ID   ABTB2_MOUSE             Reviewed;        1024 AA.
AC   Q7TQI7;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Ankyrin repeat and BTB/POZ domain-containing protein 2;
GN   Name=Abtb2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Heart, Liver, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: May be involved in the initiation of hepatocyte growth.
CC       {ECO:0000250}.
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DR   EMBL; BC054399; AAH54399.1; -; mRNA.
DR   CCDS; CCDS16479.1; -.
DR   RefSeq; NP_849221.2; NM_178890.3.
DR   AlphaFoldDB; Q7TQI7; -.
DR   SMR; Q7TQI7; -.
DR   BioGRID; 221238; 2.
DR   STRING; 10090.ENSMUSP00000075566; -.
DR   iPTMnet; Q7TQI7; -.
DR   PhosphoSitePlus; Q7TQI7; -.
DR   EPD; Q7TQI7; -.
DR   MaxQB; Q7TQI7; -.
DR   PaxDb; Q7TQI7; -.
DR   PRIDE; Q7TQI7; -.
DR   ProteomicsDB; 285969; -.
DR   Antibodypedia; 12992; 68 antibodies from 17 providers.
DR   Ensembl; ENSMUST00000076212; ENSMUSP00000075566; ENSMUSG00000032724.
DR   GeneID; 99382; -.
DR   KEGG; mmu:99382; -.
DR   UCSC; uc008lix.1; mouse.
DR   CTD; 25841; -.
DR   MGI; MGI:2139365; Abtb2.
DR   VEuPathDB; HostDB:ENSMUSG00000032724; -.
DR   eggNOG; ENOG502QSQY; Eukaryota.
DR   GeneTree; ENSGT00940000157661; -.
DR   HOGENOM; CLU_001918_0_0_1; -.
DR   InParanoid; Q7TQI7; -.
DR   OMA; LQCNGST; -.
DR   OrthoDB; 416322at2759; -.
DR   PhylomeDB; Q7TQI7; -.
DR   TreeFam; TF106437; -.
DR   BioGRID-ORCS; 99382; 1 hit in 73 CRISPR screens.
DR   ChiTaRS; Abtb2; mouse.
DR   PRO; PR:Q7TQI7; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; Q7TQI7; protein.
DR   Bgee; ENSMUSG00000032724; Expressed in stria vascularis of cochlear duct and 257 other tissues.
DR   ExpressionAtlas; Q7TQI7; baseline and differential.
DR   Genevisible; Q7TQI7; MM.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0097237; P:cellular response to toxic substance; IMP:MGI.
DR   Gene3D; 1.10.20.10; -; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   Pfam; PF00023; Ank; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00651; BTB; 1.
DR   SMART; SM00248; ANK; 5.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF47113; SSF47113; 2.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 3.
DR   PROSITE; PS50097; BTB; 1.
PE   1: Evidence at protein level;
KW   ANK repeat; Reference proteome; Repeat.
FT   CHAIN           1..1024
FT                   /note="Ankyrin repeat and BTB/POZ domain-containing protein
FT                   2"
FT                   /id="PRO_0000066888"
FT   REPEAT          521..550
FT                   /note="ANK 1"
FT   REPEAT          567..596
FT                   /note="ANK 2"
FT   REPEAT          606..635
FT                   /note="ANK 3"
FT   REPEAT          649..678
FT                   /note="ANK 4"
FT   DOMAIN          844..913
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
SQ   SEQUENCE   1024 AA;  113503 MW;  39509A02F0DE093A CRC64;
     MAGTYSSTLK TLEDLTLDSG YGAGDSCRSL SLSSSKSNSQ ALNSSAQQHR GAAWWCYSGS
     MNSRHNSWDT VNTVLPEDPE VADLFSRCPR LPELEEFPWT EGDVARVLRK SVGGRRLPSF
     SAEAVRRLAG LLRRALIRVA REAQRLSVLH AKCTRFEVQS AVRLVHSWAL AESCALAAVK
     ALSLYSMSAG DGLRRGKSAR CGLTFSVGRF FRWMVDTRIS VRIHEYAAIS LTACMENLVE
     EIRARVLASQ SPDGGGAGGG EVSAEALEMV INNDAELWGV LQPYEHLICG KNANGVLSLP
     AYFSPYNGGS LGHDERADAY AQLELRTLEQ SLLATCVGSI SELSDLVSRA MHHMQGRHPL
     CPGTSPARQA RQPPQPITWS PDALHTLYYF LRCPQMESME NPNLDPPRMT LNNERPFMLL
     PPLMEWMRVA ITYAEHRRSP TVDSGDIRQA ARLLLPGLDC EPRQLKPECC FSSFRRLDAR
     AATERFNQDL GFRMLNCGRT DLISQAIEAL GPDGVNTMDD QGMTPLMYAC AAGDEAMVQM
     LIDAGANLDI QVPSHSPRHP SVHPDSRHWT SLTFAVLHGH ISVVQLLLDA GAHVEGSAVN
     SGEDSYAETP LQLASAAGNY ELVSLLLSRG ADPLLSMLEA NGMASSLHEE MNCFSHSAAH
     GHRNVLRKLL TQPQQAKADV LSLEEILAEG VEESDTSSQG SSEGPVRLSR TRTKALQEAM
     YYSAEHGYLD ITMELRALGV PWKLHIWIES LRTSFSQSRY SVVQSLLKDF SSIKEEEYNE
     ELVTEGLQLM FDILKTSKND SVLQQLATIF THCYGTSPIP SIPEIRKTLP ARLDPHFLNN
     KEMSDVTFLV EGKLFYAHKV LLVTASNRFK TLMTNKSEQD GDSSKTIEIS DIKYHIFQML
     MQYLYYGGTE SMEIPTADIL QLLSAANLFQ LDALQRHCEI LCSQTLSVES AVNTYKYAKI
     HNAPELALFC EGFFLKHMKA LLEQDAFRQL IYGRSSKVQG LDPLQDLQST LAERVHSVYV
     TSRV