TAFA2_HUMAN
ID TAFA2_HUMAN Reviewed; 131 AA.
AC Q8N3H0; B3KVV4; Q4G0R9; Q68DK0; Q6GTX6;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Chemokine-like protein TAFA-2 {ECO:0000305};
DE Flags: Precursor;
GN Name=TAFA2 {ECO:0000312|HGNC:HGNC:21589};
GN Synonyms=FAM19A2 {ECO:0000312|HGNC:HGNC:21589};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND SUBCELLULAR
RP LOCATION.
RX PubMed=15028294; DOI=10.1016/j.ygeno.2003.10.006;
RA Tom Tang Y., Emtage P., Funk W.D., Hu T., Arterburn M., Park E.E., Rupp F.;
RT "TAFA: a novel secreted family with conserved cysteine residues and
RT restricted expression in the brain.";
RL Genomics 83:727-734(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Amygdala, and Retina;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Has a role as neurotrophic factor involved in neuronal
CC survival and neurobiological functions. {ECO:0000250|UniProtKB:Q7TPG7}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15028294}. Nucleus
CC {ECO:0000250|UniProtKB:Q7TPG7}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N3H0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N3H0-2; Sequence=VSP_016066;
CC -!- TISSUE SPECIFICITY: Brain-specific. {ECO:0000269|PubMed:15028294}.
CC -!- SIMILARITY: Belongs to the TAFA family. {ECO:0000305}.
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DR EMBL; AY325115; AAP92407.1; -; mRNA.
DR EMBL; AK123580; BAG53916.1; -; mRNA.
DR EMBL; AL834160; CAD38865.1; -; mRNA.
DR EMBL; CR749367; CAH18220.1; -; mRNA.
DR EMBL; CH471054; EAW97100.1; -; Genomic_DNA.
DR EMBL; BC028403; AAH28403.1; -; mRNA.
DR EMBL; BC040286; AAH40286.1; -; mRNA.
DR CCDS; CCDS8962.1; -. [Q8N3H0-1]
DR RefSeq; NP_848634.1; NM_178539.4. [Q8N3H0-1]
DR RefSeq; XP_006719433.1; XM_006719370.2.
DR RefSeq; XP_011536574.1; XM_011538272.1. [Q8N3H0-1]
DR RefSeq; XP_011536576.1; XM_011538274.1.
DR AlphaFoldDB; Q8N3H0; -.
DR BioGRID; 130801; 46.
DR STRING; 9606.ENSP00000393987; -.
DR PhosphoSitePlus; Q8N3H0; -.
DR BioMuta; FAM19A2; -.
DR DMDM; 74714846; -.
DR MassIVE; Q8N3H0; -.
DR MaxQB; Q8N3H0; -.
DR PaxDb; Q8N3H0; -.
DR PeptideAtlas; Q8N3H0; -.
DR PRIDE; Q8N3H0; -.
DR ProteomicsDB; 71803; -. [Q8N3H0-1]
DR Antibodypedia; 56101; 34 antibodies from 15 providers.
DR DNASU; 338811; -.
DR Ensembl; ENST00000416284.8; ENSP00000393987.3; ENSG00000198673.11. [Q8N3H0-1]
DR Ensembl; ENST00000550003.1; ENSP00000449457.1; ENSG00000198673.11. [Q8N3H0-2]
DR Ensembl; ENST00000551619.5; ENSP00000447305.1; ENSG00000198673.11. [Q8N3H0-1]
DR GeneID; 338811; -.
DR KEGG; hsa:338811; -.
DR MANE-Select; ENST00000416284.8; ENSP00000393987.3; NM_178539.5; NP_848634.1.
DR UCSC; uc001sqw.4; human. [Q8N3H0-1]
DR CTD; 338811; -.
DR DisGeNET; 338811; -.
DR GeneCards; TAFA2; -.
DR HGNC; HGNC:21589; TAFA2.
DR HPA; ENSG00000198673; Group enriched (brain, seminal vesicle).
DR MIM; 617496; gene.
DR neXtProt; NX_Q8N3H0; -.
DR OpenTargets; ENSG00000198673; -.
DR PharmGKB; PA134974674; -.
DR VEuPathDB; HostDB:ENSG00000198673; -.
DR eggNOG; ENOG502S0VQ; Eukaryota.
DR GeneTree; ENSGT00940000161214; -.
DR HOGENOM; CLU_126078_1_0_1; -.
DR InParanoid; Q8N3H0; -.
DR OMA; KMNIRTQ; -.
DR OrthoDB; 1371619at2759; -.
DR PhylomeDB; Q8N3H0; -.
DR TreeFam; TF331749; -.
DR PathwayCommons; Q8N3H0; -.
DR BioGRID-ORCS; 338811; 6 hits in 1070 CRISPR screens.
DR ChiTaRS; FAM19A2; human.
DR GenomeRNAi; 338811; -.
DR Pharos; Q8N3H0; Tbio.
DR PRO; PR:Q8N3H0; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q8N3H0; protein.
DR Bgee; ENSG00000198673; Expressed in secondary oocyte and 135 other tissues.
DR ExpressionAtlas; Q8N3H0; baseline and differential.
DR Genevisible; Q8N3H0; HS.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0048018; F:receptor ligand activity; IBA:GO_Central.
DR GO; GO:0007613; P:memory; ISS:UniProtKB.
DR GO; GO:0008542; P:visual learning; ISS:UniProtKB.
DR InterPro; IPR020350; Chemokine-like_TAFA.
DR Pfam; PF12020; TAFA; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Nucleus; Reference proteome; Signal.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..131
FT /note="Chemokine-like protein TAFA-2"
FT /id="PRO_0000042723"
FT VAR_SEQ 1..97
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_016066"
FT CONFLICT 52
FT /note="C -> Y (in Ref. 5; AAH28403)"
FT /evidence="ECO:0000305"
FT CONFLICT 67
FT /note="C -> Y (in Ref. 5; AAH28403)"
FT /evidence="ECO:0000305"
FT CONFLICT 129..131
FT /note="VTH -> ANV (in Ref. 3; CAH18220)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 131 AA; 14620 MW; 6D7E0DB2E59965E4 CRC64;
MSKRYLQKAT KGKLLIIIFI VTLWGKVVSS ANHHKAHHVK TGTCEVVALH RCCNKNKIEE
RSQTVKCSCF PGQVAGTTRA APSCVDASIV EQKWWCHMQP CLEGEECKVL PDRKGWSCSS
GNKVKTTRVT H
