ID   TAFA4_MACFA             Reviewed;         140 AA.
AC   Q9N0D3; Q95K92;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Chemokine-like protein TAFA-4 {ECO:0000305};
DE   Flags: Precursor;
GN   Name=TAFA4; Synonyms=FAM19A4; ORFNames=QccE-12230, QmoA-12486;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RX   PubMed=11574149; DOI=10.1016/s0378-1119(01)00665-5;
RA   Osada N., Hida M., Kususda J., Tanuma R., Iseki K., Hirata M., Suto Y.,
RA   Hirai M., Terao K., Suzuki Y., Sugano S., Hashimoto K.;
RT   "Assignment of 118 novel cDNAs of cynomolgus monkey brain to human
RT   chromosomes.";
RL   Gene 275:31-37(2001).
RN   [2]
RP   ERRATUM OF PUBMED:11574149.
RA   Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirata M., Suto Y.,
RA   Hirai M., Terao K., Suzuki Y., Sugano S., Hashimoto K., Kususda J.;
RL   Gene 278:267-267(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Medulla oblongata;
RX   PubMed=11806829; DOI=10.1186/gb-2001-3-1-research0006;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Hirai M., Terao K.,
RA   Suzuki Y., Sugano S., Hashimoto K.;
RT   "Prediction of unidentified human genes on the basis of sequence similarity
RT   to novel cDNAs from cynomolgus monkey brain.";
RL   Genome Biol. 3:RESEARCH0006.1-RESEARCH0006.5(2002).
CC   -!- FUNCTION: Modulates injury-induced and chemical pain hypersensitivity.
CC       Ligand of FPR1, can chemoattract macrophages, promote phagocytosis and
CC       increase ROS release. {ECO:0000250|UniProtKB:Q7TPG5}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q96LR4}.
CC   -!- SIMILARITY: Belongs to the TAFA family. {ECO:0000305}.
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DR   EMBL; AB045997; BAB01579.1; -; mRNA.
DR   EMBL; AB063062; BAB60784.1; -; mRNA.
DR   RefSeq; NP_001270650.1; NM_001283721.1.
DR   RefSeq; XP_005547629.1; XM_005547572.2.
DR   AlphaFoldDB; Q9N0D3; -.
DR   STRING; 9541.XP_005547625.1; -.
DR   GeneID; 101867350; -.
DR   KEGG; mcf:101867350; -.
DR   CTD; 151647; -.
DR   eggNOG; ENOG502RZN9; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0048018; F:receptor ligand activity; ISS:UniProtKB.
DR   GO; GO:0048246; P:macrophage chemotaxis; ISS:UniProtKB.
DR   GO; GO:0006909; P:phagocytosis; ISS:UniProtKB.
DR   GO; GO:0010469; P:regulation of signaling receptor activity; ISS:UniProtKB.
DR   GO; GO:0042554; P:superoxide anion generation; ISS:UniProtKB.
DR   InterPro; IPR020350; Chemokine-like_TAFA.
DR   Pfam; PF12020; TAFA; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..35
FT                   /evidence="ECO:0000255"
FT   CHAIN           36..140
FT                   /note="Chemokine-like protein TAFA-4"
FT                   /id="PRO_0000042729"
FT   CONFLICT        19
FT                   /note="V -> L (in Ref. 3; BAB60784)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   140 AA;  15640 MW;  173DA66AB6C97F03 CRC64;
     MRSPRMRACA KSVLLSHWVF LAYVLMVCCK LMSASSQHLR GHAGHHQIKQ GTCEVVAVHR
     CCNKNRIEER SQTVKCSCFP GQVAGTTRAQ PSCVEASIVI QKWWCHMNPC LEGEDCKVLP
     DYSGWSCSSG NKVKTTKVTR