TAF9_CAEEL
ID TAF9_CAEEL Reviewed; 183 AA.
AC O45784;
DT 25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Transcription initiation factor TFIID subunit 9 {ECO:0000305};
DE AltName: Full=TBP-associated transcription factor family member taf-9 {ECO:0000312|WormBase:T12D8.7};
GN Name=taf-9 {ECO:0000312|WormBase:T12D8.7};
GN Synonyms=taf-10 {ECO:0000303|PubMed:11566890};
GN ORFNames=T12D8.7 {ECO:0000312|WormBase:T12D8.7};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=11566890; DOI=10.1093/emboj/20.18.5269;
RA Walker A.K., Rothman J.H., Shi Y., Blackwell T.K.;
RT "Distinct requirements for C.elegans TAF(II)s in early embryonic
RT transcription.";
RL EMBO J. 20:5269-5279(2001).
RN [3] {ECO:0000305}
RP NOMENCLATURE.
RX PubMed=11963920; DOI=10.1101/gad.976402;
RA Tora L.;
RT "A unified nomenclature for TATA box binding protein (TBP)-associated
RT factors (TAFs) involved in RNA polymerase II transcription.";
RL Genes Dev. 16:673-675(2002).
CC -!- FUNCTION: The TFIID basal transcription factor complex plays a major
CC role in the initiation of RNA polymerase II (Pol II)-dependent
CC transcription (By similarity). TFIID recognizes and binds promoters via
CC its subunit tbp-1, a TATA-box-binding protein, and promotes assembly of
CC the pre-initiation complex (PIC) (By similarity). The TFIID complex
CC consists of tbp-1 and TBP-associated factors (TAFs), including taf-9
CC (By similarity). Essential for early embryonic development, but not
CC required for transcription of some genes; probably acts via activating
CC transcription initiation by RNA Pol II, as part of the TFIID complex
CC (PubMed:11566890). {ECO:0000250|UniProtKB:Q16594,
CC ECO:0000269|PubMed:11566890}.
CC -!- SUBUNIT: Component of the TFIID basal transcription factor complex,
CC composed of TATA-box-binding protein tbp-1, and a number of TBP-
CC associated factors (TAFs). {ECO:0000250|UniProtKB:Q16594}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11566890}.
CC -!- DEVELOPMENTAL STAGE: Expressed from the 4-cell stage through late
CC gastrulation (at protein level) (PubMed:11566890). May be maternally
CC expressed (PubMed:11566890). {ECO:0000269|PubMed:11566890,
CC ECO:0000303|PubMed:11566890}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown causes arrested
CC development at 90-100 cells and inhibits differentiation
CC (PubMed:11566890). The two E cell daughters (E2 cells), which form the
CC endoderm, divide abnormally early, immediately after the MS2 cells
CC (PubMed:11566890). Phosphorylation of the RNA Pol II large subunit C-
CC terminal domain (CTD) is reduced slightly in embryos (PubMed:11566890).
CC Abolishes expression of taf-10, perhaps as a result of altered protein
CC stability (PubMed:11566890). Reduces expression of a range of genes,
CC including let-858, rps-5, hsp16.2, and pes-10, but has little or no
CC effect on expression of cki-2 and sur-5 (PubMed:11566890).
CC {ECO:0000269|PubMed:11566890}.
CC -!- SIMILARITY: Belongs to the TAF9 family. {ECO:0000305}.
CC -!- CAUTION: Throughout PMID:11566890, the gene name taf-10 is used instead
CC of taf-9, based on an earlier nomenclature; readers should be aware to
CC avoid confusion. {ECO:0000303|PubMed:11963920,
CC ECO:0000305|PubMed:11566890}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX284603; CAB03347.1; -; Genomic_DNA.
DR PIR; T24863; T24863.
DR RefSeq; NP_499814.1; NM_067413.4.
DR AlphaFoldDB; O45784; -.
DR SMR; O45784; -.
DR DIP; DIP-27361N; -.
DR IntAct; O45784; 18.
DR STRING; 6239.T12D8.7; -.
DR EPD; O45784; -.
DR PaxDb; O45784; -.
DR PeptideAtlas; O45784; -.
DR EnsemblMetazoa; T12D8.7.1; T12D8.7.1; WBGene00006391.
DR GeneID; 176798; -.
DR KEGG; cel:CELE_T12D8.7; -.
DR UCSC; T12D8.7; c. elegans.
DR CTD; 176798; -.
DR WormBase; T12D8.7; CE16404; WBGene00006391; taf-9.
DR eggNOG; KOG3334; Eukaryota.
DR GeneTree; ENSGT00940000169542; -.
DR HOGENOM; CLU_068315_6_1_1; -.
DR InParanoid; O45784; -.
DR OMA; PHDAQVM; -.
DR OrthoDB; 1429345at2759; -.
DR PhylomeDB; O45784; -.
DR Reactome; R-CEL-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-CEL-6807505; RNA polymerase II transcribes snRNA genes.
DR Reactome; R-CEL-73776; RNA Polymerase II Promoter Escape.
DR Reactome; R-CEL-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR Reactome; R-CEL-75953; RNA Polymerase II Transcription Initiation.
DR Reactome; R-CEL-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR PRO; PR:O45784; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00006391; Expressed in embryo and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0000124; C:SAGA complex; IBA:GO_Central.
DR GO; GO:0005669; C:transcription factor TFIID complex; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
DR GO; GO:0043966; P:histone H3 acetylation; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:WormBase.
DR GO; GO:0009794; P:regulation of mitotic cell cycle, embryonic; IMP:WormBase.
DR GO; GO:0051123; P:RNA polymerase II preinitiation complex assembly; IBA:GO_Central.
DR CDD; cd07979; TAF9; 1.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR003162; TFIID-31.
DR Pfam; PF02291; TFIID-31kDa; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..183
FT /note="Transcription initiation factor TFIID subunit 9"
FT /id="PRO_0000455415"
SQ SEQUENCE 183 AA; 20644 MW; 341FC3973CC98520 CRC64;
MADTGEKDTE TTASGTDGHS KEALAVISML HECGIQEFDP RVVSMLMDVQ YAVTSKILQM
SSGLSRHAEK AQIEAEDVQT AADMLGVLTT NAPDREKILQ LANDKNQQPL PQIRHNYGLK
LPNDRFCQLQ QNFVYKADDS YQPMEMQQVT HQPHIIEPPT QVLRPEHVQN MLKRRAPDDD
FDS
