TAFA1_HUMAN
ID TAFA1_HUMAN Reviewed; 133 AA.
AC Q7Z5A9; A8K0V3; Q8TCL8;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Chemokine-like protein TAFA-1 {ECO:0000305};
DE Flags: Precursor;
GN Name=TAFA1 {ECO:0000312|HGNC:HGNC:21587};
GN Synonyms=FAM19A1 {ECO:0000312|HGNC:HGNC:21587};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=15028294; DOI=10.1016/j.ygeno.2003.10.006;
RA Tom Tang Y., Emtage P., Funk W.D., Hu T., Arterburn M., Park E.E., Rupp F.;
RT "TAFA: a novel secreted family with conserved cysteine residues and
RT restricted expression in the brain.";
RL Genomics 83:727-734(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Amygdala, and Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Regulatory factor which is ligand for CMKLR2 and is involved
CC in the modulation of neural stem-cell proliferation and
CC differentiation. {ECO:0000250|UniProtKB:Q7TPG8}.
CC -!- INTERACTION:
CC Q7Z5A9; P53611: RABGGTB; NbExp=3; IntAct=EBI-10257895, EBI-536715;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15028294}.
CC -!- TISSUE SPECIFICITY: Brain-specific. {ECO:0000269|PubMed:15028294}.
CC -!- SIMILARITY: Belongs to the TAFA family. {ECO:0000305}.
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DR EMBL; AY325114; AAP92406.1; -; mRNA.
DR EMBL; AK289668; BAF82357.1; -; mRNA.
DR EMBL; AK290446; BAF83135.1; -; mRNA.
DR EMBL; AL713702; CAD28501.1; -; mRNA.
DR EMBL; BC025746; AAH25746.1; -; mRNA.
DR CCDS; CCDS54606.1; -.
DR RefSeq; NP_001239145.1; NM_001252216.1.
DR RefSeq; NP_998774.2; NM_213609.3.
DR RefSeq; XP_016861875.1; XM_017006386.1.
DR RefSeq; XP_016861876.1; XM_017006387.1.
DR AlphaFoldDB; Q7Z5A9; -.
DR BioGRID; 135906; 10.
DR IntAct; Q7Z5A9; 4.
DR STRING; 9606.ENSP00000418575; -.
DR iPTMnet; Q7Z5A9; -.
DR PhosphoSitePlus; Q7Z5A9; -.
DR BioMuta; FAM19A1; -.
DR DMDM; 74738719; -.
DR MassIVE; Q7Z5A9; -.
DR PaxDb; Q7Z5A9; -.
DR PeptideAtlas; Q7Z5A9; -.
DR PRIDE; Q7Z5A9; -.
DR Antibodypedia; 2681; 64 antibodies from 19 providers.
DR DNASU; 407738; -.
DR Ensembl; ENST00000478136.6; ENSP00000418575.1; ENSG00000183662.12.
DR Ensembl; ENST00000496687.1; ENSP00000417496.1; ENSG00000183662.12.
DR GeneID; 407738; -.
DR KEGG; hsa:407738; -.
DR MANE-Select; ENST00000478136.6; ENSP00000418575.1; NM_213609.4; NP_998774.2.
DR UCSC; uc003dne.4; human.
DR CTD; 407738; -.
DR DisGeNET; 407738; -.
DR GeneCards; TAFA1; -.
DR HGNC; HGNC:21587; TAFA1.
DR HPA; ENSG00000183662; Tissue enriched (brain).
DR MIM; 617495; gene.
DR neXtProt; NX_Q7Z5A9; -.
DR OpenTargets; ENSG00000183662; -.
DR PharmGKB; PA134907870; -.
DR VEuPathDB; HostDB:ENSG00000183662; -.
DR eggNOG; ENOG502RXI8; Eukaryota.
DR GeneTree; ENSGT00940000162607; -.
DR HOGENOM; CLU_126078_3_0_1; -.
DR InParanoid; Q7Z5A9; -.
DR OMA; RWWCEME; -.
DR OrthoDB; 1434087at2759; -.
DR PhylomeDB; Q7Z5A9; -.
DR TreeFam; TF331749; -.
DR PathwayCommons; Q7Z5A9; -.
DR SignaLink; Q7Z5A9; -.
DR BioGRID-ORCS; 407738; 9 hits in 1069 CRISPR screens.
DR ChiTaRS; FAM19A1; human.
DR GenomeRNAi; 407738; -.
DR Pharos; Q7Z5A9; Tbio.
DR PRO; PR:Q7Z5A9; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q7Z5A9; protein.
DR Bgee; ENSG00000183662; Expressed in middle temporal gyrus and 132 other tissues.
DR ExpressionAtlas; Q7Z5A9; baseline and differential.
DR Genevisible; Q7Z5A9; HS.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:LIFEdb.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0048018; F:receptor ligand activity; ISS:UniProtKB.
DR GO; GO:0014016; P:neuroblast differentiation; ISS:UniProtKB.
DR GO; GO:1902692; P:regulation of neuroblast proliferation; ISS:UniProtKB.
DR GO; GO:0010469; P:regulation of signaling receptor activity; ISS:UniProtKB.
DR InterPro; IPR020350; Chemokine-like_TAFA.
DR Pfam; PF12020; TAFA; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..133
FT /note="Chemokine-like protein TAFA-1"
FT /id="PRO_0000042721"
FT CONFLICT 92
FT /note="G -> W (in Ref. 3; CAD28501)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 133 AA; 14901 MW; C5DD1C7E5F997386 CRC64;
MAMVSAMSWV LYLWISACAM LLCHGSLQHT FQQHHLHRPE GGTCEVIAAH RCCNKNRIEE
RSQTVKCSCL PGKVAGTTRN RPSCVDASIV IGKWWCEMEP CLEGEECKTL PDNSGWMCAT
GNKIKTTRIH PRT
