TAFA3_MOUSE
ID TAFA3_MOUSE Reviewed; 132 AA.
AC Q7TPG6; Q147Z7;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Chemokine-like protein TAFA-3 {ECO:0000305};
DE Flags: Precursor;
GN Name=Tafa3; Synonyms=Fam19a3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=15028294; DOI=10.1016/j.ygeno.2003.10.006;
RA Tom Tang Y., Emtage P., Funk W.D., Hu T., Arterburn M., Park E.E., Rupp F.;
RT "TAFA: a novel secreted family with conserved cysteine residues and
RT restricted expression in the brain.";
RL Genomics 83:727-734(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=22426341; DOI=10.1016/j.ygcen.2012.02.016;
RA Fischer C., Christ E., Korf H.W., von Gall C.;
RT "Tafa-3 encoding for a secretory peptide is expressed in the mouse pars
RT tuberalis and is affected by melatonin 1 receptor deficiency.";
RL Gen. Comp. Endocrinol. 177:98-103(2012).
RN [4]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, AND FUNCTION.
RX PubMed=25595455; DOI=10.1016/j.febslet.2015.01.003;
RA Shao Y., Deng T., Zhang T., Li P., Wang Y.;
RT "FAM19A3, a novel secreted protein, modulates the microglia/macrophage
RT polarization dynamics and ameliorates cerebral ischemia.";
RL FEBS Lett. 589:467-475(2015).
CC -!- FUNCTION: Plays a role in the regulation of microglia polarization.
CC {ECO:0000269|PubMed:25595455}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22426341,
CC ECO:0000269|PubMed:25595455}.
CC -!- TISSUE SPECIFICITY: Highly expressed in brain, in regions such as the
CC hippocampus, the habenular, thalamic nuclei and hypophysial pars
CC tuberalis (PubMed:25595455). Expression levels in the hypophysial pars
CC tuberalis vary between day and night: they are low at mid-day and high
CC at mid-night. The expression in the other regions do not display a
CC day/night difference (PubMed:22426341). {ECO:0000269|PubMed:22426341,
CC ECO:0000269|PubMed:25595455}.
CC -!- INDUCTION: By ischemia. Up-regulated in the microglia in the middle
CC cerebral artery occlusion (MCAO), expression reduced back to control
CC level at 14 days after MCAO. {ECO:0000269|PubMed:25595455}.
CC -!- SIMILARITY: Belongs to the TAFA family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY325122; AAP92414.1; -; mRNA.
DR EMBL; BC118531; AAI18532.1; -; mRNA.
DR CCDS; CCDS51032.1; -.
DR RefSeq; NP_899047.1; NM_183224.3.
DR RefSeq; XP_017175115.1; XM_017319626.1.
DR AlphaFoldDB; Q7TPG6; -.
DR STRING; 10090.ENSMUSP00000123514; -.
DR iPTMnet; Q7TPG6; -.
DR PhosphoSitePlus; Q7TPG6; -.
DR PaxDb; Q7TPG6; -.
DR PRIDE; Q7TPG6; -.
DR ProteomicsDB; 275724; -.
DR Antibodypedia; 33837; 108 antibodies from 18 providers.
DR Ensembl; ENSMUST00000139783; ENSMUSP00000123514; ENSMUSG00000055865.
DR GeneID; 329731; -.
DR KEGG; mmu:329731; -.
DR UCSC; uc008quj.2; mouse.
DR CTD; 284467; -.
DR MGI; MGI:3046463; Tafa3.
DR VEuPathDB; HostDB:ENSMUSG00000055865; -.
DR eggNOG; ENOG502S0M0; Eukaryota.
DR GeneTree; ENSGT00940000155644; -.
DR HOGENOM; CLU_126078_1_0_1; -.
DR InParanoid; Q7TPG6; -.
DR OMA; RWWCHME; -.
DR OrthoDB; 1371619at2759; -.
DR PhylomeDB; Q7TPG6; -.
DR TreeFam; TF331749; -.
DR BioGRID-ORCS; 329731; 1 hit in 70 CRISPR screens.
DR ChiTaRS; Fam19a3; mouse.
DR PRO; PR:Q7TPG6; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q7TPG6; protein.
DR Bgee; ENSMUSG00000055865; Expressed in lumbar dorsal root ganglion and 68 other tissues.
DR Genevisible; Q7TPG6; MM.
DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR GO; GO:0048018; F:receptor ligand activity; IBA:GO_Central.
DR GO; GO:1903979; P:negative regulation of microglial cell activation; IDA:MGI.
DR GO; GO:0014016; P:neuroblast differentiation; IBA:GO_Central.
DR GO; GO:1903980; P:positive regulation of microglial cell activation; IDA:MGI.
DR GO; GO:1902692; P:regulation of neuroblast proliferation; IBA:GO_Central.
DR InterPro; IPR020350; Chemokine-like_TAFA.
DR Pfam; PF12020; TAFA; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..132
FT /note="Chemokine-like protein TAFA-3"
FT /id="PRO_0000042727"
SQ SEQUENCE 132 AA; 14426 MW; 2D60C45AE1BA3F00 CRC64;
MERPTSNWSA GSWVLALCLA WLWTCPASAS LQPPTSAVLV KQGTCEVIAA HRCCNRNRIE
ERSQTVKCSC LSGQVAGTTR AKPSCVDASI VLQKWWCQME PCLLGEECKV LPDLSGWSCS
SGHKVKTTKV TR
