TAFA1_MOUSE
ID TAFA1_MOUSE Reviewed; 133 AA.
AC Q7TPG8; A2RSN6;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Chemokine-like protein TAFA-1 {ECO:0000305};
DE Flags: Precursor;
GN Name=Tafa1; Synonyms=Fam19a1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=15028294; DOI=10.1016/j.ygeno.2003.10.006;
RA Tom Tang Y., Emtage P., Funk W.D., Hu T., Arterburn M., Park E.E., Rupp F.;
RT "TAFA: a novel secreted family with conserved cysteine residues and
RT restricted expression in the brain.";
RL Genomics 83:727-734(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, SUBCELLULAR LOCATION,
RP AND INDUCTION BY INJURY.
RX PubMed=29799787; DOI=10.1096/fj.201800020rrr;
RA Zheng C., Chen D., Zhang Y., Bai Y., Huang S., Zheng D., Liang W., She S.,
RA Peng X., Wang P., Mo X., Song Q., Lv P., Huang J., Ye R.D., Wang Y.;
RT "FAM19A1 is a new ligand for GPR1 that modulates neural stem-cell
RT proliferation and differentiation.";
RL FASEB J. 0:0-0(2018).
CC -!- FUNCTION: Regulatory factor which is ligand for CMKLR2 and is involved
CC in the modulation of neural stem-cell proliferation and
CC differentiation. {ECO:0000269|PubMed:29799787}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29799787}.
CC -!- TISSUE SPECIFICITY: Expressed in the hippocampus and detected also in
CC the cortex (at protein level). {ECO:0000269|PubMed:29799787}.
CC -!- DEVELOPMENTAL STAGE: Detected as early as 12.5 dpc, expression peaks
CC between postnatal day 1 and day 7 and decreases at week 8 after birth
CC (at protein level). {ECO:0000269|PubMed:29799787}.
CC -!- INDUCTION: Expression decreases upon brain injury.
CC {ECO:0000269|PubMed:29799787}.
CC -!- SIMILARITY: Belongs to the TAFA family. {ECO:0000305}.
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DR EMBL; AY325120; AAP92412.1; -; mRNA.
DR EMBL; BC132179; AAI32180.1; -; mRNA.
DR EMBL; BC132181; AAI32182.1; -; mRNA.
DR CCDS; CCDS39574.1; -.
DR RefSeq; NP_877960.1; NM_182808.3.
DR AlphaFoldDB; Q7TPG8; -.
DR STRING; 10090.ENSMUSP00000074589; -.
DR PhosphoSitePlus; Q7TPG8; -.
DR PaxDb; Q7TPG8; -.
DR PRIDE; Q7TPG8; -.
DR ProteomicsDB; 275513; -.
DR Antibodypedia; 2681; 64 antibodies from 19 providers.
DR DNASU; 320265; -.
DR Ensembl; ENSMUST00000075080; ENSMUSP00000074589; ENSMUSG00000059187.
DR Ensembl; ENSMUST00000122120; ENSMUSP00000113152; ENSMUSG00000059187.
DR GeneID; 320265; -.
DR KEGG; mmu:320265; -.
DR UCSC; uc009dae.2; mouse.
DR CTD; 407738; -.
DR MGI; MGI:2443695; Tafa1.
DR VEuPathDB; HostDB:ENSMUSG00000059187; -.
DR eggNOG; ENOG502RXI8; Eukaryota.
DR GeneTree; ENSGT00940000162607; -.
DR HOGENOM; CLU_126078_3_0_1; -.
DR InParanoid; Q7TPG8; -.
DR OMA; RWWCEME; -.
DR OrthoDB; 1434087at2759; -.
DR PhylomeDB; Q7TPG8; -.
DR TreeFam; TF331749; -.
DR BioGRID-ORCS; 320265; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Fam19a1; mouse.
DR PRO; PR:Q7TPG8; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q7TPG8; protein.
DR Bgee; ENSMUSG00000059187; Expressed in piriform cortex and 94 other tissues.
DR Genevisible; Q7TPG8; MM.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR GO; GO:0048018; F:receptor ligand activity; IDA:UniProtKB.
DR GO; GO:0014016; P:neuroblast differentiation; IDA:UniProtKB.
DR GO; GO:1902692; P:regulation of neuroblast proliferation; IDA:UniProtKB.
DR GO; GO:0010469; P:regulation of signaling receptor activity; IDA:UniProtKB.
DR InterPro; IPR020350; Chemokine-like_TAFA.
DR Pfam; PF12020; TAFA; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..133
FT /note="Chemokine-like protein TAFA-1"
FT /id="PRO_0000042722"
SQ SEQUENCE 133 AA; 14873 MW; C5C20C764F8E7386 CRC64;
MAMVSAMSWA LYLWISACAM LLCHGSLQHT FQQHHLHRPE GGTCEVIAAH RCCNKNRIEE
RSQTVKCSCL PGKVAGTTRN RPSCVDASIV IGKWWCEMEP CLEGEECKTL PDNSGWMCAT
GNKIKTTRIH PRT
