BPIB6_MOUSE
ID BPIB6_MOUSE Reviewed; 449 AA.
AC Q8BU51; A2APD0; Q80ZU8;
DT 29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=BPI fold-containing family B member 6;
DE AltName: Full=Bactericidal/permeability-increasing protein-like 3;
DE Flags: Precursor;
GN Name=Bpifb6; Synonyms=Bpil3, Gm119;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 335-449.
RC STRAIN=C57BL/6J; TISSUE=Ovary;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC39978.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL833803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC048083; AAH48083.1; -; mRNA.
DR EMBL; AK087711; BAC39978.1; ALT_INIT; mRNA.
DR CCDS; CCDS16920.1; -.
DR RefSeq; NP_955007.2; NM_199303.2.
DR RefSeq; XP_017173296.1; XM_017317807.1.
DR AlphaFoldDB; Q8BU51; -.
DR SMR; Q8BU51; -.
DR STRING; 10090.ENSMUSP00000086347; -.
DR GlyGen; Q8BU51; 1 site.
DR iPTMnet; Q8BU51; -.
DR PhosphoSitePlus; Q8BU51; -.
DR PaxDb; Q8BU51; -.
DR PRIDE; Q8BU51; -.
DR ProteomicsDB; 265456; -.
DR Antibodypedia; 25493; 66 antibodies from 14 providers.
DR DNASU; 228796; -.
DR Ensembl; ENSMUST00000088955; ENSMUSP00000086347; ENSMUSG00000068009.
DR GeneID; 228796; -.
DR KEGG; mmu:228796; -.
DR UCSC; uc008nio.2; mouse.
DR CTD; 128859; -.
DR MGI; MGI:2684965; Bpifb6.
DR VEuPathDB; HostDB:ENSMUSG00000068009; -.
DR eggNOG; KOG4160; Eukaryota.
DR GeneTree; ENSGT01020000230460; -.
DR HOGENOM; CLU_031635_1_0_1; -.
DR InParanoid; Q8BU51; -.
DR OMA; FMGGNME; -.
DR OrthoDB; 1099604at2759; -.
DR PhylomeDB; Q8BU51; -.
DR TreeFam; TF315617; -.
DR Reactome; R-MMU-6803157; Antimicrobial peptides.
DR BioGRID-ORCS; 228796; 1 hit in 73 CRISPR screens.
DR PRO; PR:Q8BU51; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8BU51; protein.
DR Bgee; ENSMUSG00000068009; Expressed in ovary and 6 other tissues.
DR ExpressionAtlas; Q8BU51; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR InterPro; IPR032948; BPIFB6.
DR InterPro; IPR001124; Lipid-bd_serum_glycop_C.
DR InterPro; IPR017942; Lipid-bd_serum_glycop_N.
DR PANTHER; PTHR46019:SF2; PTHR46019:SF2; 1.
DR Pfam; PF01273; LBP_BPI_CETP; 1.
DR Pfam; PF02886; LBP_BPI_CETP_C; 1.
DR SMART; SM00329; BPI2; 1.
DR SUPFAM; SSF55394; SSF55394; 2.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..449
FT /note="BPI fold-containing family B member 6"
FT /id="PRO_0000017169"
FT CARBOHYD 115
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 138..172
FT /evidence="ECO:0000250"
FT CONFLICT 385..386
FT /note="SS -> FF (in Ref. 2; AAH48083)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 449 AA; 48781 MW; EF5EFCB3D4401DC3 CRC64;
MLCSLSLVLC GLLAGTRADP GGLLRLGMDI MNHEVQSAME ESHILEKMAA EASNPQPGGK
AIKGLSNMKV KDVLEPVITL NFVPGVGISQ CVSTGMTITG KSFTGGNMEI NVVLNITATD
RLLQDEEAGT PVFRSEGCEV ILVSVKTNLP NNKAINKFVD STLRKVLPGL MCPAIDAVLE
YVNKKWAKLT DPMPVDKMGT VKYALTSPPA TTASHIQVDF SPVVQLQEGQ LIQLATDGSL
PEFPEGSAKD SQLLLSATFL TAELALLQKS LEVKLKDKRV GKLPQNTRTL AGFIPQVAKT
YHKPKPLLIK VKINKPPKVT MKAGKSLMHL HGSLEMFAAR RHGKHPKSLF RLETHIGLEI
HYSVQDNRLQ MVTSMDSLLS LARESSSVGD FHEAELTGFI TDYLQKAYIP VVNDVLHVGL
PLPDLLAINY NLAELDIVED ALVLGLKTE
