TAF9B_RAT
ID TAF9B_RAT Reviewed; 258 AA.
AC Q62880; Q5EAN8;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Transcription initiation factor TFIID subunit 9B;
DE AltName: Full=Neuronal cell death-related gene in neuron 7;
DE Short=DN-7;
DE AltName: Full=Transcription initiation factor TFIID subunit 9-like;
DE AltName: Full=Transcription-associated factor TAFII31L;
GN Name=Taf9b; Synonyms=Dn7, Taf9l;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Brown Norway; TISSUE=Heart;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 5-258, AND INDUCTION.
RX PubMed=9168994; DOI=10.1006/bbrc.1997.6610;
RA Aoki T., Koike T., Nakano T., Shibahara K., Nishimura H., Kikuchi H.,
RA Honjo T.;
RT "Rat TAFII31 gene is induced upon programmed cell death in differentiated
RT PC12 cells deprived of NGF.";
RL Biochem. Biophys. Res. Commun. 234:230-234(1997).
CC -!- FUNCTION: Essential for cell viability. TAF9 and TAF9L are involved in
CC transcriptional activation as well as repression of distinct but
CC overlapping sets of genes. May have a role in gene regulation
CC associated with apoptosis. TAFs are components of the transcription
CC factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF
CC histone acetylase complex and the STAGA transcription coactivator-HAT
CC complex. TFIID or TFTC are essential for the regulation of RNA
CC polymerase II-mediated transcription (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Binds TAF5 and TAF6. Component of TFIID and the TATA-binding
CC protein-free TAF complex (TFTC). TFIID is composed of TATA binding
CC protein (TBP) and a number of TBP-associated factors (TAFs). Binds N-
CC terminal domain of p53/TP53 which is essential for transcription (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- INDUCTION: By apoptotic signals in PC12 cells.
CC {ECO:0000269|PubMed:9168994}.
CC -!- SIMILARITY: Belongs to the TAF9 family. {ECO:0000305}.
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DR EMBL; U40188; AAC53201.1; -; mRNA.
DR EMBL; BC090332; AAH90332.1; -; mRNA.
DR PIR; JC5511; JC5511.
DR RefSeq; NP_598299.1; NM_133615.1.
DR RefSeq; XP_006257056.1; XM_006256994.3.
DR AlphaFoldDB; Q62880; -.
DR SMR; Q62880; -.
DR STRING; 10116.ENSRNOP00000068201; -.
DR iPTMnet; Q62880; -.
DR PhosphoSitePlus; Q62880; -.
DR PaxDb; Q62880; -.
DR GeneID; 171152; -.
DR KEGG; rno:171152; -.
DR UCSC; RGD:621116; rat.
DR CTD; 51616; -.
DR RGD; 621116; Taf9b.
DR VEuPathDB; HostDB:ENSRNOG00000061102; -.
DR eggNOG; KOG3334; Eukaryota.
DR InParanoid; Q62880; -.
DR OrthoDB; 1429345at2759; -.
DR PhylomeDB; Q62880; -.
DR TreeFam; TF351417; -.
DR Reactome; R-RNO-5689880; Ub-specific processing proteases.
DR Reactome; R-RNO-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-RNO-6804756; Regulation of TP53 Activity through Phosphorylation.
DR Reactome; R-RNO-73776; RNA Polymerase II Promoter Escape.
DR Reactome; R-RNO-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR Reactome; R-RNO-75953; RNA Polymerase II Transcription Initiation.
DR Reactome; R-RNO-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR PRO; PR:Q62880; -.
DR Proteomes; UP000002494; Chromosome X.
DR Bgee; ENSRNOG00000061102; Expressed in cerebellum and 20 other tissues.
DR ExpressionAtlas; Q62880; baseline and differential.
DR Genevisible; Q62880; RN.
DR GO; GO:0005669; C:transcription factor TFIID complex; ISO:RGD.
DR GO; GO:0033276; C:transcription factor TFTC complex; ISO:RGD.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISO:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0030307; P:positive regulation of cell growth; ISO:RGD.
DR GO; GO:0012501; P:programmed cell death; IEP:RGD.
DR GO; GO:0050821; P:protein stabilization; ISO:RGD.
DR GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:GOC.
DR CDD; cd07979; TAF9; 1.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR003162; TFIID-31.
DR Pfam; PF02291; TFIID-31kDa; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..258
FT /note="Transcription initiation factor TFIID subunit 9B"
FT /id="PRO_0000118893"
FT REGION 227..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9HBM6"
FT MOD_RES 147
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9HBM6"
FT MOD_RES 159
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9HBM6"
FT MOD_RES 174
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9HBM6"
FT MOD_RES 177
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9HBM6"
FT CONFLICT 217
FT /note="K -> T (in Ref. 2; AAC53201)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 258 AA; 28220 MW; 42244D3E14F238B2 CRC64;
MEPSKMAPLK NAPRDALVMA QILKDMGITD YEPRVINQML EFAFRYVTTI LDDAKIYSSH
AKKPTVDADD VRLAIQCRAD QSFTSPPPRD FLLDIARQKN QTPLPLIKPY AGPRLPPDRY
CLTAPNYRLK SLVKKGPNQG RLVPRLSVGA VSSRPTTPTV APPQAVSVPN KVATPVSVTS
QRFAVQIPTS QSTPAKPAPA ATSVQNVLIN PSMIGSKNIL ITTNMVSSQS TATDSNPLKR
KHDDDDDDDD DDDDNDTM
