ID   TAFA2_MOUSE             Reviewed;         131 AA.
AC   Q7TPG7; Q5M9Q3;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Chemokine-like protein TAFA-2 {ECO:0000305};
DE   Flags: Precursor;
GN   Name=Tafa2; Synonyms=Fam19a2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=15028294; DOI=10.1016/j.ygeno.2003.10.006;
RA   Tom Tang Y., Emtage P., Funk W.D., Hu T., Arterburn M., Park E.E., Rupp F.;
RT   "TAFA: a novel secreted family with conserved cysteine residues and
RT   restricted expression in the brain.";
RL   Genomics 83:727-734(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Hippocampus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [5]
RP   FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP   AND SUBCELLULAR LOCATION.
RX   PubMed=30137205; DOI=10.1093/abbs/gmy097;
RA   Wang X., Shen C., Chen X., Wang J., Cui X., Wang Y., Zhang H., Tang L.,
RA   Lu S., Fei J., Wang Z.;
RT   "Tafa-2 plays an essential role in neuronal survival and neurobiological
RT   function in mice.";
RL   Acta Biochim. Biophys. Sin. 50:984-995(2018).
CC   -!- FUNCTION: Has a role as neurotrophic factor involved in neuronal
CC       survival and neurobiological functions. {ECO:0000269|PubMed:30137205}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:30137205}. Nucleus
CC       {ECO:0000269|PubMed:30137205}.
CC   -!- TISSUE SPECIFICITY: Mainly expressed in different brain regions,
CC       including cortex, amygdala and hippocampus (at protein level)
CC       (PubMed:30137205). Expressed by neurons and astrocytes
CC       (PubMed:30137205). {ECO:0000269|PubMed:30137205}.
CC   -!- DEVELOPMENTAL STAGE: Expressed as early as 13.5 dpc, increases and
CC       peaks at 2 weeks after birth and is highly expressed until adulthood.
CC       {ECO:0000269|PubMed:30137205}.
CC   -!- DISRUPTION PHENOTYPE: Mutant mice grow and develop normally but exhibit
CC       impairments in spatial learning and memory and impairments in
CC       short- and long-term memory, accompanied with increased level of
CC       anxiety-like behaviors in open-field test. They also show decreased
CC       level of depression-like behaviors in forced-swim test and tail-
CC       suspension test (PubMed:30137205). They show neuronal loss, defects in
CC       dendritic and synaptic morphology, and apoptosis in the brain
CC       (PubMed:30137205). {ECO:0000269|PubMed:30137205}.
CC   -!- SIMILARITY: Belongs to the TAFA family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH27082.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AY325121; AAP92413.1; -; mRNA.
DR   EMBL; AK164201; BAE37679.1; -; mRNA.
DR   EMBL; BC027082; AAH27082.1; ALT_INIT; mRNA.
DR   CCDS; CCDS88096.1; -.
DR   RefSeq; NP_001239316.1; NM_001252387.1.
DR   RefSeq; NP_877959.2; NM_182807.3.
DR   AlphaFoldDB; Q7TPG7; -.
DR   STRING; 10090.ENSMUSP00000050199; -.
DR   PhosphoSitePlus; Q7TPG7; -.
DR   PaxDb; Q7TPG7; -.
DR   PRIDE; Q7TPG7; -.
DR   ProteomicsDB; 277017; -.
DR   Antibodypedia; 56101; 34 antibodies from 15 providers.
DR   DNASU; 268354; -.
DR   Ensembl; ENSMUST00000238972; ENSMUSP00000159016; ENSMUSG00000044071.
DR   GeneID; 268354; -.
DR   KEGG; mmu:268354; -.
DR   UCSC; uc007hgu.2; mouse.
DR   CTD; 338811; -.
DR   MGI; MGI:2143691; Tafa2.
DR   VEuPathDB; HostDB:ENSMUSG00000044071; -.
DR   eggNOG; ENOG502S0VQ; Eukaryota.
DR   GeneTree; ENSGT00940000161214; -.
DR   InParanoid; Q7TPG7; -.
DR   OMA; KMNIRTQ; -.
DR   OrthoDB; 1371619at2759; -.
DR   PhylomeDB; Q7TPG7; -.
DR   TreeFam; TF331749; -.
DR   BioGRID-ORCS; 268354; 2 hits in 73 CRISPR screens.
DR   ChiTaRS; Tafa2; mouse.
DR   PRO; PR:Q7TPG7; -.
DR   Proteomes; UP000000589; Chromosome 10.
DR   RNAct; Q7TPG7; protein.
DR   Bgee; ENSMUSG00000044071; Expressed in piriform cortex and 139 other tissues.
DR   ExpressionAtlas; Q7TPG7; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0048018; F:receptor ligand activity; IBA:GO_Central.
DR   GO; GO:0007613; P:memory; IMP:UniProtKB.
DR   GO; GO:0008542; P:visual learning; IMP:UniProtKB.
DR   InterPro; IPR020350; Chemokine-like_TAFA.
DR   Pfam; PF12020; TAFA; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome; Signal.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..131
FT                   /note="Chemokine-like protein TAFA-2"
FT                   /id="PRO_0000042724"
SQ   SEQUENCE   131 AA;  14647 MW;  FE70D61916A95F47 CRC64;
     MNKRYLQKAT QGKLLIIIFI VTLWGKAVSS ANHHKAHHVR TGTCEVVALH RCCNKNKIEE
     RSQTVKCSCF PGQVAGTTRA APSCVDASIV EQKWWCHMQP CLEGEECKVL PDRKGWSCSS
     GNKVKTTRVT H