TAFA3_HUMAN
ID TAFA3_HUMAN Reviewed; 133 AA.
AC Q7Z5A8; B7ZLU0; Q2M1P9; Q7Z5A6;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Chemokine-like protein TAFA-3 {ECO:0000305};
DE Flags: Precursor;
GN Name=TAFA3 {ECO:0000312|HGNC:HGNC:21590};
GN Synonyms=FAM19A3 {ECO:0000312|HGNC:HGNC:21590};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, AND
RP SUBCELLULAR LOCATION.
RX PubMed=15028294; DOI=10.1016/j.ygeno.2003.10.006;
RA Tom Tang Y., Emtage P., Funk W.D., Hu T., Arterburn M., Park E.E., Rupp F.;
RT "TAFA: a novel secreted family with conserved cysteine residues and
RT restricted expression in the brain.";
RL Genomics 83:727-734(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=25595455; DOI=10.1016/j.febslet.2015.01.003;
RA Shao Y., Deng T., Zhang T., Li P., Wang Y.;
RT "FAM19A3, a novel secreted protein, modulates the microglia/macrophage
RT polarization dynamics and ameliorates cerebral ischemia.";
RL FEBS Lett. 589:467-475(2015).
CC -!- FUNCTION: Plays a role in the regulation of microglia polarization.
CC {ECO:0000250|UniProtKB:Q7TPG6}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15028294,
CC ECO:0000269|PubMed:25595455}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=TAFA3;
CC IsoId=Q7Z5A8-1; Sequence=Displayed;
CC Name=2; Synonyms=TAFA3.2;
CC IsoId=Q7Z5A8-2; Sequence=VSP_016067;
CC -!- TISSUE SPECIFICITY: Brain-specific. {ECO:0000269|PubMed:15028294,
CC ECO:0000269|PubMed:25595455}.
CC -!- SIMILARITY: Belongs to the TAFA family. {ECO:0000305}.
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DR EMBL; AY325116; AAP92408.1; -; mRNA.
DR EMBL; AY325119; AAP92411.1; -; mRNA.
DR EMBL; AL603832; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471122; EAW56548.1; -; Genomic_DNA.
DR EMBL; CH471122; EAW56549.1; -; Genomic_DNA.
DR EMBL; BC112268; AAI12269.1; -; mRNA.
DR EMBL; BC117479; AAI17480.1; -; mRNA.
DR EMBL; BC144043; AAI44044.1; -; mRNA.
DR CCDS; CCDS30806.1; -. [Q7Z5A8-2]
DR CCDS; CCDS856.1; -. [Q7Z5A8-1]
DR RefSeq; NP_001004440.1; NM_001004440.1. [Q7Z5A8-2]
DR RefSeq; NP_877436.1; NM_182759.2. [Q7Z5A8-1]
DR RefSeq; XP_005270823.1; XM_005270766.3. [Q7Z5A8-1]
DR RefSeq; XP_006710645.1; XM_006710582.3. [Q7Z5A8-2]
DR AlphaFoldDB; Q7Z5A8; -.
DR BioGRID; 129885; 84.
DR IntAct; Q7Z5A8; 74.
DR STRING; 9606.ENSP00000358644; -.
DR iPTMnet; Q7Z5A8; -.
DR PhosphoSitePlus; Q7Z5A8; -.
DR BioMuta; FAM19A3; -.
DR DMDM; 74750123; -.
DR MassIVE; Q7Z5A8; -.
DR PaxDb; Q7Z5A8; -.
DR PeptideAtlas; Q7Z5A8; -.
DR PRIDE; Q7Z5A8; -.
DR Antibodypedia; 33837; 108 antibodies from 18 providers.
DR DNASU; 284467; -.
DR Ensembl; ENST00000361886.4; ENSP00000355042.3; ENSG00000184599.14. [Q7Z5A8-1]
DR Ensembl; ENST00000369630.7; ENSP00000358644.3; ENSG00000184599.14. [Q7Z5A8-2]
DR GeneID; 284467; -.
DR KEGG; hsa:284467; -.
DR MANE-Select; ENST00000361886.4; ENSP00000355042.3; NM_182759.3; NP_877436.1.
DR UCSC; uc001ecu.4; human. [Q7Z5A8-1]
DR CTD; 284467; -.
DR DisGeNET; 284467; -.
DR GeneCards; TAFA3; -.
DR HGNC; HGNC:21590; TAFA3.
DR HPA; ENSG00000184599; Group enriched (adrenal gland, retina).
DR MIM; 617497; gene.
DR neXtProt; NX_Q7Z5A8; -.
DR OpenTargets; ENSG00000184599; -.
DR PharmGKB; PA134899352; -.
DR VEuPathDB; HostDB:ENSG00000184599; -.
DR eggNOG; ENOG502SVHN; Eukaryota.
DR GeneTree; ENSGT00940000155644; -.
DR HOGENOM; CLU_126078_0_0_1; -.
DR InParanoid; Q7Z5A8; -.
DR OMA; ICVELIY; -.
DR OrthoDB; 1403365at2759; -.
DR PhylomeDB; Q7Z5A8; -.
DR TreeFam; TF331749; -.
DR PathwayCommons; Q7Z5A8; -.
DR SignaLink; Q7Z5A8; -.
DR BioGRID-ORCS; 284467; 7 hits in 1071 CRISPR screens.
DR GenomeRNAi; 284467; -.
DR Pharos; Q7Z5A8; Tdark.
DR PRO; PR:Q7Z5A8; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q7Z5A8; protein.
DR Bgee; ENSG00000184599; Expressed in left testis and 72 other tissues.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0048018; F:receptor ligand activity; IBA:GO_Central.
DR GO; GO:1903979; P:negative regulation of microglial cell activation; ISS:UniProtKB.
DR GO; GO:0014016; P:neuroblast differentiation; IBA:GO_Central.
DR GO; GO:1903980; P:positive regulation of microglial cell activation; ISS:UniProtKB.
DR GO; GO:1902692; P:regulation of neuroblast proliferation; IBA:GO_Central.
DR InterPro; IPR020350; Chemokine-like_TAFA.
DR Pfam; PF12020; TAFA; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Secreted; Signal.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..133
FT /note="Chemokine-like protein TAFA-3"
FT /id="PRO_0000042726"
FT VAR_SEQ 89..133
FT /note="ASIVLQRWWCQMEPCLPGEECKVLPDLSGWSCSSGHKVKTTKVTR -> DLL
FT LAAHCARRDPRAALRLLLPQPPSSCRDGGVRWSPACRGRSVRCSRTCRDGAAAVDTKSK
FT PPRSHDSSWGSRPGQERLD (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15028294,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_016067"
SQ SEQUENCE 133 AA; 14776 MW; C074C703817D008D CRC64;
MSERVERNWS TGGWLLALCL AWLWTHLTLA ALQPPTATVL VQQGTCEVIA AHRCCNRNRI
EERSQTVKCS CFSGQVAGTT RAKPSCVDAS IVLQRWWCQM EPCLPGEECK VLPDLSGWSC
SSGHKVKTTK VTR
