051635; AAH51635.1; ALT_INIT; mRNA.
DR EMBL; BC066223; AAH66223.1; -; mRNA.
DR CCDS; CCDS30340.1; -.
DR RefSeq; NP_001001176.2; NM_001001176.2.
DR RefSeq; NP_001161460.1; NM_001167988.1.
DR AlphaFoldDB; Q6NZA9; -.
DR SMR; Q6NZA9; -.
DR STRING; 10090.ENSMUSP00000109123; -.
DR iPTMnet; Q6NZA9; -.
DR PhosphoSitePlus; Q6NZA9; -.
DR jPOST; Q6NZA9; -.
DR MaxQB; Q6NZA9; -.
DR PaxDb; Q6NZA9; -.
DR PRIDE; Q6NZA9; -.
DR ProteomicsDB; 263249; -.
DR Antibodypedia; 28250; 135 antibodies from 23 providers.
DR DNASU; 407786; -.
DR Ensembl; ENSMUST00000055497; ENSMUSP00000059751; ENSMUSG00000047242.
DR GeneID; 407786; -.
DR KEGG; mmu:407786; -.
DR UCSC; uc009ubq.2; mouse.
DR CTD; 51616; -.
DR MGI; MGI:3039562; Taf9b.
DR VEuPathDB; HostDB:ENSMUSG00000047242; -.
DR eggNOG; KOG3334; Eukaryota.
DR GeneTree; ENSGT00940000161697; -.
DR HOGENOM; CLU_068315_2_0_1; -.
DR InParanoid; Q6NZA9; -.
DR OMA; PNYRLKP; -.
DR OrthoDB; 1429345at2759; -.
DR PhylomeDB; Q6NZA9; -.
DR Reactome; R-MMU-5689880; Ub-specific processing proteases.
DR Reactome; R-MMU-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-MMU-6804756; Regulation of TP53 Activity through Phosphorylation.
DR Reactome; R-MMU-73776; RNA Polymerase II Promoter Escape.
DR Reactome; R-MMU-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR Reactome; R-MMU-75953; RNA Polymerase II Transcription Initiation.
DR Reactome; R-MMU-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR BioGRID-ORCS; 407786; 4 hits in 70 CRISPR screens.
DR PRO; PR:Q6NZA9; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q6NZA9; protein.
DR Bgee; ENSMUSG00000047242; Expressed in animal zygote and 213 other tissues.
DR ExpressionAtlas; Q6NZA9; baseline and differential.
DR Genevisible; Q6NZA9; MM.
DR GO; GO:0005669; C:transcription factor TFIID complex; ISO:MGI.
DR GO; GO:0033276; C:transcription factor TFTC complex; ISO:MGI.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISO:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0030307; P:positive regulation of cell growth; ISO:MGI.
DR GO; GO:0050821; P:protein stabilization; ISO:MGI.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:GOC.
DR CDD; cd07979; TAF9; 1.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR003162; TFIID-31.
DR Pfam; PF02291; TFIID-31kDa; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
PE 1: Evidence at protein level;
KW Acetylation; Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..249
FT /note="Transcription initiation factor TFIID subunit 9B"
FT /id="PRO_0000118892"
FT REGION 148..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 224..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..249
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9HBM6"
FT MOD_RES 147
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9HBM6"
FT MOD_RES 172
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9HBM6"
FT MOD_RES 175
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9HBM6"
FT CONFLICT 28
FT /note="I -> T (in Ref. 3; AAH66223)"
FT /evidence="ECO:0000305"
FT CONFLICT 193
FT /note="A -> T (in Ref. 1; BAE22420)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 249 AA; 27172 MW; 5615C356885322FD CRC64;
MEPAKMAPIK NAPRDALVMA QILKDMGITE YEPRVINQML EFAFRYVTTI LDDAKIYSSH
AKKPTVDADD VRLAIQCRAD QSFTSPPPRD FLLDIARQKN QTPLPLIKPY AGPRLPPDRY
CLTAPNYRLK SLVKKGPNQG RLVPRLSAVS SRPTTPPVAP PQAVSGPNKA ATPVSVTSQR
FAVQIPPSQS TPAKPAPAAT AVQNVLINPS MIGPKNILIT TSMVSSQNTA TDSNPLKRKH
DDDDDNDTM
