TAFA4_HUMAN
ID TAFA4_HUMAN Reviewed; 140 AA.
AC Q96LR4; A8MVT2;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Chemokine-like protein TAFA-4 {ECO:0000305};
DE Flags: Precursor;
GN Name=TAFA4 {ECO:0000312|HGNC:HGNC:21591};
GN Synonyms=FAM19A4 {ECO:0000312|HGNC:HGNC:21591};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=15028294; DOI=10.1016/j.ygeno.2003.10.006;
RA Tom Tang Y., Emtage P., Funk W.D., Hu T., Arterburn M., Park E.E., Rupp F.;
RT "TAFA: a novel secreted family with conserved cysteine residues and
RT restricted expression in the brain.";
RL Genomics 83:727-734(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=25109685; DOI=10.1038/cmi.2014.61;
RA Wang W., Li T., Wang X., Yuan W., Cheng Y., Zhang H., Xu E., Zhang Y.,
RA Shi S., Ma D., Han W.;
RT "FAM19A4 is a novel cytokine ligand of formyl peptide receptor 1 (FPR1) and
RT is able to promote the migration and phagocytosis of macrophages.";
RL Cell. Mol. Immunol. 12:615-624(2015).
CC -!- FUNCTION: Modulates injury-induced and chemical pain hypersensitivity
CC (By similarity). Ligand of FPR1, can chemoattract macrophages, promote
CC phagocytosis and increase ROS release (PubMed:25109685).
CC {ECO:0000250|UniProtKB:Q7TPG5, ECO:0000269|PubMed:25109685}.
CC -!- INTERACTION:
CC Q96LR4; Q92624: APPBP2; NbExp=3; IntAct=EBI-10290841, EBI-743771;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15028294,
CC ECO:0000269|PubMed:25109685}.
CC -!- TISSUE SPECIFICITY: Expressed in brain (PubMed:15028294). Expressed in
CC LPS-stimulated monocytes and macrophages, especially in polarized M1
CC (PubMed:25109685). {ECO:0000269|PubMed:15028294,
CC ECO:0000269|PubMed:25109685}.
CC -!- SIMILARITY: Belongs to the TAFA family. {ECO:0000305}.
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DR EMBL; AY325117; AAP92409.1; -; mRNA.
DR EMBL; AK057890; BAB71606.1; -; mRNA.
DR EMBL; AC096922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC104166; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC109587; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471055; EAW65463.1; -; Genomic_DNA.
DR EMBL; BC031566; AAH31566.1; -; mRNA.
DR CCDS; CCDS2907.1; -.
DR RefSeq; NP_001005527.1; NM_001005527.2.
DR RefSeq; NP_872328.1; NM_182522.4.
DR AlphaFoldDB; Q96LR4; -.
DR BioGRID; 127394; 82.
DR IntAct; Q96LR4; 51.
DR STRING; 9606.ENSP00000295569; -.
DR BioMuta; FAM19A4; -.
DR DMDM; 74732248; -.
DR MassIVE; Q96LR4; -.
DR MaxQB; Q96LR4; -.
DR PaxDb; Q96LR4; -.
DR PeptideAtlas; Q96LR4; -.
DR PRIDE; Q96LR4; -.
DR Antibodypedia; 46378; 108 antibodies from 14 providers.
DR DNASU; 151647; -.
DR Ensembl; ENST00000295569.12; ENSP00000295569.7; ENSG00000163377.16.
DR GeneID; 151647; -.
DR KEGG; hsa:151647; -.
DR MANE-Select; ENST00000295569.12; ENSP00000295569.7; NM_182522.5; NP_872328.1.
DR UCSC; uc021xag.2; human.
DR CTD; 151647; -.
DR DisGeNET; 151647; -.
DR GeneCards; TAFA4; -.
DR HGNC; HGNC:21591; TAFA4.
DR HPA; ENSG00000163377; Group enriched (adrenal gland, brain, retina, stomach).
DR MIM; 617498; gene.
DR neXtProt; NX_Q96LR4; -.
DR OpenTargets; ENSG00000163377; -.
DR PharmGKB; PA134873006; -.
DR VEuPathDB; HostDB:ENSG00000163377; -.
DR eggNOG; ENOG502RZN9; Eukaryota.
DR GeneTree; ENSGT00940000159882; -.
DR HOGENOM; CLU_126078_3_0_1; -.
DR InParanoid; Q96LR4; -.
DR OMA; HWVFLAY; -.
DR OrthoDB; 1371619at2759; -.
DR PhylomeDB; Q96LR4; -.
DR TreeFam; TF331749; -.
DR PathwayCommons; Q96LR4; -.
DR SignaLink; Q96LR4; -.
DR BioGRID-ORCS; 151647; 12 hits in 1065 CRISPR screens.
DR ChiTaRS; FAM19A4; human.
DR GenomeRNAi; 151647; -.
DR Pharos; Q96LR4; Tbio.
DR PRO; PR:Q96LR4; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q96LR4; protein.
DR Bgee; ENSG00000163377; Expressed in oocyte and 71 other tissues.
DR ExpressionAtlas; Q96LR4; baseline and differential.
DR Genevisible; Q96LR4; HS.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0048018; F:receptor ligand activity; ISS:UniProtKB.
DR GO; GO:0048246; P:macrophage chemotaxis; ISS:UniProtKB.
DR GO; GO:0006909; P:phagocytosis; ISS:UniProtKB.
DR GO; GO:0042391; P:regulation of membrane potential; IEA:Ensembl.
DR GO; GO:0051930; P:regulation of sensory perception of pain; IEA:Ensembl.
DR GO; GO:0010469; P:regulation of signaling receptor activity; ISS:UniProtKB.
DR GO; GO:0042554; P:superoxide anion generation; ISS:UniProtKB.
DR InterPro; IPR020350; Chemokine-like_TAFA.
DR Pfam; PF12020; TAFA; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..35
FT /evidence="ECO:0000255"
FT CHAIN 36..140
FT /note="Chemokine-like protein TAFA-4"
FT /id="PRO_0000042728"
SQ SEQUENCE 140 AA; 15682 MW; 173254FBBB526009 CRC64;
MRSPRMRVCA KSVLLSHWLF LAYVLMVCCK LMSASSQHLR GHAGHHQIKQ GTCEVVAVHR
CCNKNRIEER SQTVKCSCFP GQVAGTTRAQ PSCVEASIVI QKWWCHMNPC LEGEDCKVLP
DYSGWSCSSG NKVKTTKVTR
